Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Marvin Steijaert"'
Autor:
Herman van Wietmarschen, Yan Schroën, Victor Kallen, Marvin Steijaert, Albert A. de Graaf, Ben van Ommen, Jan van der Greef
Publikováno v:
World Journal of Traditional Chinese Medicine, Vol 3, Iss 1, Pp 38-49 (2017)
Western science has been strong in measuring details of biological systems such as gene expression levels and metabolite concentrations, and has generally followed a bottom up approach with regard to explaining biological phenomena. Chinese medicine
Externí odkaz:
https://doaj.org/article/070ce66daef34be5adadd7b51ef9b99a
Autor:
Iris Fahrenfort, Marvin Steijaert, Trijntje Sjoerdsma, Evan Vickers, Harris Ripps, Jorrit van Asselt, Duco Endeman, Jan Klooster, Robert Numan, Huub ten Eikelder, Henrique von Gersdorff, Maarten Kamermans
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e6090 (2009)
BACKGROUND:Recent studies designed to identify the mechanism by which retinal horizontal cells communicate with cones have implicated two processes. According to one account, horizontal cell hyperpolarization induces an increase in pH within the syna
Externí odkaz:
https://doaj.org/article/0d892894547642d3a65a931ee3006973
Autor:
Wolfgang De Meuter, Andrey Gedich, Marvin Steijaert, Jörg K. Wegner, Mathijs Saey, Roel Wuyts, Dries Harnie, Hugo Ceulemans, A. Vapirev
Publikováno v:
Future Generation Computer Systems. 67:409-417
In the context of drug discovery, a key problem is the identification of candidate molecules that affect proteins associated with diseases. Inside Janssen Pharmaceutica, the Chemogenomics project aims to derive new candidates from existing experiment
Autor:
Marvin Steijaert, Yan Schroën, Herman van Wietmarschen, Ben van Ommen, Albert A. de Graaf, Jan van der Greef, Victor Kallen
Publikováno v:
World Journal of Traditional Chinese Medicine, Vol 3, Iss 1, Pp 38-49 (2017)
Western science has been strong in measuring details of biological systems such as gene expression levels and metabolite concentrations, and has generally followed a bottom up approach with regard to explaining biological phenomena. Chinese medicine
Autor:
Adam Arany, Jörg K. Wegner, Jorge Vialard, Vladimir Chupakhin, Marvin Steijaert, Anne E. Carpenter, Shantanu Singh, Peter Jacobus Johannes Antonius Buijnsters, Yves Moreau, Jaak Simm, Emmanuel Gustin, Ingrid Velter, Roel Wuyts, Sepp Hochreiter, A. Vapirev, Yolanda T. Chong, Hugo Ceulemans, Günter Klambauer
In both academia and the pharmaceutical industry, large-scale assays for drug discovery are expensive and often impractical, particularly for the increasingly important physiologically relevant model systems that require primary cells, organoids, who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdc9b02e29c077539f5f8d0bd2c0b57
https://lirias.kuleuven.be/handle/123456789/628737
https://lirias.kuleuven.be/handle/123456789/628737
Autor:
Jörg K. Wegner, Marvin Steijaert, Hugo Ceulemans, Sepp Hochreiter, Djork-Arné Clevert, Thomas Unterthiner, Günter Klambauer, Andreas Mayr
Publikováno v:
Chemical Science
The to date largest comparative study of nine state-of-the-art drug target prediction methods finds that deep learning outperforms all other competitors. The results are based on a benchmark of 1300 assays and half a million compounds.
Deep lear
Deep lear
Autor:
Jorge Vialard, Vladimir Chupakhin, Yves Moreau, Günter Klambauer, Shantanu Singh, Marvin Steijaert, Adam Arany, Sepp Hochreiter, Anne E. Carpenter, Hugo Ceulemans, Roel Wuyts, Emmanuel Gustin, Jörg K. Wegner, Peter Jacobus Johannes Antonius Buijnsters, A. Vapirev, Ingrid Velter, Jaak Simm, Yolanda T. Chong
We repurpose a High-Throughput (cell) Imaging (HTI) screen of a glucocorticoid receptor assay to predict target protein activity in multiple other seemingly unrelated assays. In two ongoing drug discovery projects, our repurposing approach increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0059d469db8ccdab4e892970cfab25d3
Autor:
Duco Endeman, MN Marvin Steijaert, Trijntje Sjoerdsma, Maarten Kamermans, Iris Fahrenfort, Huub M. M. ten Eikelder
Publikováno v:
The Journal of Physiology. 590:5581-5595
In neuronal systems, excitation and inhibition must be well balanced to ensure reliable information transfer. The cone/horizontal cell (HC) interaction in the retina is an example of this. Because natural scenes encompass an enormous intensity range
Autor:
MN Marvin Steijaert, Peter A. J. Hilbers, Dragan Bošnački, ten Hmm Huub Eikelder, Aml Anthony Liekens
Publikováno v:
Mathematical Biosciences, 227(2), 105-116. Elsevier
Mathematical biosciences
Mathematical biosciences
Biochemical reaction networks are often described by deterministic models based on macroscopic rate equations. However, for small numbers of molecules, intrinsic noise can play a significant role and stochastic methods may thus be required. In this w
Autor:
Peter A. J. Hilbers, van den Jhk Jeroen Brink, MN Marvin Steijaert, ten Hmm Huub Eikelder, Aml Anthony Liekens
Publikováno v:
Journal of computational biology
Journal of Computational Biology, 17(2), 189-199. Mary Ann Liebert Inc.
Journal of Computational Biology, 17(2), 189-199. Mary Ann Liebert Inc.
accepted by J. Comput. Biology 07/24/2009Cells of all organisms share the ability to respond to various extracellular signals. Depending on the cell type and the organism, these signals may include hormones secreted by other cells or changes in nutri