Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Marvin R. Boots"'
Autor:
Sharon G. Boots, Marvin R. Boots
Publikováno v:
Journal of Pharmaceutical Sciences. 64:1949-1952
A series of 4-dialkylamino-3-hydroxybutyric acid hydrochlorides and methochlorides, analogs of carnitine, was synthesized by treatment of tert-butyl 3,4-epoxybutyrate with the appropriate amine or amine hydrochloride in methanol followed by mild acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47773fc32a2448a6ecb47afcac98772
https://doi.org/10.1002/jps.2600641208
https://doi.org/10.1002/jps.2600641208
Publikováno v:
Journal of Pharmaceutical Sciences. 65:724-727
Two series of half acid esters of succinic and glutaric acids were synthesized and assayed for inhibition of rat liver β‐hydroxy‐β‐methylglutaryl coenzyme A reductase. Irreversible inhibition was studied by incorporation of a potential alkyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f671d8013a3b873a427d6c528a07072d
https://doi.org/10.1002/jps.2600650523
https://doi.org/10.1002/jps.2600650523
Publikováno v:
Journal of Pharmaceutical Sciences. 65:548-552
A series of half acid esters of 1‐(4‐biphenylyl)pentanol was synthesized and assayed for inhibition of rat liver β‐hydroxy‐β‐methylglutaryl coenzyme A reductase. The number of methylenes separating the carboxyl and ester groups was varied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92eb5294cdfe437beadb18c13e416652
https://doi.org/10.1002/jps.2600650417
https://doi.org/10.1002/jps.2600650417
Autor:
Marvin R. Boots, Scherer S. Duke
Publikováno v:
Journal of Medicinal Chemistry. 26:1556-1561
In 1962, Owen, Dietz, and Camiener reported the isolation of a new antitumor antibiotic from the culture filtrate of Streptomyces sparsogenes. The structure of the crystalline antibiotic, named sparsomycin, remained elusive until 1970, when Wiley and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861287156bcb3c00e0b4503ca567aa43
https://doi.org/10.1021/jm00365a003
https://doi.org/10.1021/jm00365a003
Publikováno v:
Journal of Pharmaceutical Sciences. 62:952-957
A series of arylalkyl hydrogen succinates and glutarates was synthesized and assayed for inhibition of yeast β -hydroxy- β - methylglutaryl coenzyme A reductase. The following compounds were found to be particularly active as inhibitors: l-(4-biphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca93c26041e8c07f6daa14aa512ba70
https://doi.org/10.1002/jps.2600620620
https://doi.org/10.1002/jps.2600620620
Autor:
Sharon G. Boots, Marvin R. Boots
Publikováno v:
Journal of Pharmaceutical Sciences. 64:1262-1264
A four-step synthesis of (RS)-carnitine chloride was developed using extremely mild reaction conditions and versatile intermediates. Crotyl chloride was converted to tert-butyl 3-butenoate using tert-butyl alcohol and triethylamine in ether. Treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432f61342e47ac4e9301aa5c338802d3
https://doi.org/10.1002/jps.2600640737
https://doi.org/10.1002/jps.2600640737
Publikováno v:
Journal of Pharmaceutical Sciences. 69:202-204
Carnitine analogs with various substituents on the nitrogen were tested for their effect on carnitine acetyltransferase from rat sperm and pigeon breast. A radiometric assay was used to measure the formation of acetylcarnitine in the presence of othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1da4be75216a236d7d5132beeda4efe
https://doi.org/10.1002/jps.2600690223
https://doi.org/10.1002/jps.2600690223
Autor:
Brenda L. Dunlavey, Marie A. Franklin, Kenneth S. Rogers, Janice Costello, Cynthia Lipsitz, Marvin R. Boots, Sharon G. Boots
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 151(2)
SummaryIsophthalic acid, 5-carboxy-, 5-hydroxy-, 5-methoxy-, 5-fluoro-, 5-bromo-, 5-cyano-, and 5-methylisophthalic acid were inhibitors competitive with l-glutamate for bovine liver glutamate dehydrogenase. The extent of inhibition by the derived co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9758ec5c4f8122e58a6fdc1cce53be36
https://pubmed.ncbi.nlm.nih.gov/2935
https://pubmed.ncbi.nlm.nih.gov/2935
Autor:
Sharon G. Boots, Marvin R. Boots
Publikováno v:
Chemischer Informationsdienst. 7
A series of 4-dialkylamino-3-hydroxybutyric acid hydrochlorides and methochlorides, analogs of carnitine, was synthesized by treatment of tert-butyl 3,4-epoxybutyrate with the appropriate amine or amine hydrochloride in methanol followed by mild acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2707bc89faeb9f44c9f2f88bde784219
https://doi.org/10.1002/chin.197614127
https://doi.org/10.1002/chin.197614127
Publikováno v:
Chemischer Informationsdienst. 14
In an effort to increase the specificity of the potent phosphodiesterase inhibitor papaverine, we synthesized two series of novel 1-(4-aminobenzyl)- and 1-(4-aminophenyl)isoquinoline derivatives, incorporating alkylating moieties on the amine substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149bd6b9a87d8520eda7c53e06b6ee12
https://doi.org/10.1002/chin.198328227
https://doi.org/10.1002/chin.198328227