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Autor:
Julia M. Reber, Jovana Božić-Petković, Michelle Lippmann, Marvin Mazzardo, Asisa Dilger, Rebecca Warmers, Alexander Bürkle, Aswin Mangerich
Publikováno v:
Cell biology and toxicologyReferences.
AbstractPARP1 (aka ARTD1) acts as a prime sensor of cellular genotoxic stress response. PARP1 detects DNA strand breaks and subsequently catalyzes the formation of poly(ADP-ribose) (PAR), which leads to the recruitment of the scaffold protein XRCC1 d