Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Marvin M van Luijn"'
Autor:
Marvin M van Luijn, Arjan A van de Loosdrecht, Margit H Lampen, Peter A van Veelen, Adri Zevenbergen, Michel G D Kester, Arnoud H de Ru, Gert J Ossenkoppele, Thorbald van Hall, S Marieke van Ham
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34649 (2012)
Antigen presentation by HLA class I (HLA-I) and HLA class II (HLA-II) complexes is achieved by proteins that are specific for their respective processing pathway. The invariant chain (Ii)-derived peptide CLIP is required for HLA-II-mediated antigen p
Externí odkaz:
https://doaj.org/article/c4a5eb86be014846968ef1aa4463edb1
Autor:
Laurens Bogers, Hendrik J. Engelenburg, Malou Janssen, Peter-Paul A. Unger, Marie-José Melief, Annet F. Wierenga-Wolf, Cheng-Chih Hsiao, Matthew R.J. Mason, Jörg Hamann, Jamie van Langelaar, Joost Smolders, Marvin M. van Luijn
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104465- (2023)
Summary: Background: Although distinct brain-homing B cells have been identified in multiple sclerosis (MS), it is unknown how these further evolve to contribute to local pathology. We explored B-cell maturation in the central nervous system (CNS) of
Externí odkaz:
https://doaj.org/article/ab5257161bc347f88c384c428b46a61f
Autor:
Liza Rijvers, Jamie van Langelaar, Laurens Bogers, Marie-José Melief, Steven C. Koetzier, Katelijn M. Blok, Annet F. Wierenga-Wolf, Helga E. de Vries, Jasper Rip, Odilia B.J. Corneth, Rudi W. Hendriks, Roland Grenningloh, Ursula Boschert, Joost Smolders, Marvin M. van Luijn
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Recent clinical trials have shown promising results for the next-generation Bruton’s tyrosine kinase (BTK) inhibitor evobrutinib in the treatment of multiple sclerosis (MS). BTK has a central role in signaling pathways that govern the development o
Externí odkaz:
https://doaj.org/article/0ecd2fa4ff9540149043120647a04a27
Autor:
Steven C. Koetzier, Jamie van Langelaar, Annet F. Wierenga-Wolf, Marie-José Melief, Kim Pol, Suzanne Musters, Erik Lubberts, Willem A. Dik, Joost Smolders, Marvin M. van Luijn
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In early multiple sclerosis (MS), an IFN-γhighGM-CSFhighIL-17low CD4+ T-cell subset termed T helper 17.1 (Th17.1) reveals enhanced capacity to infiltrate the central nervous system. Th17.1 cells express high levels of multidrug resistance protein 1
Externí odkaz:
https://doaj.org/article/28c97a48d5f44f019256739f1b535070
Publikováno v:
Seminars in immunopathology, 44, 855-867. Springer Verlag GmbH
Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to
Autor:
Arjan A. van de Loosdrecht, S. Marieke van Ham, Gert J. Ossenkoppele, Theresia M. Westers, Adri Zevenbergen, Martine E.D. Chamuleau, Willemijn van den Ancker, Marvin M. van Luijn
Supplementary Figure 1 from Absence of Class II–Associated Invariant Chain Peptide on Leukemic Blasts of Patients Promotes Activation of Autologous Leukemia-Reactive CD4+ T Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5070ca928b1d1b1945b9bb42ae9f2a90
https://doi.org/10.1158/0008-5472.22390910.v1
https://doi.org/10.1158/0008-5472.22390910.v1
Autor:
Arjan A. van de Loosdrecht, S. Marieke van Ham, Gert J. Ossenkoppele, Theresia M. Westers, Adri Zevenbergen, Martine E.D. Chamuleau, Willemijn van den Ancker, Marvin M. van Luijn
Immune escape in cancer poses a substantial obstacle to successful cancer immunotherapy. Multiple defects in HLA class I antigen presentation exist in cancer that may contribute to immune escape, but less is known about roles for HLA class II antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd7275abb8c2f0f40d63049f78775b95
https://doi.org/10.1158/0008-5472.c.6503099.v1
https://doi.org/10.1158/0008-5472.c.6503099.v1
Autor:
Steven C. Koetzier, Jamie van Langelaar, Marie-José Melief, Annet F. Wierenga-Wolf, Cato E. A. Corsten, Katelijn M. Blok, Cindy Hoeks, Bieke Broux, Beatrijs Wokke, Marvin M. van Luijn, Joost Smolders
Publikováno v:
Cells, 11(10):1634. Multidisciplinary Digital Publishing Institute (MDPI)
Cells; Volume 11; Issue 10; Pages: 1634
Cells; Volume 11; Issue 10; Pages: 1634
The effector programs of CD8(+) memory T cells are influenced by the transcription factors RUNX3, EOMES and T-bet. How these factors define brain-homing CD8(+) memory T cells in multiple sclerosis (MS) remains unknown. To address this, we analyzed bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629770296e66705d4935ad5be255e540
https://pure.eur.nl/en/publications/91fe3048-a277-4d6c-9a9f-6832831d77c3
https://pure.eur.nl/en/publications/91fe3048-a277-4d6c-9a9f-6832831d77c3
Autor:
Jamie van Langelaar, J P A Samijn, Joost Smolders, Pieter A. van Doorn, Marvin M van Luijn, Theodora A Siepman, Menno C. van Zelm, Annet F Wierenga-Wolf, Caroline J.M. Luijks, Andrew I. Bell
Publikováno v:
European Journal of Immunology, 51, 626-633. Wiley-VCH Verlag
European Journal of Immunology, 51(3), 626-633. Wiley-VCH
European Journal of Immunology, 51(3), 626-633. Wiley-VCH
Epstein-Barr virus (EBV) infection of B cells is associated with increased multiple sclerosis (MS) susceptibility. Recently, we found that CXCR3-expressing B cells preferentially infiltrate the central nervous system of MS patients. In chronic virus-
Autor:
Tonya White, Rinze F. Neuteboom, Joost Smolders, Karim L. Kreft, Menno C. van Zelm, Marvin M. van Luijn, Casper L. de Mol, Philip R. Jansen, Kirsten I.M. Looman, Henriette A. Moll
Publikováno v:
European Journal of Neurology, 28(11), 3731-3741. Wiley-Blackwell
European Journal of Neurology, 28(11), 3731-3741. Wiley-Blackwell Publishing Ltd
European Journal of Neurology
de Mol, C L, Looman, K I M, van Luijn, M M, Kreft, K L, Jansen, P R, van Zelm, M C, Smolders, J J F M, White, T J H, Moll, H A & Neuteboom, R F 2021, ' T cell composition and polygenic multiple sclerosis risk : A population-based study in children ', European Journal of Neurology, vol. 28, no. 11, pp. 3731-3741 . https://doi.org/10.1111/ene.15019
European Journal of Neurology, 28(11), 3731-3741. Wiley-Blackwell Publishing Ltd
European Journal of Neurology
de Mol, C L, Looman, K I M, van Luijn, M M, Kreft, K L, Jansen, P R, van Zelm, M C, Smolders, J J F M, White, T J H, Moll, H A & Neuteboom, R F 2021, ' T cell composition and polygenic multiple sclerosis risk : A population-based study in children ', European Journal of Neurology, vol. 28, no. 11, pp. 3731-3741 . https://doi.org/10.1111/ene.15019
Background and purpose Patients with multiple sclerosis (MS) have altered T cell function and composition. Common genetic risk variants for MS affect proteins that function in the immune system. It is currently unclear to what extent T cell compositi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a291290ee54e55706a67f4a7dddd93f4
https://research.vu.nl/en/publications/2acc3ab1-0684-48ee-9251-c11ecb6b824c
https://research.vu.nl/en/publications/2acc3ab1-0684-48ee-9251-c11ecb6b824c