Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Marvin L Meistrich"'
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242218 (2020)
Improvements in survival rates with gonad-sparing protocols for childhood and adolescence cancer have increased the optimism of survivors to become parents after treatment. Findings in rodents indicate that chromosomal aberrations can be induced in m
Externí odkaz:
https://doaj.org/article/cc5708a860284f2c880c6976d7ac63af
Autor:
Paul B Comish, Ana Luiza Drumond, Hazel L Kinnell, Richard A Anderson, Angabin Matin, Marvin L Meistrich, Gunapala Shetty
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93311 (2014)
Exposure to radiation during fetal development induces testicular germ cell tumors (TGCT) and reduces spermatogenesis in mice. However, whether DNA damaging chemotherapeutic agents elicit these effects in mice remains unclear. Among such agents, cycl
Externí odkaz:
https://doaj.org/article/46f27dca5a4e46849f8299f3377c0081
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32064 (2012)
The prevalence of testicular germ cell tumors (TGCT), a common solid tissue malignancy in young men, has been annually increasing at an alarming rate of 3%. Since the majority of testicular cancers are derived from germ cells at the stage of transfor
Externí odkaz:
https://doaj.org/article/40a79151ed0c4f90b30583e0ab64c232
Autor:
Yong-Hyun Shin, Youngsok Choi, Serpil Uckac Erdin, Svetlana A Yatsenko, Malgorzata Kloc, Fang Yang, P Jeremy Wang, Marvin L Meistrich, Aleksandar Rajkovic
Publikováno v:
PLoS Genetics, Vol 6, Iss 11, p e1001190 (2010)
Meiosis is unique to germ cells and essential for reproduction. During the first meiotic division, homologous chromosomes pair, recombine, and form chiasmata. The homologues connect via axial elements and numerous transverse filaments to form the syn
Externí odkaz:
https://doaj.org/article/0f1fd978d35047ef9f0fd6d58f9236bf
Autor:
Jennifer M. Mitchell, Gunapala Shetty, Marvin L. Meistrich, Thien Trong Phan, Ramesh C. Tailor, Carol B. Hanna, Kyle E. Orwig, Truong Nguyen Anh Lam, Jie Zhang, Karen A. Peters, Amander T. Clark, Maria Cecilia T. Penedo
Publikováno v:
Andrology
Andrology, vol 9, iss 5
Andrology, vol 9, iss 5
BackgroundCancer treatment of prepubertal patients impacts future fertility due to the abolition of spermatogonial stem cells (SSCs). In macaques, spermatogenesis could be regenerated by intratesticular transplantation of SSCs, but no studies have in
Autor:
C A Rezende-Melo, Martin M. Matzuk, G M Buchold, Marvin L. Meistrich, Shosei Yoshida, Hélio Chiarini-Garcia, Gunapala Shetty, Kenshiro Hara, F. R. C. L. Almeida, A L Drumond-Bock, Andre L. Caldeira-Brant
Publikováno v:
Reproduction. 160:205-215
The existence of cytoplasmic passages between germ cells and their potential function in the control of the spermatogenic process has long been an intriguing question. Evidence of the important role of such structures, known as intercellular bridges
Autor:
Thien Trong Phan, Kyle E. Orwig, Carol B. Hanna, Ramesh C. Tailor, Jie Zhang, Karen A. Peters, Jennifer M. Mitchell, Gunapala Shetty, Marvin L. Meistrich, Zhuang Wu, Jennifer M. Meyer, Truong Nguyen Anh Lam, Lorraine R Hill, Maria Cecilia T. Penedo
Publikováno v:
Andrology
Background In male pre-pubertal cancer patients, radiation and chemotherapy impact future fertility by eradication of spermatogonial stem cells (SSCs). In macaques, spermatogenesis could be regenerated by intratesticular transplantation of SSCs, but
Autor:
Reham Waheeb, Marvin L. Meistrich, Thomas X. Garcia, Gunapala Shetty, Marie Claude Hofmann, Pooja Gandhi, Parag Parekh, Vivek Jain
Publikováno v:
The FASEB Journal. 33:8423-8435
Cytochrome P450 family 26 subfamily B member 1 (CYP26B1) regulates the concentration of all-trans retinoic acid (RA) and plays a key role in germ cell differentiation by controlling local distribution of RA. The mechanisms regulating Cyp26b1 expressi
Autor:
Gunapala Shetty, Victoria H. J. Roberts, Marvin L. Meistrich, Hanna Valli-Pulaski, Adetunji P. Fayomi, Cathy Ramsey, Carol B. Hanna, Jon D. Hennebold, Ina Dobrinski, Nicola Robertson, Meena Sukhwani, Karen A. Peters, Kyle E. Orwig, Lisa A Houser
Publikováno v:
Science. 363:1314-1319
Preserving male fertility Before chemotherapy or radiation treatment, sperm from adult men can be cryopreserved for future use. However, this is not possible for prepubertal boys. Fayomi et al. grafted cryopreserved testicular tissue from castrated p
Autor:
Thien Trong Phan, Marvin L. Meistrich, Truong Nguyen Anh Lam, Zhuang Wu, Gunapala Shetty, Kyle E. Orwig
Publikováno v:
Andrology. 7:257-265
Background Cytotoxic cancer treatments, such as irradiation, can cause permanent sterility in male mammals owing to the loss of spermatogonial stem cells. In animal models, spermatogenesis could be restored from transplanted spermatogonial stem cells