Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Marvin K, Schulte"'
Autor:
Malaika D. Argade, Laura DeCristofano, Nirajan Bhattarai, Marvin K. Schulte, Malgorzata Dukat
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100286- (2022)
Galantamine (1), one of only five agents currently approved for the treatment of Alzheimer’s disease, is thought to act primarily as an inhibitor of acetylcholinesterase (AChE) and possibly as a positive allosteric modulator (PAM) of neuronal α7 n
Externí odkaz:
https://doaj.org/article/a8a0f918e2744feeb7aa9fd23db0b4f7
Autor:
Kavita Sharma, Samjhana Pradhan, Lawrence K. Duffy, Sabina Yeasmin, Nirajan Bhattarai, Marvin K. Schulte
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12987 (2021)
Despite the identification of Aβ plaques and NFTs as biomarkers for Alzheimer’s disease (AD) pathology, therapeutic interventions remain elusive, with neither an absolute prophylactic nor a curative medication available to impede the progression o
Externí odkaz:
https://doaj.org/article/d73a766c1ba54aee93f0a727a2ff4982
Publikováno v:
Alcohol. 93:35-44
Background Binge drinking can increase an individual's risk of developing alcohol use disorder (AUD). Ethanol targets multiple neurotransmitter systems; however, not much is known about its effects on the cholinergic system. Nicotinic acetylcholine r
Autor:
Osama I. Alwassil, Marvin K. Schulte, Sanjay S Aripaka, Malgorzata Dukat, Jens D. Mikkelsen, Shailesh Khatri
Publikováno v:
ACS Chemical Neuroscience. 12:2194-2201
We previously reported that N-(3-chlorophenyl)guanidine (1) represents a novel α7 nicotinic ACh (nACh) receptor antagonist chemotype. In the present study, a small series of compounds was synthesized with the intent to investigate the structure-acti
Autor:
Osama I, Alwassil, Shailesh, Khatri, Marvin K, Schulte, Sanjay S, Aripaka, Jens D, Mikkelsen, Małgorzata, Dukat
Publikováno v:
ACS chemical neuroscience. 12(12)
We previously reported that
Publikováno v:
Alcohol (Fayetteville, N.Y.). 93
Binge drinking can increase an individual's risk of developing alcohol use disorder (AUD). Ethanol targets multiple neurotransmitter systems; however, not much is known about its effects on the cholinergic system. Nicotinic acetylcholine receptors (n
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4918, p 4918 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 4918, p 4918 (2020)
Inflammation is a key physiological phenomenon that can be pervasive when dysregulated. Persistent chronic inflammation precedes several pathophysiological conditions forming one of the critical cellular homeostatic checkpoints. With a steady global
Autor:
Michael M. White, Osama I. Alwassil, Marvin K. Schulte, Shailesh Khatri, Ahmed S. Abdelkhalek, Heather L. Nyce, Genevieve S Alley, Malgorzata Dukat, Philip D. Mosier
Publikováno v:
ACS Chemical Neuroscience. 10:1380-1389
Arylguanidines, depending upon their aromatic substitution pattern, display varying actions at 5-HT3 receptors (e.g., partial agonist, agonist, superagonist). Here, we demonstrate that conformational constraint of these agents as dihydroquinazolines
Autor:
Shailesh Khatri, Shane Alexander Rideout, Marvin K. Schulte, Michael E. Harris, Clare Stokes, Roger L. Papke, Karsten Hueffer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports
Scientific Reports
Rabies virus induces drastic behaviour modifications in infected hosts. The mechanisms used to achieve these changes in the host are not known. The main finding of this study is that a region in the rabies virus glycoprotein, with homologies to snake
Publikováno v:
Eur J Pain
BackgroundNeuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels. The 42 subtype of nAChRs plays an important role in the mediation of pain and several nicotine-evoked responses. Agonists and partial agonists of 42 nAChRs s