Zobrazeno 1 - 10
of 459
pro vyhledávání: '"Marvin J. Miller"'
Autor:
Masahide Yano, Jessica M. Lawson-Rulli, Reilly M. Coates, Jennifer Heldring, Marvin J. Miller, Rui Liu
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 11, Iss , Pp 100147- (2024)
Globally, millions of infections that are resistant to antimicrobial agents are reported annually, leading to more than 700,000 fatalities. Among all, challenges arise particularly from nontuberculosis mycobacterial (NTM) and Gram-negative bacteria,
Externí odkaz:
https://doaj.org/article/27c206d758504749980add0a33306990
Autor:
Priya Ragunathan, Pearly Shuyi Ng, Samsher Singh, Wee Han Poh, Dennis Litty, Nitin Pal Kalia, Simon Larsson, Amaravadhi Harikishore, Scott A. Rice, Philip W. Ingham, Volker Müller, Garrett Moraski, Marvin J. Miller, Thomas Dick, Kevin Pethe, Gerhard Grüber
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT The Mycobacterium tuberculosis (Mtb) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and discov
Externí odkaz:
https://doaj.org/article/326a564021ea4d0fb1574e9e794a038f
Autor:
Nicole Scherr, Raphael Bieri, Sangeeta S. Thomas, Aurélie Chauffour, Nitin Pal Kalia, Paul Schneide, Marie-Thérèse Ruf, Araceli Lamelas, Malathy S. S. Manimekalai, Gerhard Grüber, Norihisa Ishii, Koichi Suzuki, Marcel Tanner, Garrett C. Moraski, Marvin J. Miller, Matthias Witschel, Vincent Jarlier, Gerd Pluschke, Kevin Pethe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU). Existing anti-tubercular drugs have been used to treat the condition with varying success. Here, the authors show that a clinical-stage drug candidate for tuberculosis, Q203, is effe
Externí odkaz:
https://doaj.org/article/ead11814b4ee465d85398bdcb2064c81
Autor:
Sarah M. Hopfner, Bei Shi Lee, Nitin P. Kalia, Marvin J. Miller, Kevin Pethe, Garrett C. Moraski
Publikováno v:
Applied Sciences, Vol 11, Iss 19, p 9092 (2021)
The development of cytochrome bd oxidase (cyt-bd) inhibitors are needed for comprehensive termination of energy production in Mycobacterium tuberculosis (Mtb) to treat tuberculosis infections. Herein, we report on the structure-activity-relationships
Externí odkaz:
https://doaj.org/article/d8b5a4fb69374ba5bcd768dff5a267ab
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1949-1980 (2016)
The hetero-Diels–Alder reaction between a nitroso dienophile and a conjugated diene to give the 3,6-dihydro-2H-1,2-oxazine scaffold is useful for the synthesis of many biologically interesting molecules due to the diverse opportunities created by s
Externí odkaz:
https://doaj.org/article/659132afd5d84690b0013c022d101ea2
Autor:
Fabrice Betoudji, Taha Abd El Rahman, Marvin J. Miller, Manuka Ghosh, Mario Jacques, Kamal Bouarab, François Malouin
Publikováno v:
Pathogens, Vol 9, Iss 10, p 806 (2020)
Siderophores produced in soil by plant growth-promoting rhizobacteria (PGPRs) play several roles, including nutrient mobilizers and can be useful as plants defense elicitors. We investigated the role of a synthetic mixed ligand bis-catechol-mono-hydr
Externí odkaz:
https://doaj.org/article/12b686de5948489c8adbaea0dc83b0fd
Publikováno v:
BioMetals. 36:315-320
Despite advances in chemotherapeutic interventions for the treatment of malaria, there is a continuing need for the development of new antimalarial agents. Previous studies indicated that co-administration of chloroquine with antioxidants such as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580509361f9be85d1b7dc9074cdb2c0d
https://doi.org/10.1007/s10534-022-00375-8
https://doi.org/10.1007/s10534-022-00375-8
Autor:
Rui Liu, Marvin J. Miller
Publikováno v:
Acc Chem Res
This Account describes fundamental chemistry that promoted the discovery of new antibiotics. Specifically, the NH acidity of simple hydroxamic acid derivatives facilitated the syntheses of novel β-lactams (oxamazins and monobactams), siderophore mim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b005db9daf0a2883fc39e4ce602977
https://doi.org/10.1021/acs.accounts.1c00004
https://doi.org/10.1021/acs.accounts.1c00004
Autor:
Kevin Pethe, Karin Savková, Lowell D. Markley, Marvin J. Miller, Rui Ma, Gauri Shetye, Garrett C. Moraski, Bei Shi Lee, Katarína Mikušová, Patricia A. Miller, Rui Liu, Scott G. Franzblau
Publikováno v:
RSC Med Chem
The formation efficiency of hydride-induced Meisenheimer complexes of nitroaromatic compounds is consistent with their anti-TB activities exemplied by MDL860 and benzothiazol N-oxide (BTO) analogs. Herein we report that nitro cyano phenoxybenzenes (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddeb87aa52273df4ebcad094be1d39e
https://doi.org/10.1039/d0md00390e
https://doi.org/10.1039/d0md00390e
Publikováno v:
The Journal of Antibiotics. 73:152-157
Antibiotics that are normally used to treat infections caused by Gram-positive bacteria might be made effective against Gram-negative bacterial infections, if they can circumvent permeability barriers and antibiotic deactivation processes associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453182600ca1e5b6965cd169fd548e0b
https://doi.org/10.1038/s41429-019-0268-7
https://doi.org/10.1038/s41429-019-0268-7