Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marvin H. Gee"'
Autor:
Juan L Mendoza, Suzanne Fischer, Marvin H Gee, Lilian H Lam, Simon Brackenridge, Fiona M Powrie, Michael Birnbaum, Andrew J McMichael, K Christopher Garcia, Geraldine M Gillespie
Publikováno v:
eLife, Vol 9 (2020)
T cell cross-reactivity ensures that diverse pathogen-derived epitopes encountered during a lifetime are recognized by the available TCR repertoire. A feature of cross-reactivity where previous exposure to one microbe can alter immunity to subsequent
Externí odkaz:
https://doaj.org/article/dbdcd296f0af449096cad58507ea9f5c
Autor:
Xiang Zhao, Elizabeth M. Kolawole, Waipan Chan, Yinnian Feng, Xinbo Yang, Marvin H. Gee, Kevin M. Jude, Leah V. Sibener, Polly M. Fordyce, Ronald N. Germain, Brian D. Evavold, K. Christopher Garcia
Publikováno v:
Science
Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their target ligands, peptide–major histocompatibility complexes (pMHCs). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d860002b6ad3e1c00b202f85ceddfbfb
https://doi.org/10.1126/science.abl5282
https://doi.org/10.1126/science.abl5282
Autor:
Michael T Bethune, Marvin H Gee, Mario Bunse, Mark S Lee, Eric H Gschweng, Meghana S Pagadala, Jing Zhou, Donghui Cheng, James R Heath, Donald B Kohn, Michael S Kuhns, Wolfgang Uckert, David Baltimore
Publikováno v:
eLife, Vol 5 (2016)
T cells engineered to express a tumor-specific αβ T cell receptor (TCR) mediate anti-tumor immunity. However, mispairing of the therapeutic αβ chains with endogenous αβ chains reduces therapeutic TCR surface expression and generates self-reacti
Externí odkaz:
https://doaj.org/article/6a88487d0cf04964bf9e93ce1693a670
Publikováno v:
Trends in Cancer. 6:299-318
The ideal cancer target antigen (Ag) is expressed at high copy numbers on neoplastic cells, absent on normal tissues, and contributes to the survival of cancer cells. Despite significant investments in the identification of cell surface Ags, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b71fa16b35b20becf46e52bdd914c5
https://doi.org/10.1016/j.trecan.2020.01.002
https://doi.org/10.1016/j.trecan.2020.01.002
Autor:
John D. Leonard, Alejandro Ramirez, Jason Romero, Jake Kleiner, Joanna Dreux, Bindu Hegde, Bryan Xie, Akshay Sharathchandra, Nathan Katz, Venita I. DeAlmeida, Hans-Peter Gerber, Marvin H. Gee, Leah V. Sibener
Publikováno v:
Cancer Research. 82:578-578
Peptide-HLA (pHLA)- targeting therapeutics, such as T cell receptor-engineered T cells (TCR-T), have had clinical success in treating solid tumors. However, challenges related to safety exist: major concerns remain surrounding the cross-reactivity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b73cf224f999d7de80b7d553614fc9
https://doi.org/10.1158/1538-7445.am2022-578
https://doi.org/10.1158/1538-7445.am2022-578
Autor:
Suzanne Fischer, Simon Brackenridge, Andrew J. McMichael, Lilian H. Lam, Michael E. Birnbaum, Juan L. Mendoza, K. Christopher Garcia, Fiona Powrie, Geraldine M. Gillespie, Marvin H. Gee
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
T cell cross-reactivity ensures that diverse pathogen-derived epitopes encountered during a lifetime are recognized by the available TCR repertoire. A feature of cross-reactivity where previous exposure to one microbe can alter immunity to subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5c5911921708bb083303fa053a2091
https://pubmed.ncbi.nlm.nih.gov/32716298
https://pubmed.ncbi.nlm.nih.gov/32716298
Autor:
Marvin H. Gee, Timothy P. Riley, Brian M. Baker, Kendra C. Foley, K. Christopher Garcia, Craig W. Vander Kooi, Lance M. Hellman, Juan L. Mendoza, Jesus A. Alonso, Michael I. Nishimura
Publikováno v:
Nature chemical biology
T cell receptor cross-reactivity allows a fixed T cell repertoire to respond to a much larger universe of potential antigens. Recent work has emphasized the importance of peptide structural and chemical homology, as opposed to sequence similarity, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79c97dc8a1063f3fe2446d5e2a7e1d5
https://doi.org/10.1038/s41589-018-0130-4
https://doi.org/10.1038/s41589-018-0130-4
The big data revolution has transformed the landscape of immunology research. As inaugural students of Stanford's new Computational and Systems Immunology PhD track, we share our experiences and advice with other institutions considering a similar pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ae99b4c462e1a63487d6d50ee681ae
https://europepmc.org/articles/PMC7035103/
https://europepmc.org/articles/PMC7035103/
Publikováno v:
Biochemical pharmacology. 168
High-potency oncology compounds such as antibody- drug conjugates, T cell redirecting, and CAR-T cell therapies have provided transformational responses in patients with liquid tumors. However, they delivered only limited benefit to solid tumor patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fc20b38b41c05780fff116390cb99f
https://pubmed.ncbi.nlm.nih.gov/31323186
https://pubmed.ncbi.nlm.nih.gov/31323186
T cell receptors (TCRs) exhibit varying degrees of cross-reactivity for peptides presented by the human leukocyte antigen (HLA). In engineered T cell therapies, TCR affinity maturation is a strategy to improve the sensitivity and potency to often a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b65703c6cd57979ae6e027b993088583