Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Marvin H. Caruthers"'
Autor:
Amy E. Campbell, Michael C. Dyle, Roberto Albanese, Tyler Matheny, Kavitha Sudheendran, Michael A. Cortázar, Thomas Forman, Rui Fu, Austin E. Gillen, Marvin H. Caruthers, Stephen N. Floor, Lorenzo Calviello, Sujatha Jagannathan
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112642- (2023)
Summary: Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, whether loss of NMD results in widespread production of truncated pro
Externí odkaz:
https://doaj.org/article/df0dd2523a6149e2baba95596b1500ad
Autor:
Sibasish Paul, Marvin H. Caruthers
Publikováno v:
Molecules, Vol 28, Iss 14, p 5380 (2023)
Phosphorodiamidate morpholinos (PMOs) are known as premier gene knockdown tools in developmental biology. PMOs are usually 25 nucleo-base-long morpholino subunits with a neutral phosphorodiamidate linkage. PMOs work via a steric blocking mechanism an
Externí odkaz:
https://doaj.org/article/f7e890abb3df4a1f91a46fcb954fff86
Autor:
Gabrijela Dumbović, Ulrich Braunschweig, Heera K. Langner, Michael Smallegan, Josep Biayna, Evan P. Hass, Katarzyna Jastrzebska, Benjamin Blencowe, Thomas R. Cech, Marvin H. Caruthers, John L. Rinn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RNA localization plays an important role in transcriptome regulation. The majority of TERT transcripts are detected in the nucleus and TUG1 lncRNAs in both the nucleus and cytoplasm. Here, the authors combine single-cell RNA imaging, antisense oligon
Externí odkaz:
https://doaj.org/article/0a69eec1edfb49478cd0ef2274c07334
Autor:
Gabrijela Dumbović, Ulrich Braunschweig, Heera K. Langner, Michael Smallegan, Josep Biayna, Evan P. Hass, Katarzyna Jastrzebska, Benjamin Blencowe, Thomas R. Cech, Marvin H. Caruthers, John L. Rinn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/f1914cc10d7442a8ae60fc72d2d25477
Autor:
Marvin H. Caruthers
Publikováno v:
CHIMIA, Vol 59, Iss 1-2 (2005)
The development of new methods for the synthesis of DNA, RNA, and phosphonates has enabled new applications in biochemistry and biology.
Externí odkaz:
https://doaj.org/article/ee96919f09fb42e588b0b2a5141a698e
Autor:
Bao T. Le, Sibasish Paul, Katarzyna Jastrzebska, Heera Langer, Marvin H. Caruthers, Rakesh N. Veedu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(36)
Recent advances in drug development have seen numerous successful clinical translations using synthetic antisense oligonucleotides (ASOs). However, major obstacles, such as challenging large-scale production, toxicity, localization of oligonucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b56fc4d244ce7b6ab11611e318beca4
https://pubmed.ncbi.nlm.nih.gov/36037350
https://pubmed.ncbi.nlm.nih.gov/36037350
Publikováno v:
Journal of the American Chemical Society. 142:16240-16253
This Article outlines the optimized chemical synthesis and preliminary biochemical characterization of a new oligonucleotide analogue called thiophosphoramidate morpholinos (TMOs). Their rational design hinges upon integrating two well-studied pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce90a19003ff244647641fce6baac89
https://doi.org/10.1021/jacs.0c04335
https://doi.org/10.1021/jacs.0c04335
Autor:
Amy E. Campbell, Michael C. Dyle, Lorenzo Calviello, Tyler Matheny, Kavitha Sudheendran, Michael A. Cortazar, Thomas Forman, Rui Fu, Austin E. Gillen, Marvin H. Caruthers, Stephen N. Floor, Sujatha Jagannathan
Nonsense-mediated RNA decay (NMD) is a surveillance mechanism that degrades both canonical and aberrant transcripts carrying premature translation termination codons. NMD is thought to have evolved to prevent the synthesis of toxic truncated proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47d1e35295b3d46515ea341d82d00715
https://doi.org/10.1101/2021.06.28.450189
https://doi.org/10.1101/2021.06.28.450189
Autor:
John L. Rinn, Evan P. Hass, Marvin H. Caruthers, Katarzyna Jastrzebska, Josep Biayna, Ulrich Braunschweig, Heera K. Langner, Gabrijela Dumbovic, Benjamin J. Blencowe, Michael J. Smallegan, Thomas R. Cech
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The spatial partitioning of the transcriptome in the cell is an important form of gene-expression regulation. Here, we address how intron retention influences the spatio-temporal dynamics of transcripts from two clinically relevant genes: TERT (Telom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5077cf0354d59af55e2f2076738a02
http://europepmc.org/articles/PMC8175569
http://europepmc.org/articles/PMC8175569
Autor:
Pawan Kumar, Marvin H. Caruthers
Publikováno v:
Accounts of chemical research. 53(10)
Chemically modified oligonucleotides are being developed as a new class of medicines for curing conditions that previously remained untreatable. Three primary classes of therapeutic oligonucleotides are single-stranded antisense oligonucleotides (ASO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d9ff64736c14a3d121b1b5eacfeee0
https://pubmed.ncbi.nlm.nih.gov/32885957
https://pubmed.ncbi.nlm.nih.gov/32885957