Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marvin D. Schulman"'
Autor:
Hiranthi Jayasuriya, Anne W. Dombrowski, Ziqiang Guan, John G. Ondeyka, Marvin D. Schulman, Sheo B. Singh, John G. Menke, Christine McCallum, Kithsiri Herath, Soojin S Kwon, Karen L. MacNaul, Javier Collado, Nancy S. Hayes, Neelam Sharma
Publikováno v:
The Journal of Antibiotics. 58:559-565
Cholesterol homeostasis is tightly controlled process that involves a variety of regulators including liver X receptors (LXR). Agonists of LXR are expected to increase cholesterol efflux, lower LDL, and raise HDL levels. Screening of a natural produc
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:1737-1741
Avermectins and ivermectins are glycosylated at C-4'' and C-4' by both growing and resting cells of Saccharopolyspora erythraea. The reaction is catalyzed by a glycosyltransferase which is constitutive. The enzyme uses UDP-glucose as the glycosyl don
Publikováno v:
Journal of Biological Chemistry. 265:16965-16970
The nucleotide sugar precursor of the oleandrose units of the avermectins has been purified from a mutant of Streptomyces avermitilis, which does not synthesize any avermectins but which converts avermectin aglycones to their respective disaccharides
Autor:
Marvin D. Schulman, Carolyn L. Ruby, Ziqiang Guan, John G. Menke, Sheo B. Singh, Hiranthi Jayasuriya, Neelam Sharma, Srinivas Kodali, Jun Wang, Kithsiri Herath, Karen L. MacNaul, Andrew Galgoci
Publikováno v:
Journal of natural products. 68(9)
Liver X receptors (LXR) are nuclear hormone receptors that play a critical role in cholesterol homeostasis. They regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol out of cells. LXR agonists are expected to increase c
Autor:
Christine McCallum, Marvin D. Schulman
Publikováno v:
Handbook of Industrial Mycology ISBN: 9780824756550
Handbook of Industrial Mycology
Handbook of Industrial Mycology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dad917b31a23efb5e14171731c69039
https://doi.org/10.1201/9780203970553.ch10
https://doi.org/10.1201/9780203970553.ch10
Autor:
Russell B. Lingham, John G. Ondeyka, Mark Stahlhut, Carolyn L. Ruby, Manuel Sanchez, David B. Olsen, Marvin D. Schulman, Fernando Pelaez, V V Sardana, Nasios Tsipouras, Sanjeev Munshi, Sheo B. Singh
Publikováno v:
Biochemical and biophysical research communications. 324(1)
HIV-1 protease is one of several key enzymes required for the replication and maturation of HIV-1 virus. An almost two-decade research effort by academic and pharmaceutical institutions resulted in the successful commercialization of seven drugs that
Autor:
Marvin D. Schulman, Molly J. Price-Jones, Anne Fowler, John Anson, Russell B. Lingham, Kelvin T. Hughes
Publikováno v:
Journal of biomolecular screening. 5(3)
A screening assay has been developed for hepatitis C virus (HCV) NS3 protease using the scintillation proximity assay (SPA) technology. The sequence of the peptide substrate used was taken from the site cleaved by the enzyme in the mature nonstructur
Publikováno v:
The Journal of antibiotics. 47(3)
Publikováno v:
The Journal of antibiotics. 46(6)
Publikováno v:
Antimicrobial Agents and Chemotherapy. 31:744-747
"Streptomyces avermitilis" mutants defective in the methylation of the avermectins have been isolated and characterized. Four mutant strains, CR-1, CR-2, CR-3, and CR-4, were unable to methylate the oxygen at C5 of the macrolide moiety and produced e