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ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies.

Autor: Chang CA; AbbVie Bay Area, South San Francisco, CA., Emberley E; AbbVie Bay Area, South San Francisco, CA., D'Souza AL; AbbVie Bay Area, South San Francisco, CA., Zhao W; AbbVie Bay Area, South San Francisco, CA., Cosgrove C; AbbVie Inc, North Chicago, IL., Parrish K; AbbVie Inc, North Chicago, IL., Mitra D; AbbVie Inc, North Chicago, IL., Payson E; AbbVie Bay Area, South San Francisco, CA., Oleksijew A; AbbVie Inc, North Chicago, IL., Ellis P; AbbVie Inc, North Chicago, IL., Rodriguez L; AbbVie Inc, North Chicago, IL., Duggan R; AbbVie Inc, North Chicago, IL., Hrusch C; AbbVie Inc, North Chicago, IL., Lasko L; AbbVie Inc, North Chicago, IL., Assaily W; AbbVie Bay Area, South San Francisco, CA., Zheng P; AbbVie Bay Area, South San Francisco, CA., Liu W; AbbVie Bay Area, South San Francisco, CA., Hernandez A Jr; AbbVie Bioresearch Center, Worcester, MA., McCarthy K; AbbVie Bioresearch Center, Worcester, MA., Zhang Z; AbbVie Bay Area, South San Francisco, CA., Rha G; AbbVie Inc, North Chicago, IL., Cao Z; AbbVie Inc, North Chicago, IL., Li Y; AbbVie Inc, North Chicago, IL., Perng O; AbbVie Bay Area, South San Francisco, CA., Campbell J; AbbVie Bay Area, South San Francisco, CA., Zhang G; AbbVie Bay Area, South San Francisco, CA., Curran T; AbbVie Bay Area, South San Francisco, CA., Bruncko M; AbbVie Inc, North Chicago, IL., Marvin CC; AbbVie Inc, North Chicago, IL., Hobson A; AbbVie Bioresearch Center, Worcester, MA., McPherson M; AbbVie Bioresearch Center, Worcester, MA., Uziel T; AbbVie Inc, North Chicago, IL., Pysz MA; AbbVie Bay Area, South San Francisco, CA., Zhao X; AbbVie Bay Area, South San Francisco, CA., Bankovich A; AbbVie Bay Area, South San Francisco, CA., Hayflick J; AbbVie Bay Area, South San Francisco, CA., McDevitt M; AbbVie Bay Area, South San Francisco, CA., Freise KJ; AbbVie Inc, North Chicago, IL., Morgan-Lappe S; AbbVie Inc, North Chicago, IL., Purcell JW; AbbVie Bay Area, South San Francisco, CA.

Publikováno v: Blood [Blood] 2024 Aug 15; Vol. 144 (7), pp. 757-770.

An anti-TNF-glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases.

Autor: McPherson MJ; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Hobson AD; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Hernandez A Jr; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Marvin CC; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, USA., Waegell W; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Goess C; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Oh JZ; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Shi D; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Hayes ME; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Wang L; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Wang L; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Schmidt D; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, USA., Wang Z; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, USA., Pitney V; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., McCarthy K; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Jia Y; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Wang C; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Kang BN; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Bryant S; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Mathieu S; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Ruzek M; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Parmentier J; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., D'Cunha RR; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, USA., Pang Y; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, USA., Phillips L; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Brown NJ; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Xu J; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Graff C; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Tian Y; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Longenecker KL; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, USA., Qiu W; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, USA., Zhu H; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, USA., Liu W; AbbVie Bay Area, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA., Zheng P; AbbVie Bay Area, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA., Bi Y; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA., Stoffel R; AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Mar 20; Vol. 16 (739), pp. eadd8936. Date of Electronic Publication: 2024 Mar 20.

Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC).

Autor: Hobson AD; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Xu J; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Welch DS; AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Marvin CC; AbbVie Inc., 1400 Sheridan Road, North Chicago, Illinois 60064, United States., McPherson MJ; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Gates B; AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Liao X; AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Hollmann M; AbbVie Deutschland GmbH & Co KG, Knollstrasse 50, 67061 Ludwigshafen, Germany., Gattner MJ; AbbVie Deutschland GmbH & Co KG, Knollstrasse 50, 67061 Ludwigshafen, Germany., Dzeyk K; AbbVie Deutschland GmbH & Co KG, Knollstrasse 50, 67061 Ludwigshafen, Germany., Sarvaiya H; AbbVie Inc., 1000 Gateway Blvd, South San Francisco, California 94080, United States., Shenoy VM; AbbVie Inc., 1000 Gateway Blvd, South San Francisco, California 94080, United States., Fettis MM; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Bischoff AK; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Wang L; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Santora LC; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Wang L; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Fitzgibbons J; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Salomon P; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Hernandez A Jr; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Jia Y; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Goess CA; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Mathieu SL; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Bryant SH; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Larsen ME; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Cui B; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Tian Y; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Sep 14; Vol. 66 (17), pp. 12544-12558. Date of Electronic Publication: 2023 Sep 01.

Correction to "Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate".

Autor: Hobson AD, McPherson MJ, Hayes ME, Goess C, Li X, Zhou J, Wang Z, Yu Y, Yang J, Sun L, Zhang Q, Qu P, Yang S, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Santora LC, Wang L, Wang L, Fettis MM, Li X, Marvin CC, Wang Z, Patel MV, Schmidt DL, Li T, Randolph JT, Henry RF, Graff C, Tian Y, Aguirre AL, Shrestha A

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Apr 27; Vol. 66 (8), pp. 6010. Date of Electronic Publication: 2023 Apr 07.