Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Marvin C Gershengorn"'
Autor:
Susanne Neumann, Umesh Padia, Mary Jane Cullen, Elena Eliseeva, Eshel A Nir, Robert F Place, Sarah J Morgan, Marvin C Gershengorn
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
We are developing an orally available small molecule, allosteric TSH receptor (TSHR) agonist for follow up diagnostics of patients with thyroid cancer. The agonist C2 (NCGC00161870) that we have studied so far is a racemic mixture containing equal am
Externí odkaz:
https://doaj.org/article/250d1128135641ce84215a1baf2f9171
Autor:
Liora Segal, Liora S Katz, Hagit Shapira, Judith Sandbank, Elizabeth Geras-Raaka, Marvin C Gershengorn, Yoram Oron
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93879 (2014)
The balance between the adhesion of cancer cells to extracellular matrix and their migratory potential, as well as their proteolytic activity, are important parameters that determine cancer cells invasiveness and metastasis. Since thrombin has been i
Externí odkaz:
https://doaj.org/article/a2ffadeefc454d9d9e7e3af54be2f62b
Publikováno v:
Frontiers in Endocrinology, Vol 3 (2012)
Taltirelin (TAL) is a thyrotropin-releasing hormone (TRH) analog that is approved for use in humans in Japan. In this study, we characterized TAL binding to and signaling by the human TRH receptor (TRH-R) in a model cell system. We found that TAL exh
Externí odkaz:
https://doaj.org/article/3bc5a9102cde479c8a94d4dab09eaa6d
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14423 (2010)
BACKGROUND: Pancreatic adenocarcinoma (PAC) is one of the most intractable malignancies. In order to search for potential new therapeutic targets, we relied on computational methods aimed at identifying transcription factor binding sites (TFBSs) over
Externí odkaz:
https://doaj.org/article/282d205dbb9d4baaa279563f9a6985e6
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Proximity ligation assay (PLA) is a methodology that permits detection of protein-protein closeness, that is, proteins that are within 40 nanometers of each other, in cells or tissues at endogenous protein levels or after exogenous overexpression. It
Externí odkaz:
https://doaj.org/article/1cb9e80cace34ebf833aba6846c8ea5d
Autor:
Marvin C. Gershengorn, Xiangliang Sui, Susanne Neumann, George J. Kahaly, Christine C Krieger
Publikováno v:
J Clin Endocrinol Metab
Context We previously presented evidence that TSH receptor (TSHR)-stimulating autoantibodies (TSAbs) bind to and activate TSHRs but do not bind to IGF1 receptors (IGF1Rs). Nevertheless, we showed that IGF1Rs were involved in thyroid eye disease (TED)
Publikováno v:
Endocrinology
Regulation of thyroid cells by thyrotropin (TSH) and epidermal growth factor (EGF) has been known but different effects of these regulators on proliferation and differentiation have been reported. We studied these responses in primary cultures of hum
Autor:
Daesong Jang, Marvin C. Gershengorn, Sarah J. Morgan, Susanne Neumann, Joanna Klubo-Gwiezdzinska, J. Paul Banga
Publikováno v:
Thyroid
Background: Thyrotropin (TSH) and thyroid-stimulating antibodies (TSAbs) activate TSH receptor (TSHR) signaling by binding to its extracellular domain. TSHR signaling has been studied extensively in animal thyrocytes and in engineered cell lines, and
Publikováno v:
Eur Thyroid J
Graves’ disease (GD) is an autoimmune disease caused in part by thyroid-stimulating antibodies (TSAbs) that activate the thyroid-stimulating hormone receptor (TSHR). In Graves’ hyperthyroidism (GH), TSAbs cause persistent stimulation of thyroid c
Autor:
Joanna Klubo-Gwiezdzinska, Christine C Krieger, Bernice Marcus-Samuels, Susanne Neumann, Sarah S. Malik, Marvin C. Gershengorn, Elena Eliseeva, Daesong Jang
Publikováno v:
Molecular Pharmacology. 97:2-8
The thyrotropin (TSH) receptor (TSHR) signals via G proteins of all four classes and β-arrestin 1. Stimulation of TSHR leads to increasing cAMP production that has been reported as a monotonic dose-response curve that plateaus at high TSH doses. In