Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Marvin C Gershengorn"'
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Proximity ligation assay (PLA) is a methodology that permits detection of protein-protein closeness, that is, proteins that are within 40 nanometers of each other, in cells or tissues at endogenous protein levels or after exogenous overexpression. It
Externí odkaz:
https://doaj.org/article/1cb9e80cace34ebf833aba6846c8ea5d
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
A direct action of thyrotropin (TSH, thyroid-stimulating hormone) on bone precursors in humans is controversial. Studies in rodent models have provided conflicting findings. We used cells derived from a moderately differentiated osteosarcoma stably o
Externí odkaz:
https://doaj.org/article/6e6f83c7e73749a1b545c2c35a6b15d3
Autor:
Alisa Boutin, Christine C. Krieger, Bernice Marcus-Samuels, Joanna Klubo-Gwiezdzinska, Susanne Neumann, Marvin C. Gershengorn
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Thyrotropin hormone (TSH) was reported to exhibit biphasic regulation of cAMP production in human thyroid slices; specifically, upregulation at low TSH doses transitioning to inhibition at high doses. We observed this phenomenon in HEK293 cells overe
Externí odkaz:
https://doaj.org/article/49e79ccc53424a4d88739ab01a3fccf3
Autor:
Marvin C. Gershengorn, Xiangliang Sui, Susanne Neumann, George J. Kahaly, Christine C Krieger
Publikováno v:
J Clin Endocrinol Metab
Context We previously presented evidence that TSH receptor (TSHR)-stimulating autoantibodies (TSAbs) bind to and activate TSHRs but do not bind to IGF1 receptors (IGF1Rs). Nevertheless, we showed that IGF1Rs were involved in thyroid eye disease (TED)
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6561 (2020)
In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (T
Externí odkaz:
https://doaj.org/article/9491ae088505434897e9636050723a1f
Publikováno v:
Endocrinology
Regulation of thyroid cells by thyrotropin (TSH) and epidermal growth factor (EGF) has been known but different effects of these regulators on proliferation and differentiation have been reported. We studied these responses in primary cultures of hum
Autor:
Susanne Neumann, Umesh Padia, Mary Jane Cullen, Elena Eliseeva, Eshel A Nir, Robert F Place, Sarah J Morgan, Marvin C Gershengorn
Publikováno v:
Frontiers in Endocrinology, Vol 7 (2016)
We are developing an orally available small molecule, allosteric TSH receptor (TSHR) agonist for follow up diagnostics of patients with thyroid cancer. The agonist C2 (NCGC00161870) that we have studied so far is a racemic mixture containing equal am
Externí odkaz:
https://doaj.org/article/250d1128135641ce84215a1baf2f9171
Autor:
Daesong Jang, Marvin C. Gershengorn, Sarah J. Morgan, Susanne Neumann, Joanna Klubo-Gwiezdzinska, J. Paul Banga
Publikováno v:
Thyroid
Background: Thyrotropin (TSH) and thyroid-stimulating antibodies (TSAbs) activate TSH receptor (TSHR) signaling by binding to its extracellular domain. TSHR signaling has been studied extensively in animal thyrocytes and in engineered cell lines, and
Publikováno v:
Eur Thyroid J
Graves’ disease (GD) is an autoimmune disease caused in part by thyroid-stimulating antibodies (TSAbs) that activate the thyroid-stimulating hormone receptor (TSHR). In Graves’ hyperthyroidism (GH), TSAbs cause persistent stimulation of thyroid c
Autor:
Joanna Klubo-Gwiezdzinska, Christine C Krieger, Bernice Marcus-Samuels, Susanne Neumann, Sarah S. Malik, Marvin C. Gershengorn, Elena Eliseeva, Daesong Jang
Publikováno v:
Molecular Pharmacology. 97:2-8
The thyrotropin (TSH) receptor (TSHR) signals via G proteins of all four classes and β-arrestin 1. Stimulation of TSHR leads to increasing cAMP production that has been reported as a monotonic dose-response curve that plateaus at high TSH doses. In