Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Immunopathological Factor and a Severity Prognostic Biomarker in COVID-19.

Autor: Toro DM; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Postgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil., da Silva-Neto PV; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Postgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil., de Carvalho JCS; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil., Fuzo CA; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Pérez MM; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Pimentel VE; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Fraga-Silva TFC; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Oliveira CNS; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil.; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Caruso GR; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Vilela AFL; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil., Nobre-Azevedo P; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil.; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Defelippo-Felippe TV; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil., Argolo JGM; Department of General and Specialized Nursing, School of Nursing of Ribeirão Preto-EERP, University of São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil., Degiovani AM; Hospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil., Ostini FM; Hospital Santa Casa de Misericórdia de Ribeirão Preto, Ribeirão Preto 14085-000, SP, Brazil., Feitosa MR; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.; Hospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil., Parra RS; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.; Hospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil., Vilar FC; Hospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil.; Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Gaspar GG; Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Rocha JJRD; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Feres O; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil.; Hospital São Paulo, Ribeirão Preto 14025-100, SP, Brazil., Costa GP; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil., Maruyama SRC; Department of Genetics and Evolution, Center for Biological and Health Sciences, Federal University of São Carlos (UFSCar), São Carlos 13565-905, SP, Brazil., Russo EMS; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Fernandes APM; Department of General and Specialized Nursing, School of Nursing of Ribeirão Preto-EERP, University of São Paulo-USP, Ribeirão Preto 14040-902, SP, Brazil., Santos IKFM; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Malheiro A; Postgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil., Sadikot RT; Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Bonato VLD; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., Cardoso CRB; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Dias-Baruffi M; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Trapé ÁA; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo-USP, Ribeirão Preto 14040-900, SP, Brazil., Faccioli LH; Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto-FCFRP, University of Sao Paulo-USP, Ribeirão Preto 14040-903, SP, Brazil., Sorgi CA; Postgraduate Program in Basic and Applied Immunology-PPGIBA, Institute of Biological Sciences, Federal University of Amazonas-UFAM, Manaus 69080-900, AM, Brazil.; Department of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto-FFCLRP, University of São Paulo-USP, Ribeirão Preto 14040-901, SP, Brazil.; Department of Biochemistry and Immunology, Faculty of Medicine of Ribeirão Preto-FMRP, University of São Paulo-USP, Ribeirão Preto 14049-900, SP, Brazil., ImmunoCovid Consortium Group

Publikováno v: Cells [Cells] 2023 Jul 26; Vol. 12 (15). Date of Electronic Publication: 2023 Jul 26.