Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maruti Naik"'
Publikováno v:
2023 IEEE 8th International Conference for Convergence in Technology (I2CT).
Autor:
Maruti Naik, Praveen Kumar P
Publikováno v:
International Journal for Research in Applied Science and Engineering Technology. 10:869-875
The design of a satisfactory bituminous mix is a complex task due to the wide variation in properties of its constituents such as bitumen, coarse and fine aggregate, filler, etc. The design also depends on the shape and gradation of the aggregates. F
Publikováno v:
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
To evaluate use of sustained low efficiency dialysis (SLED) in critically ill children with acute kidney injury in a resource-limited setting.Observational database cohort study (December 2016 to January 2020).PICU of a tertiary hospital in India.Cri
Publikováno v:
2018 International Conference on Recent Innovations in Electrical, Electronics & Communication Engineering (ICRIEECE).
SPV based irrigation pumps are installed across India. However these irrigation pumps are not widely employed. One of the probable reasons behind this is mismatch of the need and availability of pump ratings to the farmers. Performance results of SPV
Autor:
Rajesh Kalkhambkar, Bheemarao G. Ugarkar, Jon Read, Martin Vogtherr, Beena Paul, Swati Prasad, Adrian Liam Gill, Shantika Bhat, Helen H.J. McMiken, Maruti Naik, Jyothi Bhat, Julie A. Tucker, Kevin J. Embrey, Begur Vasanthkumar Varun, Balachandra Bandodkar, Rani Menon, Syeed Hussein, Janani Venkatraman, Kannan Murugan, Harini Iyer, Anandkumar Raichurkar, Manoranjan Panda
Publikováno v:
Journal of Medicinal Chemistry. 58:753-766
M. tuberculosis thymidylate kinase (Mtb TMK) has been shown in vitro to be an essential enzyme in DNA synthesis. In order to identify novel leads for Mtb TMK, we performed a high throughput biochemical screen and an NMR based fragment screen through
Autor:
Eknath Bellale, Maruti Naik, Varun VB, Anisha Ambady, Ashwini Narayan, Sudha Ravishankar, Vasanthi Ramachandran, Parvinder Kaur, Robert McLaughlin, James Whiteaker, Sapna Morayya, Supreeth Guptha, Sreevalli Sharma, Anandkumar Raichurkar, Disha Awasthy, Vijayshree Achar, Prakash Vachaspati, Balachandra Bandodkar, Manoranjan Panda, Monalisa Chatterji
Publikováno v:
Journal of medicinal chemistry. 57(15)
Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chemistry exploration, we demonstrated chemical opportunities to optimize th
Autor:
Monalisa Chatterji, João Neres, Sreevalli Sharma, Prashanti Madhavapeddi, Vijender Panduga, James D. Whiteaker, Suresh Rudrapatna, Chandan Narayan, Krishna Koushik, Laurent R. Chiarelli, Gajanan Shanbhag, Vaishali Humnabadkar, Gopinath Gorai, Claudia Binda, Sandeep R. Ghorpade, Radha Shandil, Neeraj Dhar, Maria Rosalia Pasca, Stefan Kavanagh, Vasan K. Sambandamurthy, M. R. Manjunatha, K.R. Prabhakar, Vijayashree Achar, John D. McKinney, Neela Dinesh, Naina Hegde, Praveena Manjrekar, François Signorino-Gelo, Parvinder Kaur, Shridhar Narayanan, Jitendar Reddy, Subramanyam J. Tantry, Ashwini Narayan, Sandesh Jatheendranath, Lalit kumar Jena, Tommasi Ruben A, Jyothi Mahadevaswamy, Disha Awasthy, Ramanatha Saralaya, Manoranjan Panda, Bob McLaughlin, Anisha Ambady, Vinayak Hosagrahara, Pravin Iyer, Chandramohan Bathula, Maruti Naik, Giovanna Riccardi, Supreeth Guptha, Sudha Ravishankar, Vasanthi Ramachandran
Publikováno v:
Journal of medicinal chemistry. 57(12)
4-Aminoquinolone piperidine amides (AQs) were identified as a novel scaffold starting from a whole cell screen, with potent cidality on Mycobacterium tuberculosis (Mtb). Evaluation of the minimum inhibitory concentrations, followed by whole genome se
2-Phenylindole and Arylsulphonamide: Novel Scaffolds Bactericidal against Mycobacterium tuberculosis
Autor:
Lava Kumar Naviri, Vasanthi Ramachandran, Vaishali Humnabadkar, Monalisa Chatterji, Radha Nandishaiah, Ashwini Narayan, Sreevalli Sharma, Gopinath Gorai, Neela Dinesh, Lalit kumar Jena, Parvinder Kaur, Gayathri Balakrishnan, Pallavi Khadtare, Manoranjan Panda, Pravin Iyer, Maruti Naik, Sandeep R. Ghorpade, Supreeth Guptha, Jyothi Bhat
Publikováno v:
ACS medicinal chemistry letters. 5(9)
A cellular activity-based screen on Mycobacterium tuberculosis (Mtb) H37Rv using a focused library from the AstraZeneca corporate collection led to the identification of 2-phenylindoles and arylsulphonamides, novel antimycobacterial scaffolds. Both t
Autor:
Jyothi Mahadevaswamy, Naina Hegde, Shridhar Narayanan, Vijender Panduga, Ashwini Narayan, Ramesh R. Kale, Pravin Iyer, Claire Sadler, Parvinder Kaur, Abhishek Srivastava, Chandramohan Bathula, Vinayak Hosagrahara, Sowmya Bharath, K. G. Vishwas, Chandan Narayan, Suresh Solapure, Prashanti Madhavapeddi, James D. Whiteaker, Maruti Naik, Vaishali Humnabadkar, Nilanjana Roy Choudhury, Supreeth Guptha, Monalisa Chatterji, Humphrey Gardner, Anisha Ambady, K.R. Prabhakar, Radha Shandil, Vasan K. Sambandamurthy, Disha Awasthy, Vasanthi Ramachandran, Vijaykamal Ahuja, Jitendar Reddy, Robert E. McLaughlin, Shahul Hameed, Sreevalli Sharma, Pravin S. Shirude, Naveen Kumar, Manjunatha Ramaiah, Vikas Shinde
Publikováno v:
Journal of medicinal chemistry. 56(23)
We report 1,4-azaindoles as a new inhibitor class that kills Mycobacterium tuberculosis in vitro and demonstrates efficacy in mouse tuberculosis models. The series emerged from scaffold morphing efforts and was demonstrated to noncovalently inhibit d
Autor:
Janani Venkatraman, Prashanti Madhavapeddi, Balachandra Bandodkar, Vasan K. Sambandamurthy, Maruti Naik, Pravin S. Shirude, Anupriya Kumar, Vikas Shinde, Radha Nandishaiah, Geoffrey A. Holdgate, Jon Read, Gareth M. Davies, Anisha Ambady, Helen H.J. McMiken, Jyothi Bhat, Shahul Hameed, Naina Hegde, Manoranjan Panda, Kannan Murugan
Publikováno v:
Journal of medicinal chemistry. 56(21)
InhA is a well validated Mycobacterium tuberculosis (Mtb) target as evidenced by the clinical success of isoniazid. Translating enzyme inhibition to bacterial cidality by targeting the fatty acid substrate site of InhA remains a daunting challenge. T