Výsledky vyhledávání - "Maruf M. U. Ali"

Akademický článek

Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones

Autor: Yassin Ben-Khoud, Chao-Sheng Chen, Maruf M. U. Ali

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Hsp70 molecular chaperones are essential components for maintaining protein homeostasis within cells. They interact with substrate or client proteins in a well characterised fashion that is regulated by ATP and supported by co-chaperones. In eukaryot

Externí odkaz: https://doaj.org/article/23553c3b105346ffae070f2f7c82d94c

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Akademický článek

Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response

Autor: Natacha Larburu, Christopher J. Adams, Chao-Sheng Chen, Piotr R. Nowak, Maruf M. U. Ali

Publikováno v: Open Biology, Vol 10, Iss 8 (2020)

Hsp70 chaperones interact with substrate proteins in a coordinated fashion that is regulated by nucleotides and enhanced by assisting cochaperones. There are numerous homologues and isoforms of Hsp70 that participate in a wide variety of cellular fun

Externí odkaz: https://doaj.org/article/0a05b150adeb4c8989ffc75c4c5912ca

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Akademický článek

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1

Autor: Christopher J. Adams, Megan C. Kopp, Natacha Larburu, Piotr R. Nowak, Maruf M. U. Ali

Publikováno v: Frontiers in Molecular Biosciences, Vol 6 (2019)

The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its folding capacity. However, the physiological demands or aberrations

Externí odkaz: https://doaj.org/article/d27d807958cf4c4d93c2aa5d7a0255af

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Akademický článek

UPR Signal Activation by Luminal Sensor Domains

Autor: Maruf M. U. Ali, Marta Carrara, Filippo Prischi

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 3, Pp 6454-6466 (2013)

The unfolded protein response (UPR) is a cell-signaling system that detects the accumulation of unfolded protein within the endoplasmic reticulum (ER) and initiates a number of cellular responses to restore ER homeostasis. The presence of unfolded pr

Externí odkaz: https://doaj.org/article/f25a31dbf34c423087b152fcdb5b436b

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