Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Maruan, Hijazi"'
Autor:
Celia De Los Angeles Colomina Basanta, Marya Bazzi, Maruan Hijazi, Conrad Bessant, Pedro R Cutillas
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1010459 (2023)
Phosphoproteomics allows one to measure the activity of kinases that drive the fluxes of signal transduction pathways involved in biological processes such as immune function, senescence and cell growth. However, deriving knowledge of signalling netw
Externí odkaz:
https://doaj.org/article/6ea4b07a280243fe9d1d668fc29d361f
Autor:
Llara Prieto-Fernandez, Maria de los Angeles Villaronga, Francisco Hermida-Prado, Maruan Hijazi, Irene Montoro-Jimenez, Marta Pevida, Sara Llames, Juan Pablo Rodrigo, Pedro Cutillas, Fernando Calvo, Juana Maria Garcia-Pedrero, Saul Alvarez-Teijeiro
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114176- (2023)
Background: Cancer-associated fibroblasts (CAFs) are major players in tumor-stroma communication, and participate in several cancer hallmarks to drive tumor progression and metastatic dissemination. This study investigates the driving effects of tumo
Externí odkaz:
https://doaj.org/article/6dd7866ca2f549c98b3ef0dc3ad39e35
Autor:
Henry Gerdes, Pedro Casado, Arran Dokal, Maruan Hijazi, Nosheen Akhtar, Ruth Osuntola, Vinothini Rajeeve, Jude Fitzgibbon, Jon Travers, David Britton, Shirin Khorsandi, Pedro R. Cutillas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Artificial intelligence and machine learning promise to transform cancer therapies by accurately predicting the most appropriate drugs to treat individual patients. Here, the authors present an approach which uses omics data to produce ordered lists
Externí odkaz:
https://doaj.org/article/dd9e23dc4fd245f6935c304010512356
Autor:
Celia De Los Angeles Colomina Basanta, Marya Bazzi, Maruan Hijazi, Conrad Bessant, Pedro R. Cutillas
Phosphoproteomics allows one to measure the activity of kinases that drive the fluxes of signal transduction pathways involved in biological processes such as immune function, senescence and growth. However, deriving knowledge of signaling network ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78f64674535569c5cef52a3f3ce0cced
https://doi.org/10.1101/2022.08.04.502751
https://doi.org/10.1101/2022.08.04.502751
Autor:
Miguel A. Cuadros, Maruan Hijazi, David Martín-Oliva, Sandra M. Martín-Guerrero, Julio Plaza-Díaz, Julio Navascués, Francisco Abadía-Molina, Pedro R. Cutillas, Pedro Casado, Vinothini Rajeeve
Publikováno v:
Biochemical Journal. 477:4491-4513
Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyze the transfer of ADP-ribose units from NAD+ to several target proteins involved in cellular stress responses. Using WRL68 (HeLa derivate) cells, we previously showed that PARP-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104b7e1092c7daa50e04c90a9f84b2dc
https://doi.org/10.1042/bcj20200525
https://doi.org/10.1042/bcj20200525
Autor:
Kevin Rouault-Pierre, Federico Pedicona, MARUAN HIJAZI VEGA, Pedro Casado, John Gribben, Pedro Rodriguez Cutillas
Publikováno v:
Science signaling. 15(730)
Most tumor types either fail to respond or become resistant to kinase inhibitors, often because of compensatory prosurvival pathways in the cancer cell’s broader signaling circuitry. Here, we found that intrinsic resistance to kinase inhibitors in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca22c3910ebbc81d3368c9c64ff373d
https://pubmed.ncbi.nlm.nih.gov/35439022
https://pubmed.ncbi.nlm.nih.gov/35439022
Publikováno v:
Nature Biotechnology. 38:493-502
Understanding how oncogenic mutations rewire regulatory-protein networks is important for rationalizing the mechanisms of oncogenesis and for individualizing anticancer treatments. We report a chemical phosphoproteomics method to elucidate the topolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::327b3d57221459496ca48c6ebf579141
https://doi.org/10.1038/s41587-019-0391-9
https://doi.org/10.1038/s41587-019-0391-9
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619353
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43950334b638992247177ffb078b84a8
https://doi.org/10.1007/978-1-0716-1936-0_8
https://doi.org/10.1007/978-1-0716-1936-0_8
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2420
The identification of biomarkers for companion diagnostics is revolutionizing the development of treatments tailored to individual patients in different disease areas including cancer. Precision medicine is most frequently based on the detection of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::deb5871e9368137aa3e1a29f1e706f4d
https://pubmed.ncbi.nlm.nih.gov/34905168
https://pubmed.ncbi.nlm.nih.gov/34905168
Autor:
Maruan Hijazi, Pedro Casado, Nosheen Akhtar, Saul Alvarez-Teijeiro, Vinothini Rajeeve, Pedro R. Cutillas
Publikováno v:
Molecular & Cellular Proteomics. 21:100240
PI3K-mammalian target of rapamycin and MAPK/ERK kinase (MEK)/mitogen-activated protein kinase (MAPK) are the most frequently dysregulated signaling pathways in cancer. A problem that limits the success of therapies that target individual PI3K-MAPK me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05d2e10ee81767785818e9efa064dce
https://doi.org/10.1016/j.mcpro.2022.100240
https://doi.org/10.1016/j.mcpro.2022.100240