Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Martyna O. Urbanek"'
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101023- (2022)
Summary: Here, we present the miRMut protocol to annotate mutations found in miRNA genes based on whole-exome sequencing (WES) or whole-genome sequencing (WGS) results. The pipeline assigns mutation characteristics, including miRNA gene IDs (miRBase
Externí odkaz:
https://doaj.org/article/c93514aaded1443fa6b7b5e670ffd67d
Autor:
Martyna O. Urbanek-Trzeciak, Paulina Galka-Marciniak, Paulina M. Nawrocka, Ewelina Kowal, Sylwia Szwec, Maciej Giefing, Piotr Kozlowski
Publikováno v:
EBioMedicine, Vol 61, Iss , Pp 103051- (2020)
Background: miRNAs are considered important players in oncogenesis, serving either as oncomiRs or suppressormiRs. Although the accumulation of somatic alterations is an intrinsic aspect of cancer development and many important cancer-driving mutation
Externí odkaz:
https://doaj.org/article/f87dc641754e4efbbc051a22d389ccc4
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Trinucleotide repeat expansion disorders (TREDs) are a group of dominantly inherited neurological diseases caused by the expansion of unstable repeats in specific regions of the associated genes. Expansion of CAG repeat tracts in translated regions o
Externí odkaz:
https://doaj.org/article/37572c72bccd4d8cb94bc016d42e2355
Publikováno v:
Methods. 120:49-57
The first methods for visualizing RNAs within cells were designed for simple imaging of specific transcripts in cells or tissues and since then significant technical advances have been made in this field. Today, high-resolution images can be obtained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddef843b86d0897cb6739e8a5c403bf5
https://doi.org/10.1016/j.ymeth.2017.04.002
https://doi.org/10.1016/j.ymeth.2017.04.002
Publikováno v:
Methods. 98:115-123
RNA fluorescence in situ hybridization (FISH) is a widely used technique for detecting transcripts in fixed cells and tissues. Many variants of RNA FISH have been proposed to increase signal strength, resolution and target specificity. The current va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1becc246f4926b92131a9b62c3754bcc
https://doi.org/10.1016/j.ymeth.2015.11.017
https://doi.org/10.1016/j.ymeth.2015.11.017
Autor:
Izabela Makalowska, Marta Olejniczak, Michal Wojciech Szczesniak, Wlodzimierz J. Krzyzosiak, Lukasz Witucki, Martyna O. Urbanek, Edyta Jaworska
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859:306-314
RNA interference triggers such as short interfering RNA (siRNA) or genetically encoded short hairpin RNA (shRNA) and artificial miRNA (sh-miR) are widely used to silence the expression of specific genes. In addition to silencing selected targets, RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65aeba954d2d61ed3f5dc83b001c5ef
https://doi.org/10.1016/j.bbagrm.2015.11.005
https://doi.org/10.1016/j.bbagrm.2015.11.005
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 6, Pp 13259-13286 (2015)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Small noncoding RNAs perform multiple regulatory functions in cells, and their exogenous mimics are widely used in research and experimental therapies to interfere with target gene expression. MicroRNAs (miRNAs) are the most thoroughly investigated r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8005a8000bc4321ecdebfaa09affea33
http://www.mdpi.com/1422-0067/16/6/13259
http://www.mdpi.com/1422-0067/16/6/13259
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Mediators of Inflammation
Mediators of Inflammation
Trinucleotide repeat expansion disorders (TREDs) are a group of dominantly inherited neurological diseases caused by the expansion of unstable repeats in specific regions of the associated genes. Expansion of CAG repeat tracts in translated regions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05dc9f2c18003be569d48cb884a15974
https://doi.org/10.1155/2015/873860
https://doi.org/10.1155/2015/873860
Publikováno v:
Nucleic Acids Research
The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also known as nuclear domains or nuclear subcompartments. These self-organizing structures gather machinery involved in various nuclear activities. Nuclear speckles (NSs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa70770eda5ea0337ad9078114dc276
https://pubmed.ncbi.nlm.nih.gov/28977640
https://pubmed.ncbi.nlm.nih.gov/28977640
Publikováno v:
Frontiers in Cellular Neuroscience
In several human polyglutamine diseases caused by expansions of CAG repeats in the coding sequence of single genes, mutant transcripts are detained in nuclear RNA foci. In polyglutamine disorders, unlike other repeat-associated diseases, both RNA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3970d18474f962c5bf05e78ed73bff87
http://europepmc.org/articles/PMC5368221
http://europepmc.org/articles/PMC5368221