Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Martyna Kuta"'
Autor:
Alexandra L. Petrache, Archie A. Khan, Martin W. Nicholson, Alessandra Monaco, Martyna Kuta-Siejkowska, Shozeb Haider, Stephen Hilton, Jasmina N. Jovanovic, Afia B. Ali
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABAA receptors (GABAARs) as potential therapeutic targets for disorders associated with cognitive deficits, including Alzheimer’s disease (AD), continually fail clin
Externí odkaz:
https://doaj.org/article/5adb6257652149dda4942e7f037cacbc
Publikováno v:
Molecules, Vol 23, Iss 5, p 1134 (2018)
The binding affinities of three carbazole derivatives to the intramolecular G-quadruplex (GQ) DNA formed by the sequence 5′-AGGGAGGGCGCTGGGAGGAGGG-3′, derived from the c-KIT 1 oncogene region, were investigated. All carbazole cationic ligands tha
Externí odkaz:
https://doaj.org/article/cd4eaa5f649a43c88a5cf5283ff904c0
Autor:
Sakineh Kazemi Noureini, Ali Akbar Saboury, Gary N. Parkinson, Barira Islam, Marcin Hoffmann, Hosein Esmaeili, Soraia Khiali, Shozeb Haider, Farzane Abachi, Martyna Kuta, Jiri Sponer
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:2020-2030
Background Natural bioproducts are invaluable resources in drug discovery. Isoquinoline alkaloids of Chelidonium majus constitute a structurally diverse family of natural products that are of great interest, one of them being their selectivity for hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb9b09eaaab96def8b1256c51f96992
https://doi.org/10.1016/j.bbagen.2017.05.002
https://doi.org/10.1016/j.bbagen.2017.05.002
Publikováno v:
Molecules; Volume 23; Issue 5; Pages: 1134
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 5, p 1134 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 5, p 1134 (2018)
The binding affinities of three carbazole derivatives to the intramolecular G-quadruplex (GQ) DNA formed by the sequence 5′-AGGGAGGGCGCTGGGAGGAGGG-3′, derived from the c-KIT 1 oncogene region, were investigated. All carbazole cationic ligands tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea9553b60c830c235ad41e1724cf0e2
Publikováno v:
DNA-targeting Molecules as Therapeutic Agents ISBN: 9781782629924
Quadruplex nucleic acids are discrete higher-order four-stranded structures formed from short repetitive guanine-rich DNA or RNA sequences. They are over-represented in eukaryotic telomeric DNA sequences, in promoter sequences and in untranslated reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::467baba914c5d4d8f7559fc642a774fc
https://doi.org/10.1039/9781788012928-00265
https://doi.org/10.1039/9781788012928-00265
Publikováno v:
New Journal of Chemistry
Structures of adducts formed in the reactions between a model oxoenal and the DNA bases were determined based on 2D NMR spectroscopy. Results obtained from quantum-mechanical studies indicated that two mechanisms can be involved in the generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be8084f432be448f65a2f540e43bb07
Publikováno v:
International journal of biological macromolecules. 114
The interactions of c-myc G-quadruplex with three carbazole derivatives were investigated by UV-Vis spectrophotometry, fluorescence, CD spectroscopy, and molecular modeling. The results showed that a combination of carbazole scaffold functionalized w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f5553655e7e66810a0ccbdabb878d9
https://pubmed.ncbi.nlm.nih.gov/29581003
https://pubmed.ncbi.nlm.nih.gov/29581003
Autor:
Shozeb Haider, Xiangtao Wang, Min Yang, Pedro Ernesto de Resende, Guoxuan Sun, Martyna Kuta, Paul Stapleton
Publikováno v:
Carbohydrate research. 452
Glycosylation is a promising approach to overcome antimicrobial drug resistance. In this study, we investigated Koenigs-Knorr and phase transfer glycosylation on novobiocin. While the former only gave a 4'-OH product, the later produced mainly a kine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6247957cae880e4fe6a20e42edc1e08e
https://pubmed.ncbi.nlm.nih.gov/29096184
https://pubmed.ncbi.nlm.nih.gov/29096184