Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Martyn L. Evans"'
Autor:
Gareth Williams, Richard Morris, John C. Clapham, Xiao H Liu, Shelagh Wilson, Xue J. Cai, Jonathan R.S. Arch, Martyn L. Evans
Publikováno v:
Regulatory Peptides. 104:1-9
Neurons expressing prepro-orexin, the precursor of orexin-A and -B, are found in the lateral hypothalamic area, a region classically implicated in driving feeding. Orexin-A induces feeding transiently when injected centrally, and food intake can be d
Autor:
Jonathan R.S. Arch, Shelagh Wilson, Martyn L. Evans, Ron A. Leslie, Carolyn A. Lister, Gareth R. Williams, Xue J. Cai
Publikováno v:
Diabetes. 50:105-112
Orexins are novel appetite-stimulating peptides expressed in the lateral hypothalamic area (LHA), and their expression is stimulated by hypoglycemia in fasted rats. We investigated activation of orexin and other neurons during insulin-induced hypogly
Autor:
Jonathan R.S. Arch, Richard Morris, Ron A. Leslie, Martyn L. Evans, Gareth Williams, David J. Cutler
Publikováno v:
Peptides. 22:123-128
The lateral hypothalamic area (LHA), a key site involved in the central control of feeding and energy homeostasis, contains populations of neurons that produce the orexin peptides or nitric oxide, two chemical factors that increase food intake. In th
Publikováno v:
Brain Research. 867:62-69
We have explored the neuroprotective efficacy of the cell penetrant caspase inhibitor, Ac-YVAD-cmk, in a hippocampal slice model of neuronal cell death induced by oxygen and glucose deprivation. Organotypic hippocampal slice cultures were prepared fr
Autor:
David J. Cutler, Shelagh Wilson, Ron A. Leslie, Sara Patel, Gareth Williams, Richard Morris, Robin E. Buckingham, Jonathan R.S. Arch, Vimal Sheridhar, Trevor A. Wattam, Martyn L. Evans, Stephen Dudley Holmes
Publikováno v:
Peptides. 20:1455-1470
The orexins are recently identified appetite-stimulating hypothalamic peptides. We used immunohistochemistry to map orexin-A and orexin-B immunoreactivity in rat brain, spinal cord, and some peripheral tissues. Orexin-A- and orexin-B-immunoreactive c
Publikováno v:
Neuroscience Letters. 271:57-60
The novel anticonvulsant SB-204269 inhibits epileptiform afterdischarges induced by high K+ in rat hippocampal slices. Its effects on voltage-gated Na+ currents, measured from cultured hippocampal neurones using whole cell patch clamp, were compared
Autor:
Martyn L. Evans, Penny D. King, John Morris Evans, Wai N. Chan, Thomas P. Blackburn, Mervyn Thompson, Colin A. Campbell, Tania O. Stean, Duncan Cooper, Neil Upton, Alison M. Ray, Hugh J. Herdon
Publikováno v:
British Journal of Pharmacology. 121:1679-1686
1. Earlier optimization of structure-activity relationships in a novel series of 4-(benzoylamino)-benzopyrans, led to the discovery of SB-204269 (trans-(+)-6-acetyl-4S-(4-fluorobenzoylamino)-3,4-dihydro-2, 2-dimethyl-2H-benzo[b]pyran-3R-ol, hemihydra
Autor:
Thomas C. Hamilton, William J. Price, Jenny C. Roberts, Martyn L. Evans, Nigel I. Wood, Sara Patel, Colin A. Campbell, Giora Z. Feuerstein, Susan J. Smith, Chris D. Benham, Thomas Henry Smithkline Beecham Brown, Penny D. King, A. Jackie Hunter, Nicole A. Samson, Mark H Harries, Frank C. Barone, Jackie E. Meakin, David Gwyn Cooper, Karen L. Murkitt, Alan L. Rothaul
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 17:421-429
The effects of SB 206284A, 1-[7-(4-benzyloxyphenoxy)heptyl] piperidine hydrochloride, have been investigated in vitro on calcium and sodium currents in rat-cultured dorsal root ganglion (DRG) neurones and potassium-mediated calcium influx in rat syna
Publikováno v:
Europe PubMed Central
Dorsal root ganglion cells (DRGs) exhibit 3 types of voltage-dependent calcium channels. We have cultured DRGs from 2- to 4-day-old rat pups and obtained whole-cell patch-clamp recordings of calcium-channel currents after 1-5 days in culture. The cal
Publikováno v:
Synapse. 8:22-29
Autoradiographic receptor binding studies using 125I-LSD (2-[125I]lysergic acid diethyamide) revealed intense labelling on the soma of a symmetrically located pair of cells in the abdominal ganglion of Aplysia californica. This binding was blocked by