Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martyn J. James"'
Publikováno v:
The Journal of biological chemistry. 295(20)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b48e74e7a94459ca3ecd21990eda530
https://pubmed.ncbi.nlm.nih.gov/14688273
https://pubmed.ncbi.nlm.nih.gov/14688273
Publikováno v:
Lupus. 22:657-663
Variations at the ITGAM gene, which encodes for the CD11b chain of the Mac-1 (alphaMbeta2; CD11b/CD18; complement receptor-3) integrin, is one of the strongest genetic risk factors for systemic lupus erythematosus (SLE). More specifically, a genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e6cc6efdad3bc62303209c53cdc2e2
https://doi.org/10.1177/0961203313491851
https://doi.org/10.1177/0961203313491851
Publikováno v:
Journal of Bone and Mineral Research. 21:1034-1044
We compared gene expression profiles between Runx2 null mutant mice and their wildtype littermates. Most Runx2-dependent genes in bones were different from those in teeth, implying that the target genes of Runx2 are tissue-dependent. In vitro experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426c19a2ac718d50cb6d48c93c5e4886
https://doi.org/10.1359/jbmr.060413
https://doi.org/10.1359/jbmr.060413
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
Autor:
Irma Thesleff, Mark Tummers, Alea A. Mills, Marja L. Mikkola, Johanna Laurikkala, Martyn J. James
Publikováno v:
Development. 133:1553-1563
Heterozygous germline mutations in p63 , a transcription factor of the p53 family, result in abnormal morphogenesis of the skin and its associated structures, including hair follicles and teeth. In mice lacking p63 , all ectodermal organs fail to dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823f9114171f4371188aaf64febf1cc7
https://doi.org/10.1242/dev.02325
https://doi.org/10.1242/dev.02325
Publikováno v:
Journal of Dental Research. 84:138-143
Heterozygous mutations in the RUNX2 ( CBFA1) gene cause cleidocranial dysplasia, characterized by multiple supernumerary teeth. This suggests that Runx2 inhibits successional tooth formation. However, in Runx2 knockout mice, molar development arrests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdef7695974813ea0ad1466d7c6c8de
https://doi.org/10.1177/154405910508400206
https://doi.org/10.1177/154405910508400206
Autor:
Peter C. Cook, Martyn J. James, David Gavin Glass, Terhi Savinko, Colin Watts, Susanna C. Fagerholm, Christian Gawden-Bone, Hwee San Lek, Vicky L. Morrison, Katarzyna M. Grzes, Owain R. Millington, Andrew S. MacDonald
Publikováno v:
Nature communications
The actin cytoskeleton has been reported to restrict signalling in resting immune cells. Beta2-integrins, which mediate adhesion and cytoskeletal organization, are emerging as negative regulators of myeloid cell-mediated immune responses, but the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5632320b8c9067fa3cf831f64c6e3432
https://doi.org/10.1038/ncomms6359
https://doi.org/10.1038/ncomms6359
Publikováno v:
Molecular Microbiology.
Salmonella enterica serovar Typhimurium is a Gram-negative pathogen capable of respiration with a number of terminal electron acceptors. Tetrathionate reductase is important for the infection process and is encoded by the ttrBCA operon where TtrA and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae5cfa24f04c360c6f7d9ab1da759853
https://doi.org/10.1111/mmi.12373
https://doi.org/10.1111/mmi.12373
Autor:
Martyn J. James, Pascal Schneider, Johanna Laurikkala, Risto Jaatinen, Marja Pummila, Marja L. Mikkola, Ingrid Fliniaux, Irma Thesleff
Publikováno v:
Development, vol. 134, no. 1, pp. 117-125
Ectodermal organogenesis is regulated by inductive and reciprocal signalling cascades that involve multiple signal molecules in several conserved families. Ectodysplasin-A (Eda), a tumour necrosis factor-like signalling molecule, and its receptor Eda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b6ffb14840abdee5d2acc1c3fdb08c
https://pubmed.ncbi.nlm.nih.gov/17164417
https://pubmed.ncbi.nlm.nih.gov/17164417
Publikováno v:
J Biol Chem
Regulation of ribosomal RNA gene transcription by RNA polymerase I (Pol I) is fundamental to ribosome biogenesis and therefore protein translation capacity and cell growth, yet little is known of the key signaling cascades involved. We show here that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a42f630c80620f9d7e797789c9d16cb
https://pubmed.ncbi.nlm.nih.gov/32414913
https://pubmed.ncbi.nlm.nih.gov/32414913
Publikováno v:
Gene expression patterns : GEP. 4(5)
We have examined the mRNA expression pattern of the murine expressed sequence tag (EST) clone AI842353 in embryonic and early postnatal mice. Expression was strongly and specifically localised to developing bones and odontoblasts in teeth, therefore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6d8909d3e4f8f3567dfb0f2acbc16f
https://pubmed.ncbi.nlm.nih.gov/15261838
https://pubmed.ncbi.nlm.nih.gov/15261838