Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Martyn, Inman"'
Autor:
Patricio Sánchez, Cristian O. Salas, Sebastián Gallardo‐Fuentes, Alondra Villegas, Nicolás Veloso, Jessica Honores, Martyn Inman, Mauricio Isaacs, Renato Contreras, Christopher J. Moody, Jonathan Cisterna, Iván Brito, Ricardo A. Tapia
Publikováno v:
Chemistrybiodiversity. 19(6)
The successful application of fragment-based drug discovery strategy for the efficient synthesis of phenoxy- or phenylamino-2-phenyl-benzofuran, -benzoxazole and -benzothiazole quinones is described. Interestingly, in the final step of the synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d95c103b8e1916ad63b8e5315f45d9b
https://pubmed.ncbi.nlm.nih.gov/35581163
https://pubmed.ncbi.nlm.nih.gov/35581163
Autor:
Anqi Yao, Sarah J. Storr, Martyn Inman, Lucy Barwell, Christopher J. Moody, Stewart G. Martin
The thioredoxin (Trx) system, a key antioxidant pathway, represents an attractive target for cancer therapy. This study investigated the chemotherapeutic and radiosensitising effects of a novel Trx reductase (TrxR) inhibitor, IQ10, on brain cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f956d820084334886a12bfffb6073cda
https://doi.org/10.21203/rs.3.rs-987333/v1
https://doi.org/10.21203/rs.3.rs-987333/v1
Autor:
Anqi, Yao, Sarah J, Storr, Martyn, Inman, Lucy, Barwell, Christopher J, Moody, Stewart G, Martin
Publikováno v:
Molecular neurobiology. 59(6)
The thioredoxin (Trx) system, a key antioxidant pathway, represents an attractive target for cancer therapy. This study investigated the chemotherapeutic and radiosensitising effects of a novel Trx reductase (TrxR) inhibitor, IQ10, on brain cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fdac66228a143091e793e4b984d18770
https://pubmed.ncbi.nlm.nih.gov/35344158
https://pubmed.ncbi.nlm.nih.gov/35344158
Autor:
Martyn Inman, Katie Ruffell, Christopher J. Hayes, Michael T. Green, Simon M. Nicolle, William Lewis, Frances R. Smith, Christopher J. Moody
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 27(55)
Diazophosphonates, readily prepared from α-ketophosphonates by oxidation of the corresponding hydrazones in batch or in flow, are useful partners in 1,3-dipolar cycloaddition reactions to alkynes to give N-H pyrazoles, including the first intramolec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d42ea6079b57e572c00e8e561767e6
https://pubmed.ncbi.nlm.nih.gov/34425034
https://pubmed.ncbi.nlm.nih.gov/34425034
Autor:
Martyn Inman, Stewart G. Martin, Christopher J. Moody, Sarah J. Storr, Nurul Akmaryanti Abdullah
Publikováno v:
Investigational New Drugs
SummaryRadiotherapy is an effective treatment modality for breast cancer but, unfortunately, not all patients respond fully with a significant number experiencing local recurrences. Overexpression of thioredoxin and thioredoxin reductase has been rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606f3c473b344f9ec8bbe7b4b225f952
Publikováno v:
The Journal of Organic Chemistry. 83:10595-10601
An intriguing hypothesis that latrunculin A, a well-known natural product, might have undergone transformation into the unprecedented thiopyrone CTP-431 upon long-term storage in methanol is advanced. Thus opening of the hemiacetal of latrunculin A,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f23f572aef515efc5e08081d40f8f
https://doi.org/10.1021/acs.joc.8b01258
https://doi.org/10.1021/acs.joc.8b01258
Publikováno v:
Organic letters. 19(13)
The cyclic dodecapeptides wewakazole and wewakazole B have been synthesized by a divergent strategy via a common tris-proline containing oxazole octapeptide and two separate bis-oxazole containing tetrapeptide units, followed by peptide coupling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93392bb887bff8ecdeb5060959412022
https://pubmed.ncbi.nlm.nih.gov/28617610
https://pubmed.ncbi.nlm.nih.gov/28617610
Autor:
Christopher J. Moody, Martyn Inman
Publikováno v:
European Journal of Organic Chemistry. 2013:2179-2187
The reaction of enamines and bromoquinones in the presence of copper(II) acetate and potassium carbonate results in a regiospecific synthesis of indolequinones. The reaction is broad in scope and scalable and provides a route to the core structure th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1127dbed3cf53f7215c10c74fa90baad
https://doi.org/10.1002/ejoc.201201597
https://doi.org/10.1002/ejoc.201201597
Autor:
Christopher J. Moody, Martyn Inman
Publikováno v:
Chem. Sci.. 4:29-41
Indoles, both naturally occurring and synthetic, exhibit wide-ranging biological activity. Unusual and complex molecular architectures occur among their natural derivatives. As a result, this important ring system continues to attract attention from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::542992fc00ae7280d6210fb362920f1e
https://doi.org/10.1039/c2sc21185h
https://doi.org/10.1039/c2sc21185h
Autor:
H. Ali Dondas, Nigel M. Groome, Martyn Inman, Ronald Grigg, Roger M. Phillips, Colin A. Kilner, Elghareeb E. Elboray
Publikováno v:
Chemistry - A European Journal. 19:2180-2184
Naturally occurring indole-3-carbinol and 3,3-diindolylmethane show bioactivity in a number of disparate disease areas, including cancer, prompting substantial synthetic analogue activity. We describe a new approach to highly functionalised derivativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c69e0b65a55f37dd56f4e1abbac1a6
https://doi.org/10.1002/chem.201202647
https://doi.org/10.1002/chem.201202647