Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Martyn, Chidgey"'
Autor:
Claudia Fogl, Fiyaz Mohammed, Caezar Al-Jassar, Mark Jeeves, Timothy J. Knowles, Penelope Rodriguez-Zamora, Scott A. White, Elena Odintsova, Michael Overduin, Martyn Chidgey
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Plakin proteins link cell junctions to cytoskeletal frameworks, and their disruption within epithelial and cardiac muscle cells cause skin blistering diseases and cardiomyopathies. Here the authors use structural biology approaches to reveal the mech
Externí odkaz:
https://doaj.org/article/e7f4b72653954877a76e2efd1c2dacdd
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69767 (2013)
Envoplakin, periplakin and desmoplakin are cytoskeletal proteins that provide structural integrity within the skin and heart by resisting shear forces. Here we reveal the nature of unique hinges within their plakin domains that provides divergent deg
Externí odkaz:
https://doaj.org/article/39cc115b28824d7cb99f3b033410e9cb
Autor:
Martyn Chidgey, Fiyaz Mohammed
Publikováno v:
Journal of Structural Biology. 213:107749
In this graphical review we focus on the structural characteristics of desmosomal proteins, their interactions with each other and with the intermediate filament cytoskeleton. The wealth of structural information that is now available allows predicti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36a44602ebc583d37e38afe8c1515e1
https://doi.org/10.1016/j.jsb.2021.107749
https://doi.org/10.1016/j.jsb.2021.107749
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 313:G478-G491
Krüppel-like factor 5 (KLF5) is a member of the zinc finger family of transcription factors that regulates homeostasis of the intestinal epithelium. Previous studies suggested an indispensable role of KLF5 in maintaining intestinal barrier function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a2055e82d829b7bf27189122375c9c
https://doi.org/10.1152/ajpgi.00172.2017
https://doi.org/10.1152/ajpgi.00172.2017
Autor:
Michael Overduin, Timothy J. Knowles, Penelope Rodriguez-Zamora, Elena Odintsova, Jitendra Kumar, Mark Jeeves, Pooja Sridhar, Martyn Chidgey, Catharine A. Trieber, Claudia Fogl, Fiyaz Mohammed, Caezar Al-Jassar, Tzu-Han Huang
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Plakin proteins form connections that link the cell membrane to the intermediate filament cytoskeleton. Their interactions are mediated by a highly conserved linker domain through an unresolved mechanism. Here analysis of the human periplakin linker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6813fd8fb40f02e1be50c35c14fe6ba4
https://pubmed.ncbi.nlm.nih.gov/32081916
https://pubmed.ncbi.nlm.nih.gov/32081916
Publikováno v:
Journal of Molecular Biology. 386:531-543
The desmoglein-specific cytoplasmic region (DSCR) is a conserved region of unknown structure and function that uniquely defines the desmoglein family of cell adhesion molecules. It is the site of caspase cleavage during apoptosis, and its mutation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812d839ccba922b114cab745d6ba78d6
https://doi.org/10.1016/j.jmb.2008.12.054
https://doi.org/10.1016/j.jmb.2008.12.054
Autor:
Martyn Chidgey, David R. Garrod
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778(3):572-587
Desmosomes are intercellular junctions of epithelia and cardiac muscle. They resist mechanical stress because they adopt a strongly adhesive state in which they are said to be hyper-adhesive and which distinguishes them from other intercellular junct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86337a61ee4852396587ef8649f7d95
Autor:
Martyn Chidgey, David Garrod
Publikováno v:
The Cadherin Superfamily ISBN: 9784431560319
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50dd9972d421e2a8e84201786d8f485f
https://doi.org/10.1007/978-4-431-56033-3_7
https://doi.org/10.1007/978-4-431-56033-3_7
Autor:
C Dawson, Martyn Chidgey
Publikováno v:
British Journal of Cancer
Much evidence now attests to the importance of desmosomes and their constituents in cancer. Alterations in the expression of desmosomal components could contribute to the progression of the disease by modifying intracellular signal transduction pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20df5cf189abb121e299594ce0b4e2cc
https://doi.org/10.1038/sj.bjc.6603808
https://doi.org/10.1038/sj.bjc.6603808
Autor:
Anita J. Merritt, Kuichun Zhu, Denise Youngs, Conrad Smith, Martyn Chidgey, David R. Garrod, Rhian Picton
Publikováno v:
Biochemical Journal. 380:757-765
Desmocollins (Dscs) are desmosomal cadherins that exhibit differentiation-specific patterns of expression in the epidermis. Dsc3 expression is strongest in basal cell layers, whereas Dsc1 is largely confined to upper, terminally differentiating strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f683cdf83dacf93f558096e7e50b579f
https://doi.org/10.1042/bj20040077
https://doi.org/10.1042/bj20040077