Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Marty Straume"'
Autor:
Gerard Gadal, Allison Mackay, Heather Chin, Monica Antenos, Jonathan LaMarre, Marty Straume, Jeremy A. Simpson, Ron J. Johnson, Elena V. Tsimakouridze, Patsy Huether, Michael J. Sole, Peter S. Podobed, Tami A. Martino, Gordon M. Kirby
Publikováno v:
Chronobiology International. 29:810-821
There is critical demand in contemporary medicine for gene expression markers in all areas of human disease, for early detection of disease, classification, prognosis, and response to therapy. The integrity of circadian gene expression underlies card
Autor:
Erin K. Davis, Gabriella B. Lundkvist, Gene D. Block, Michael T. Sellix, Mikael Nygård, Marty Straume, Krister Kristensson
Publikováno v:
Journal of Biological Rhythms. 25:92-102
African sleeping sickness is characterized by alterations in rhythmic functions. It is not known if the disease affects the expression of clock genes, which are the molecular basis for rhythm generation. We used a chronic rat model of experimental sl
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 293:R1430-R1437
Molecular gene cycling is useful for determining body time of day (BTOD) with important applications in personalized medicine, including cardiovascular disease and cancer, our leading causes of death. However, it impractically requires repetitive inv
Autor:
Neelam Khaper, Fayez Dawood, Marty Straume, Denise D. Belsham, Horia Pribiag, Peter P. Liu, Michael J. Sole, Martin R. Ralph, Jennifer A. Chalmers, Nazneen Tata, Peter H. Backx, Paul Lee, Tami A. Martino
Publikováno v:
Hypertension. 49:1104-1113
Day/night rhythms are recognized as important to normal cardiovascular physiology and timing of adverse cardiovascular events; however, their significance in disease has not been determined. We demonstrate that day/night rhythms play a critical role
Autor:
Ronald M. Evans, Ruth T. Yu, Xiaoyong Yang, Weimin He, David J. Mangelsdorf, Angie L. Bookout, Marty Straume, Michael Downes
Publikováno v:
Cell. 126:801-810
As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR) expression in key metabolic tissues may contribute to circadian entrainment of nutrient and energy metabolism. Surveying the diurnal expression profiles of
Autor:
Fang Cai, Marty Straume, Peter Liu, Tami A. Martino, Maria G. Trivieri, Michael J. Sole, Martin R. Ralph, Nazneen Tata, Sara Arab, Denise D. Belsham
Publikováno v:
Journal of Molecular Medicine. 82:256-264
Molecular circadian oscillators have recently been identified in heart and many other peripheral organs; however, little is known about the physiologic significance of circadian gene cycling in the periphery. While general temporal profiles of gene e
Autor:
Pierre Lefebvre, Elizabeth Welsh, B. M. Kirby, Johannes D. Veldhuis, Susan S. McIntyre, Lise L. Kjems, Marty Straume, Dongchang Yang, Peter C. Butler
Publikováno v:
Diabetes. 50:2001-2012
Most insulin is secreted in discrete pulses at an interval of approximately 6 min. Increased insulin secretion after meal ingestion is achieved through the mechanism of amplification of the burst mass. Conversely, in type 2 diabetes, insulin secretio
Autor:
Bin Han, John B. Hogenesch, Stacey L. Harmer, Tong Zhu, Hur-Song Chang, Joel A. Kreps, Marty Straume, Xun Wang, Steve A. Kay
Publikováno v:
Science. 290:2110-2113
Like most organisms, plants have endogenous biological clocks that coordinate internal events with the external environment. We used high-density oligonucleotide microarrays to examine gene expression in Arabidopsis and found that 6% of the more than
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(16)
Circadian organization changes with age, but we do not know the extent to which age-related changes are the result of alterations in the central pacemakers, the peripheral oscillators, or the coupling mechanisms that hold the system together. By usin
Autor:
Satchidananda Panda, Andrew I. Su, Marina P. Antoch, John B. Hogenesch, Marty Straume, Peter G. Schultz, Andrew B. Schook, Brooke H. Miller, Steve A. Kay, Joseph S. Takahashi
Publikováno v:
Cell. 109(3)
In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling to identify cycling transcripts in the SCN and in the liv