Výsledky vyhledávání - "Marty Olbrot"

Abstract 2249: Development and validation of a pharmacodynamic (PD) assay for TOS-358, the first covalent inhibitor of PI3Kα in clinical development

Autor: John R. MacDougall, Raymond Mak, John Bradley, Allison Simpson, Claire May, Lan Wei, Kendra Ouellette, Marty Olbrot, Jimmy Blair, Neil Dhawan, Wei Chen

Publikováno v: Cancer Research. 83:2249-2249

TOS-358 is a first-in-class covalent inhibitor of PI3Kα and is currently in clinical development in a variety of solid malignancies. We have developed a fit-for-purpose pharmacodynamic assay to evaluate the target occupancy of TOS-358 in in vitro an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4a456949391642472ad772103280841
https://doi.org/10.1158/1538-7445.am2023-2249

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