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pro vyhledávání: '"Marty Hodge"'
Autor:
Bruce Jaffee, Robert Bennett, Mattia Karen M, Swanee Jacutin-Porte, Gregory J. LaRosa, Shaowu Chen, Shannon Chi, Marty Hodge, Anthony J. Coyle, Geraldine C Harriman, Celeste Harrington, Douglas F. Burdi, Kenneth G. Carson, Jose-Angel Gonzalo, Vikram Kansra, Timothy D. Ocain, Zhan Shi, Wei Yin
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(11)
The identification, optimization, and structure-activity relationship (SAR) of small-molecule CCR4 antagonists is described. An initial screening hit with micromolar potency was identified that was optimized to sub-micromolar binding potency by enant