Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Marty A. Fernandez"'
Autor:
Liviu Aron, Chenxi Qiu, Zhen Kai Ngian, Marianna Liang, Derek Drake, Jaejoon Choi, Marty A. Fernandez, Perle Roche, Emma L. Bunting, Ella K. Lacey, Sara E. Hamplova, Monlan Yuan, Michael S. Wolfe, David A. Bennett, Eunjung A. Lee, Bruce A. Yankner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Many aging individuals accumulate the pathology of Alzheimer’s disease (AD) without evidence of cognitive decline. Here we describe an integrated neurodegeneration checkpoint response to early pathological changes that restricts further di
Externí odkaz:
https://doaj.org/article/e84a41f3caaa44a194226f2627e04640
Autor:
Christina R. Muratore, Constance Zhou, Meichen Liao, Marty A. Fernandez, Walter M. Taylor, Valentina N. Lagomarsino, Richard V. Pearse, II, Heather C. Rice, Joseph M. Negri, Amy He, Priya Srikanth, Dana G. Callahan, Taehwan Shin, Monica Zhou, David A. Bennett, Scott Noggle, J. Christopher Love, Dennis J. Selkoe, Tracy L. Young-Pearse
Publikováno v:
Stem Cell Reports, Vol 9, Iss 6, Pp 1868-1884 (2017)
Summary: Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course. A major unresolved question is the basis for this selective neuronal vulnerability. Aβ, whic
Externí odkaz:
https://doaj.org/article/9f03abb62b1343ab8aa8f519af659d78
Autor:
YouJin Lee, Morgan R Miller, Marty A Fernandez, Elizabeth L Berg, Adriana M Prada, Qing Ouyang, Michael Schmidt, Jill L Silverman, Tracy L Young-Pearse, Eric M Morrow
Publikováno v:
Brain
Brain : a journal of neurology, vol 145, iss 9
Brain : a journal of neurology, vol 145, iss 9
Loss-of-function mutations in the X-linked endosomal Na+/H+ exchanger 6 (NHE6) cause Christianson syndrome in males. Christianson syndrome involves endosome dysfunction leading to early cerebellar degeneration, as well as later-onset cortical and sub
Autor:
Eugene Lee, Morgan Miller, Marty A. Fernandez, Elizabeth Berg, Adriana Prada, Jill Silverman, Tracy Young‐Pearse, Eric Morrow
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Marty A. Fernandez, Fatmata Bah, Li Ma, YouJin Lee, Michael Schmidt, Elizabeth Welch, Eric M. Morrow, Tracy L. Young-Pearse
Publikováno v:
Stem cell reports. 17(9)
Disruption of endolysosomal and autophagy-lysosomal systems is increasingly implicated in neurodegeneration. Sodium-proton exchanger 6 (NHE6) contributes to the maintenance of proper endosomal pH, and loss-of function mutations in the X-linked NHE6 l
Autor:
Valentina N. Lagomarsino, Vilas Menon, Courtney R. Benoit, Tracy L. Young-Pearse, Scott Noggle, Hyo Lee, Daniel Paull, Lei Liu, Maria A. Vicent, Marty A. Fernandez, Duc M. Duong, Christina Muratore, Monica Zhou, Daniel Felsky, Vicky Chou, Jonathan M.S. Stricker, Fatmata Bah, Dennis J. Selkoe, Seeley B. Fancher, Badri N. Vardarajan, Shinya Tasaki, Chris Gaiteri, Jishu Xu, Amy He, Yi-Chen Hsieh, Philip L. De Jager, Julie P. Merchant, Eric B. Dammer, Nicholas T. Seyfried, Richard V. Pearse, Allan I. Levey, Elizabeth A. Vinton, Hector Martinez, David A. Bennett, Lori B. Chibnik
Publikováno v:
Neuron
We have generated a controlled and manipulable resource that captures genetic risk for Alzheimer’s disease: iPSC lines from 53 individuals coupled with RNA and proteomic profiling of both iPSC-derived neurons and from brain tissue of the same indiv
Autor:
Michael S. Wolfe, Karine Laulagnier, André Miguel Lopes Miranda, Gilbert Di Paolo, Rebecca Williamson, Marty A. Fernandez, Rémy Sadoul
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Amyloid plaques, a neuropathological hallmark of Alzheimer's disease, are largely composed of amyloid β (Aβ) peptide, derived from cleavage of amyloid precursor protein (APP) by β- and γ-secretases. The endosome is increasingly recognized as an i
Autor:
Dana G. Callahan, Walter M. Taylor, Marty A. Fernandez, Monica Zhou, J. Christopher Love, Priya Srikanth, Joseph Negri, Tracy L. Young-Pearse, Taehwan Shin, Constance Zhou, Dennis J. Selkoe, Mei-Chen Liao, Heather C. Rice, Richard V. Pearse, Valentina N. Lagomarsino, David A. Bennett, Amy He, Christina Muratore, Scott Noggle
Publikováno v:
Elsevier
Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 6, Pp 1868-1884 (2017)
Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 6, Pp 1868-1884 (2017)
Authors Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course. A major unresolved question is the basis for this selective neuronal vulnerability. Aβ which pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2cefc1664cebd36d4d0e7d8271ba43
https://hdl.handle.net/1721.1/124803
https://hdl.handle.net/1721.1/124803
Autor:
Marty A. Fernandez, Roxana M. Coman, Arthur H. Robbins, Anthony Sochet, Robert McKenna, C.T Gilliland, Maureen M. Goodenow, Ben M. Dunn
Publikováno v:
Biochemistry. 47:731-743
Fourteen subtype B and C protease variants have been engineered in an effort to study whether the preexistent baseline polymorphisms, by themselves or in combination with drug resistance mutations, differentially alter the biochemical and structural
Autor:
Michael S. Wolfe, Marty A. Fernandez
Publikováno v:
Alzheimer's & Dementia. 11