Výsledky vyhledávání - "Martoriati, A."

Akademický článek

Synthesis and Biological Activity of a New Indenoisoquinoline Copper Derivative as a Topoisomerase I Inhibitor

Autor: Caroline Molinaro, Nathalie Wambang, Sylvain Pellegrini, Natacha Henry, Marc F. Lensink, Emmanuelle Germain, Till Bousquet, Jérôme de Ruyck, Katia Cailliau, Lydie Pélinski, Alain Martoriati

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 19, p 14590 (2023)

Topoisomerases are interesting targets in cancer chemotherapy. Here, we describe the design and synthesis of a novel copper(II) indenoisoquinoline complex, WN198. The new organometallic compound exhibits a cytotoxic effect on five adenocarcinoma cell

Externí odkaz: https://doaj.org/article/17729bc66443431f8505b52447232bd2

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Akademický článek

Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization

Autor: Ingrid Fliniaux, Guillaume Marchand, Caroline Molinaro, Mathieu Decloquement, Alain Martoriati, Matthieu Marin, Jean-François Bodart, Anne Harduin-Lepers, Katia Cailliau

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Sialic acids are a family of 9-carbon monosaccharides with particular physicochemical properties. They modulate the biological functions of the molecules that carry them and are involved in several steps of the reproductive process. Sialoglycoprotein

Externí odkaz: https://doaj.org/article/576b5ff02c514f5d90590d3768c6c63d

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Akademický článek

Plasmodium berghei leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development

Autor: Aline Fréville, Bénédicte Gnangnon, Annie Z. Tremp, Caroline De Witte, Katia Cailliau, Alain Martoriati, El Moukthar Aliouat, Priyanka Fernandes, Cerina Chhuon, Olivier Silvie, Sabrina Marion, Ida Chiara Guerrera, Johannes T. Dessens, Christine Pierrot, Jamal Khalife

Publikováno v: Open Biology, Vol 12, Iss 8 (2022)

Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechanisms underlying its regulation remain to be deciphered. Here, we report the functional characterization of the Plasmodium berghei leucine-rich repeat

Externí odkaz: https://doaj.org/article/449b50bd714546fb85baee771f03edd7

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Akademický článek

A Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas

Autor: Caroline Molinaro, Nathalie Wambang, Till Bousquet, Anne-Sophie Vercoutter-Edouart, Lydie Pélinski, Katia Cailliau, Alain Martoriati

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Topoisomerases, targets of inhibitors used in chemotherapy, induce DNA breaks accumulation leading to cancer cell death. A newly synthesized copper(II) indenoisoquinoline complex WN197 exhibits a cytotoxic effect below 0.5 µM, on MDA-MB-231, HeLa, a

Externí odkaz: https://doaj.org/article/bc1f449418844aa3b2776757d324a9b4

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Akademický článek

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

Publikováno v: Neurobiology of Disease, Vol 157, Iss , Pp 105426- (2021)

LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD). Dephosphorylation at LRRK2's S910/S935/S955/S973 phosphosite cluster is observed in several con

Externí odkaz: https://doaj.org/article/1fd99d9a1cef4426b7f99882df3c1bd9

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Akademický článek

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