Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Marton Tompa"'
Publikováno v:
Case Reports in Neurology, Vol 16, Iss 1, Pp 188-195 (2024)
Introduction: Stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (CONDSIAS) is an autosomal recessive disorder caused by biallelic pathogenic variants in the ADPRS gene. Since its first description in 2018, less than f
Externí odkaz:
https://doaj.org/article/3b07bc0345d043b295c3640e776bc1c8
Autor:
Marton Tompa, Bence Galik, Peter Urban, Bela Istvan Kajtar, Zoltan Kraboth, Attila Gyenesei, Attila Miseta, Bernadette Kalman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7564 (2024)
OMICS methods brought significant advancements to the understanding of tumor cell biology, which transformed the treatment and prognosis of several cancers. Clinical practice and outcomes, however, changed significantly less in the case of glioblasto
Externí odkaz:
https://doaj.org/article/e070a1a9dbfe46a9bfac28cfeb6bc2df
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2174 (2022)
Background: Immune evasion in glioblastoma (GBM) shields cancer cells from cytotoxic immune response. Methods: We investigated CpG methylation in promoters, genes, and pathways in 22 pairs of formalin-fixed paraffin-embedded sequential (FFPE) GBM usi
Externí odkaz:
https://doaj.org/article/eb872353024c4af79141d48997c05f19
Autor:
Alexandra Maráczi, Bernadette Kalman, Ádám Nagy, Ferenc Garzuly, Marton Tompa, Zoltan Kraboth
Publikováno v:
Ideggyogyaszati szemle. 74(9-10)
Aberrant activation of the Wnt pathway contributes to differentiation and maintenance of cancer stem cells underlying gliomagenesis. The aim of our research was to determine as to what degrees some Wnt markers are expressed in gliomas of different gr
Publikováno v:
Brain Research. 1718:114-125
Glioblastoma (GBM) is a highly heterogeneous and aggressive brain tumor. Comprehensive genomic and transcriptomic analyses revealed that GBM segregates into three subgroups with characteristic signaling pathways. The Wnt pathway recently received inc
Autor:
Marton Tompa, Ferenc Garzuly, Lajos Takáts, Bernadette Kalman, Ferenc Kálovits, Katalin Somogyi
Publikováno v:
Ideggyógyászati szemle. 72:141-144
Secretory meningioma is a rare form of meningiomas which differentiates from the meningothelial subtype. It is characterized by significant peritumor edema and distinct immunohistochemical and molecular genetic profiles. We present a middle aged fema
Publikováno v:
Pathology-Research and Practice
Background Wnt signaling plays important roles in tumorigenesis, invasiveness and therapeutic resistance of glioblastoma (GBM). Methods We simultaneously investigated six Wnt pathway markers (Wnt5a, Fzd-2, beta-catenin, Wnt3a, Wnt7b, Fzd-10) at epige
Autor:
Attila Gyenesei, Bernadette Kalman, Béla Kajtár, Zoltan Kraboth, Bence Galik, Marton Tompa, Attila Miseta, Péter Urbán
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Glioblastoma is the most aggressive form of brain tumors. A better understanding of the molecular mechanisms leading to its evolution is essential for the development of treatments more effective than the available modalities. Here, we aim to
Publikováno v:
NeuroMolecular Medicine. 20:437-451
Glioblastoma (GBM), a highly lethal brain tumor, has been comprehensively characterized at the molecular level with the identification of several potential treatment targets. Data concerning the Wnt pathway are relatively sparse, but apparently very
Publikováno v:
Ideggyógyászati szemle. 71:237-247
Oncogenesis is related to a sequential accumulation of somatic mutations. Comprehensive characterizations of the genomic landscapes have been completed recently for several tumors, glioblastoma being among the first ones. Our own translational resear