Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity

Autor: Siva A. Vanapalli, Rashmi Kamble, Aldo Jongejan, Siddhartha Gupta, Marte Molenaars, Simone Denis, Georges E. Janssens, Marton L. Toth, Bauke V. Schomakers, Rebecca L. McIntyre, Michael A. Petr, Mizanur Rahman, Morten Scheibye-Knudsen, Riekelt H. Houtkooper

Publikováno v: McIntyre, R L, Denis, S W, Kamble, R, Molenaars, M, Petr, M, Schomakers, B V, Rahman, M, Gupta, S, Toth, M L, Vanapalli, S A, Jongejan, A, Scheibye-Knudsen, M, Houtkooper, R H & Janssens, G E 2021, ' Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF-16-induced longevity ', Aging Cell, vol. 20, no. 8, pp. e13381 . https://doi.org/10.1111/acel.13381
Aging cell, 20(8):e13381. Wiley-Blackwell
Aging Cell

Transcriptome‐based drug screening is emerging as a powerful tool to identify geroprotective compounds to intervene in age‐related disease. We hypothesized that, by mimicking the transcriptional signature of the highly conserved longevity interve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040057db7bc3bee99c989b88ae357a7c
https://doi.org/10.1111/acel.13381

C-elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

Autor: Christian Neri, KC Q Nguyen, Christopher V. Gabel, Marton L. Toth, J. Alex Parker, Ryan J. Guasp, Girish Harinath, Meghan Lee Arnold, Monica Driscoll, Ilija Melentijevic, David H. Hall, Daniel G. Taub

Publikováno v: Nature
Nature, Nature Publishing Group, 2017, 542 (7641), pp.367+. ⟨10.1038/nature21362⟩
Nature, 2017, 542 (7641), pp.367+. ⟨10.1038/nature21362⟩

Adult neurons from Caenorhabditis elegans can extrude large membrane-surrounded vesicles, known as exophers, containing protein aggregates and dysfunctional organelles that threaten neuronal homeostasis. Monica Driscoll and colleagues show that in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423cadf2d54348eaea6d880aeec65179
https://hal.archives-ouvertes.fr/hal-01545495

Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis

Autor: J. Alex Parker, Jason R. Neuswanger, Skyler Hunter, Marton L. Toth, Elena M. Vayndorf, Barbara E. Taylor, Monica Driscoll, Courtney Scerbak, Christian Neri

Publikováno v: npj Aging and Mechanisms of Disease
npj Aging and Mechanisms of Disease, 2016, 2, pp.16001. ⟨10.1038/npjamd.2016.1⟩
npj Aging and Mechanisms of Disease, Nature, 2016, 2, pp.16001. ⟨10.1038/npjamd.2016.1⟩

Understanding cellular outcomes, such as neuronal remodeling, that are common to both healthy and diseased aging brains is essential to the development of successful brain aging strategies. Here, we used Caenorhabdits elegans to investigate how the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5f56b6306f998749e7301385497033
https://hal.science/hal-01545501

3D Amplitude and Phase Imaging Using Flow-scanning Tomography

Autor: Monica Driscoll, Marton L. Toth, Nicolas C. Pégard, Jason W. Fleischer

Publikováno v: Imaging and Applied Optics 2014.

We combine a microfluidic channel and hybrid space-angle measurement to observe live biomaterial in motion. We experimentally demonstrate the technique by co-registering 3D absorption and 3D differential-phase-contrast images on live, freely swimming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5652dfde3ae15688157df076049b3f0
https://doi.org/10.1364/dh.2014.dw2b.6

Chapter 30 Autophagy in Caenorhabditis elegans

Autor: Gabriella Pásti, Marton L. Toth, Attila L. Kovács, Tímea Sigmond, Tibor Vellai, Krisztina Takács-Vellai, János Barna

Autophagy (cellular self-eating) is a highly regulated, lysosome-mediated catabolic process of eukaryotic cells to segregate by a special membrane and subsequently degrade their own constituents during development or starvation. Electron microscopy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a786b274f445d9df2b47846d9bb26b7
https://doi.org/10.1016/s0076-6879(08)03230-8