Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Marton I. Siklos"'
Autor:
Gregory R.J. Thatcher, Judy L. Bolton, Marton I. Siklos, Rui Xiong, Bradley T. Michalsen, Robert A. Scism, Emily N. Thayer, Yijin Wang, Shuai Wang, Sujeewa C. Piyankarage, Jaewoo Choi, R. Esala P. Chandrasena, Hitisha Patel, L.P. Madhubhani P. Hemachandra
The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER) and to chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c9bdf2f7a62eabcf8004690574fdef4
https://doi.org/10.1158/1940-6207.c.6544512
https://doi.org/10.1158/1940-6207.c.6544512
Autor:
Gregory R.J. Thatcher, Judy L. Bolton, Marton I. Siklos, Rui Xiong, Bradley T. Michalsen, Robert A. Scism, Emily N. Thayer, Yijin Wang, Shuai Wang, Sujeewa C. Piyankarage, Jaewoo Choi, R. Esala P. Chandrasena, Hitisha Patel, L.P. Madhubhani P. Hemachandra
PDF file - 391K, Supplementary Figure S1: Recombinant COMT (10 microg/mL) was incubated with S-(5'-adenosyl)-L-methionine (500 nM) and raloxifene, DMA, or bazadoxifene (1 microM ) at 37 degrees C for 5 minutes prior to the addition of 6,7-dihydroxyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdad968c2164fd8129f4d51c4467a09
https://doi.org/10.1158/1940-6207.22524975.v1
https://doi.org/10.1158/1940-6207.22524975.v1
Autor:
Gregory R. J. Thatcher, Irida Kastrati, Svitlana D. Brovkovych, Jonna Frasor, Marton I. Siklos
Publikováno v:
Hormones and Cancer. 8:135-142
Nearly 75% of breast tumors express estrogen receptor (ER), and will be treated with endocrine therapy, such as selective estrogen receptor modulator (SERM), tamoxifen, or aromatase inhibitors. Despite their proven success, as many as 40-50% of ER+ t
Autor:
Rui Xiong, Marton I. Siklos, Jaewoo Choi, Bradley T. Michalsen, Robert A. Scism, R. Esala P. Chandrasena, Emily N. Thayer, Sujeewa C. Piyankarage, Yijin Wang, Shuai Wang, L. P. Madhubhani P. Hemachandra, Judy L. Bolton, Hitisha K. Patel, Gregory R. J. Thatcher
Publikováno v:
Cancer Prevention Research. 7:505-515
The risk of developing hormone-dependent cancers with long-term exposure to estrogens is attributed both to proliferative, hormonal actions at the estrogen receptor (ER) and to chemical carcinogenesis elicited by genotoxic, oxidative estrogen metabol
Autor:
Emily N. Pierce, Vladislav A. Litosh, Gregory R. J. Thatcher, Yue-Ting Wang, Marton I. Siklos, Sujeewa C. Piyankarage, Tareisha L. Dunlap
Publikováno v:
Chemical research in toxicology. 29(7)
Electrophilic reactive intermediates resulting from drug metabolism have been associated with toxicity and off-target effects and in some drug discovery programs trigger NO-GO decisions. Many botanicals and dietary supplements are replete with such r
Autor:
Vladislav A. Litosh, Subhasish Tapadar, Faisal Saeed, Agnieszka Staniszewski, Li W. Shen, Hong Zhang, Marton I. Siklos, Isaac T. Schiefer, Ottavio Arancio, Mauro Fa, Pavel A. Petukhov, Gregory R. J. Thatcher, Jenny Libien, Andrew F. Teich
Publikováno v:
J Alzheimers Dis
Alzheimer’s disease, one of the most important brain pathologies associated with neurodegenerative processes, is related to overactivation of calpain-mediated proteolysis. Previous data showed a compelling efficacy of calpain inhibition against abn
Autor:
Gregory R. J. Thatcher, Irida Kastrati, Lamiaa El-Shennawy, Gergana Georgieva, Emily N. Thayer, Marton I. Siklos, Jonna Frasor, Esther L. Calderon-Gierszal
Publikováno v:
The Journal of biological chemistry. 291(7)
In breast tumors, activation of the nuclear factor κB (NFκB) pathway promotes survival, migration, invasion, angiogenesis, stem cell-like properties, and resistance to therapy--all phenotypes of aggressive disease where therapy options remain limit
Autor:
Hitisha K. Patel, Aditya S. Vaidya, Marton I. Siklos, Hazem Abdelkarim, Emma Mendonca, Pavel A. Petukhov, Gregory R. J. Thatcher
Breast cancer remains a significant cause of death in women, and few therapeutic options exist for estrogen receptor negative (ER (-)) cancers. Epigenetic reactivation of target genes using histone deacetylase (HDAC) inhibitors has been proposed in E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40aeab9a794ff673e4342187a1470147
https://europepmc.org/articles/PMC3962780/
https://europepmc.org/articles/PMC3962780/
Autor:
Vaishali Sinha, Isaac T. Schiefer, Gregory R. J. Thatcher, Mauro Fa, Robert A. Scism, Michael Brunsteiner, R. Esala P. Chandrasena, Vladislav A. Litosh, Subhasish Tapadar, Ehsan Tavassoli, Gihani T. Wijewickrama, Marton I. Siklos, Ottavio Arancio, Pavel A. Petukhov
Publikováno v:
Journal of medicinal chemistry. 56(15)
Hyperactivation of the calcium-dependent cysteine protease calpain 1 (Cal1) is implicated as a primary or secondary pathological event in a wide range of illnesses and in neurodegenerative states, including Alzheimer's disease (AD). E-64 is an epoxid
Autor:
Marton I. Siklos, Esther L. Calderon-Gierszal, Irida Kastrati, Gregory R. J. Thatcher, Jonna Frasor
Publikováno v:
Cancer Research. 76:4716-4716
Despite major advances in breast cancer treatment, successful therapy outcome is limited to early detection of cancer at the primary organ. Therapy options for aggressive, advanced stage, metastatic and recurring cancers are limited and this translat