Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Autor: Brem, Jürgen, Panduwawala, Tharindi, Hansen, Jon Ulf, Hewitt, Joanne, Liepins, Edgars, Donets, Pawel, Espina, Laura, Farley, Alistair J. M., Shubin, Kirill, Campillos, Gonzalo Gomez, Kiuru, Paula, Shishodia, Shifali, Krahn, Daniel, Leśniak, Robert K., Schmidt (Adrian), Juliane, Calvopiña, Karina, Turrientes, María-Carmen, Kavanagh, Madeline E., Lubriks, Dmitrijs, Hinchliffe, Philip, Langley, Gareth W., Aboklaish, Ali F., Eneroth, Anders, Backlund, Maria, Baran, Andrei G., Nielsen, Elisabet I., Speake, Michael, Kuka, Janis, Robinson, John, Grinberga, Solveiga, Robinson, Lindsay, McDonough, Michael A., Rydzik, Anna M., Leissing, Thomas M., Jimenez-Castellanos, Juan Carlos, Avison, Matthew B., Da Silva Pinto, Solange, Pannifer, Andrew D., Martjuga, Marina, Widlake, Emma, Priede, Martins, Hopkins Navratilova, Iva, Gniadkowski, Marek, Belfrage, Anna Karin, Brandt, Peter, Yli-Kauhaluoma, Jari, Bacque, Eric, Page, Malcolm G. P., Björkling, Fredrik, Tyrrell, Jonathan M., Spencer, James, Lang, Pauline A., Baranczewski, Pawel, Cantón, Rafael, McElroy, Stuart P., Jones, Philip S., Baquero, Fernando, Suna, Edgars, Morrison, Angus, Walsh, Timothy R., Schofield, Christopher J.

Publikováno v: Nature Chemistry; 20210101, Issue: Preprints p1-10, 10p

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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.

Autor: Brem J; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. jurgen.brem@chem.ox.ac.uk., Panduwawala T; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Hansen JU; Statens Serum Institut, Copenhagen, Denmark., Hewitt J; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Liepins E; Latvian Institute of Organic Synthesis, Riga, Latvia., Donets P; Latvian Institute of Organic Synthesis, Riga, Latvia., Espina L; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Farley AJM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Shubin K; Latvian Institute of Organic Synthesis, Riga, Latvia., Campillos GG; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Kiuru P; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Shishodia S; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Krahn D; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Leśniak RK; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Schmidt Adrian J; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Calvopiña K; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Turrientes MC; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., Kavanagh ME; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Lubriks D; Latvian Institute of Organic Synthesis, Riga, Latvia., Hinchliffe P; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Langley GW; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Charles River Laboratories, Saffron Walden, UK., Aboklaish AF; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Eneroth A; Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden., Backlund M; Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden., Baran AG; Latvian Institute of Organic Synthesis, Riga, Latvia., Nielsen EI; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Speake M; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Kuka J; Latvian Institute of Organic Synthesis, Riga, Latvia., Robinson J; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Grinberga S; Latvian Institute of Organic Synthesis, Riga, Latvia., Robinson L; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., McDonough MA; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Rydzik AM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Research and Early Development, Respiratory & Immunology, AstraZeneca, Mölndal, Sweden., Leissing TM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Jimenez-Castellanos JC; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.; Chemical Biology of Antibiotics, Centre for Infection & Immunity (CIIL), Pasteur Institute, INSERM U1019 - CNRS UMR 9017, Lille, France., Avison MB; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Da Silva Pinto S; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Pannifer AD; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Martjuga M; Latvian Institute of Organic Synthesis, Riga, Latvia., Widlake E; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Priede M; Latvian Institute of Organic Synthesis, Riga, Latvia., Hopkins Navratilova I; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Gniadkowski M; Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland., Belfrage AK; Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden., Brandt P; Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden.; Beactica Therapeutics AB, Uppsala, Sweden., Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Bacque E; Evotec Infectious Diseases Lyon, Marcy l'Etoile, France., Page MGP; Jacobs University Bremen gGmbH, Bremen, Germany., Björkling F; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Tyrrell JM; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK.; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Spencer J; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Lang PA; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Baranczewski P; Department of Pharmacy, SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics Facility, Uppsala University, Uppsala, Sweden., Cantón R; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., McElroy SP; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Jones PS; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Baquero F; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., Suna E; Latvian Institute of Organic Synthesis, Riga, Latvia., Morrison A; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Walsh TR; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Schofield CJ; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk.

Publikováno v: Nature chemistry [Nat Chem] 2022 Jan; Vol. 14 (1), pp. 15-24. Date of Electronic Publication: 2021 Dec 13.