Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells

Autor: Sebastiaan T. A. Koenders, Lukas S. Wijaya, Martje N. Erkelens, Alexander T. Bakker, Vera E. van der Noord, Eva J. van Rooden, Lindsey Burggraaff, Pasquale C. Putter, Else Botter, Kim Wals, Hans van den Elst, Hans den Dulk, Bogdan I. Florea, Bob van de Water, Gerard J. P. van Westen, Reina E. Mebius, Herman S. Overkleeft, Sylvia E. Le Dévédec, Mario van der Stelt

Publikováno v: ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)

Externí odkaz: https://doaj.org/article/989e2de45d314bdeb9af0694f21eb017

Intestinal Macrophages Balance Inflammatory Expression Profiles via Vitamin A and Dectin-1-Mediated Signaling

Autor: Martje N. Erkelens, Gera Goverse, Tanja Konijn, Rosalie Molenaar, Marieke R. Beijer, Jan Van den Bossche, Kyra E. de Goede, Sanne G. S. Verberk, Wouter J. de Jonge, Joke M. M. den Haan, Reina E. Mebius

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Tissue resident intestinal macrophages are known to exhibit an anti-inflammatory phenotype and produce little pro-inflammatory cytokines upon TLR ligation, allowing symbiotic co-existence with the intestinal microbiota. However, upon acute events suc

Externí odkaz: https://doaj.org/article/7c1b2ccba2044b309c010d925ddfa5de

Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells

Autor: Hans den Dulk, Reina E Mebius, Eva J. van Rooden, Hans van den Elst, Pasquale C Putter, Bob van de Water, Else Botter, Gerard J. P. van Westen, Alexander T Bakker, Vera E. van der Noord, Bogdan I. Florea, Mario van der Stelt, Kim Wals, Sylvia E. Le Dévédec, Sebastiaan T A Koenders, Herman S. Overkleeft, Lukas S Wijaya, Martje N. Erkelens, Lindsey Burggraaff

Publikováno v: ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)
ACS Central Science, 5(12), 1965-1974
ACS Central Science, 5(12), 1965-1974. American Chemical Society
ACS Central Science
Koenders, S T A, Wijaya, L S, Erkelens, M N, Bakker, A T, van der Noord, V E, van Rooden, E J, Burggraaff, L, Putter, P C, Botter, E, Wals, K, van den Elst, H, den Dulk, H, Florea, B I, van de Water, B, van Westen, G J P, Mebius, R E, Overkleeft, H S, Le Dévédec, S E & van der Stelt, M 2019, ' Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells ', ACS Central Science, vol. 5, no. 12, pp. 1965-1974 . https://doi.org/10.1021/acscentsci.9b01022

Retinaldehyde dehydrogenases belong to a superfamily of enzymes that regulate cell differentiation and are responsible for detoxification of anticancer drugs. Chemical tools and methods are of great utility to visualize and quantify aldehyde dehydrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b18f0ce494d673ba0a4dba8ef3c0464
https://doaj.org/article/989e2de45d314bdeb9af0694f21eb017

Retinoic Acid and Immune Homeostasis

Autor: Reina E. Mebius, Martje N. Erkelens

Publikováno v: Erkelens, M N & Mebius, R E 2017, ' Retinoic Acid and Immune Homeostasis : A Balancing Act ', Trends in Immunology, vol. 38, no. 3, pp. 168-180 . https://doi.org/10.1016/j.it.2016.12.006

In the immune system, the vitamin A metabolite retinoic acid (RA) is known for its role in inducing gut-homing molecules in T and B cells, inducing regulatory T cells (Tregs), and promoting tolerance. However, it was suggested that RA can have a broa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264ae71bf1ade668799a3735dd5a1b69
https://doi.org/10.1016/j.it.2016.12.006

Impact of Viral Infections on Hematopoiesis: From Beneficial to Detrimental Effects on Bone Marrow Output

Autor: Martje N. Erkelens, Martijn A. Nolte, Maria Fernanda Pascutti

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 7 (2016)
Pascutti, M F, Erkelens, M N & Nolte, M A 2016, ' Impact of Viral Infections on Hematopoiesis: From Beneficial to Detrimental Effects on Bone Marrow Output ', Frontiers in Immunology: Molecular Innate Immunity, vol. 7 . https://doi.org/10.3389/fimmu.2016.00364
Frontiers in Immunology: Molecular Innate Immunity, 7. Frontiers Media S.A.
Europe PubMed Central
Frontiers in immunology, 7. Frontiers Media S.A.

The ability of the bone marrow (BM) to generate the copious amounts of blood cells required on a daily basis depends on a highly orchestrated process of proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs). This proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f17e5c07bd369a448e7f56731dc849a
https://pubmed.ncbi.nlm.nih.gov/27695457