Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Martje, Tönjes"'
Autor:
Jenny Schlesinger, Markus Schueler, Marcel Grunert, Jenny J Fischer, Qin Zhang, Tammo Krueger, Martin Lange, Martje Tönjes, Ilona Dunkel, Silke R Sperling
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001313 (2011)
The transcriptome, as the pool of all transcribed elements in a given cell, is regulated by the interaction between different molecular levels, involving epigenetic, transcriptional, and post-transcriptional mechanisms. However, many previous studies
Externí odkaz:
https://doaj.org/article/72cd5d310afe4fc48a30165758214c33
Autor:
Bernhard Radlwimmer, Mario Hlevnjak, Wei Wang, Kathrin V. Schmidt, M. Kirchgäßner, A. E. Lykkesfeldt, Verena Thewes, Guido Sauter, Martje Tönjes, Stefanie Heck, Ulrich Deuschle, Magdalena Schlotter, Hans-Peter Sinn, P. Windisch, Nathaniel Melling, Jürgen G. Okun, Peter Lichter, S. Kaulfuss, Andreas Schneeweiss, Yonghe Wu, Marc Zapatka, Niclas Kneisel, Reinhard Büttner, Ronald Simon, Tobias Anzeneder, H. Hess-Stumpp, Petra Schroeter
Publikováno v:
Oncogene. 36:4124-4134
Antiestrogen-resistant and triple-negative breast tumors pose a serious clinical challenge because of limited treatment options. We assessed global gene expression changes in antiestrogen-sensitive compared with antiestrogen-resistant (two tamoxifen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5113c500b31d5571ace1e5ec0ba2f1
https://doi.org/10.1038/onc.2017.32
https://doi.org/10.1038/onc.2017.32
Autor:
Simon, Raffel, Mattia, Falcone, Niclas, Kneisel, Jenny, Hansson, Wei, Wang, Christoph, Lutz, Lars, Bullinger, Gernot, Poschet, Yannic, Nonnenmacher, Andrea, Barnert, Carsten, Bahr, Petra, Zeisberger, Adriana, Przybylla, Markus, Sohn, Martje, Tönjes, Ayelet, Erez, Lital, Adler, Patrizia, Jensen, Claudia, Scholl, Stefan, Fröhling, Sibylle, Cocciardi, Patrick, Wuchter, Christian, Thiede, Anne, Flörcken, Jörg, Westermann, Gerhard, Ehninger, Peter, Lichter, Karsten, Hiller, Rüdiger, Hell, Carl, Herrmann, Anthony D, Ho, Jeroen, Krijgsveld, Bernhard, Radlwimmer, Andreas, Trumpp
Publikováno v:
Nature. 560(7718)
In Extended Data Fig. 1a of this Letter, the flow cytometry plot depicting the surface phenotype of AML sample DD08 was a duplicate of the plot for AML sample DD06. Supplementary Data 4 has been added to the Supplementary Information of the original
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::898b3358465737146714ba41d5ad6159
https://pubmed.ncbi.nlm.nih.gov/29144447
https://pubmed.ncbi.nlm.nih.gov/29144447
Autor:
Petra Zeisberger, Patrizia Jensen, Sibylle Cocciardi, Lars Bullinger, Adriana Przybylla, Anne Flörcken, Jeroen Krijgsveld, Andreas Trumpp, Bernhard Radlwimmer, Gerhard Ehninger, Stefan Fröhling, Mattia Falcone, Carl Herrmann, Lital Adler, Patrick Wuchter, Jenny Hansson, Yannic Nonnenmacher, Gernot Poschet, Peter Lichter, Jörg Westermann, Anthony D. Ho, Martje Tönjes, Christoph Lutz, Rüdiger Hell, Carsten Bahr, Wei Wang, Andrea Barnert, Simon Raffel, Claudia Scholl, Ayelet Erez, Niclas Kneisel, Markus Sohn, Christian Thiede, Karsten Hiller
Publikováno v:
Nature. 551(7680)
The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely uncertain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebae6a75b572ad45ac83ce2de9d5c93
https://pubmed.ncbi.nlm.nih.gov/30069041
https://pubmed.ncbi.nlm.nih.gov/30069041
Autor:
David Capper, Tatjana Starzetz, Karl-Heinz Plate, Felix Sahm, B. Schwamb, Michel Mittelbronn, Venkatesh Kolluru, Patrick N. Harter, Martin Zörnig, Bernhard Radlwimmer, Martje Tönjes, U. Rabenhorst, Anna-Eva Blank, Peter Baumgarten, Ralf J. Rieker, Hiroko Ohgaki, A. von Deimling, Donat Kögel
Publikováno v:
Neuropathology and Applied Neurobiology. 40:205-216
Aims The Far Upstream Element [FUSE] Binding Protein 1 (FUBP1) regulates target genes, such as the cell cycle regulators MYC and p21. FUBP1 is up-regulated in many tumours and acts as an oncoprotein by stimulating proliferation and inhibiting apoptos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f10b6458a0b8da9492b17464e43de133
https://doi.org/10.1111/nan.12088
https://doi.org/10.1111/nan.12088
Autor:
Rosario M. Piro, Anders Lindroth, Rainer König, Timothy A. Chan, Daniela Karra, Irene Weibrecht, Hendrik Witt, Susan M. Hutson, Adele K. Addington, Bernhard Radlwimmer, Yoon Jung Park, Sebastian Barbus, Kathrin V. Schmidt, Jürgen G. Okun, Magdalena Schlotter, Alfa H.C. Bai, Wei Wang, Ralf Kemkemer, Volker Hovestadt, Benito Campos, Claudio Gavino Rolli, Sevin Turcan, Christel Herold-Mende, Manfred Jugold, Jörg Felsberg, Guido Reifenberger, Dieter Lemke, Peter Lichter, Stefan M. Pfister, Martje Tönjes, Sabrina Pleier, William Edmund Hull, Christoph Plass, Dominik Sturm
Publikováno v:
Nature Medicine
Here we show that glioblastoma express high levels of branched-chain amino acid transaminase 1 (BCAT1), the enzyme that initiates the catabolism of branched-chain amino acids (BCAAs). Expression of BCAT1 was exclusive to tumors carrying wild-type iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e550b45aa368aab3dd31029987b9dc58
https://doi.org/10.1038/nm.3217
https://doi.org/10.1038/nm.3217
Autor:
Jenny Schlesinger, Kerstin Schulz, Sophia Schoenhals, Michael F. Berger, Silke Sperling, Ilona Dunkel, Timm Haack, Martha L. Bulyk, Salim Abdelilah-Seyfried, Huanhuan Cui, David Meierhofer, Martje Tönjes, Elena Cano, Sascha Sauer
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research (London)
Europe PubMed Central
Nucleic Acids Research (London)
Europe PubMed Central
DPF3 (BAF45c) is a member of the BAF chromatin remodeling complex. Two isoforms have been described, namely DPF3a and DPF3b. The latter binds to acetylated and methylated lysine residues of histones. Here, we elaborate on the role of DPF3a and descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabd5c10d92bb17fbe2c2eb24a25074b
http://edoc.mdc-berlin.de/15202/1/15202oa.pdf
http://edoc.mdc-berlin.de/15202/1/15202oa.pdf
Autor:
Nada Jabado, Djihad Hadjadj, Nesrin Sabha, Marcel Kool, Andrey Korshunov, Adam M. Fontebasso, Jeremy Schwartzentruber, Damien Faury, Gelareh Zadeh, Sidney Croul, Guido Reifenberger, Jacek Majewski, Steffen Albrecht, Peter M. Siegel, Noha Gerges, Xiaoyang Liu, Adam Fleming, Zhifeng Dong, David T.W. Jones, Martje Tönjes, Dong-Anh Khuong-Quang, Stefan M. Pfister
Publikováno v:
Acta Neuropathologica. 124:615-625
Gliomas are the most common primary brain tumors in children and adults. We recently identified frequent alterations in chromatin remodelling pathways including recurrent mutations in H3F3A and mutations in ATRX (α-thalassemia/mental-retardation-syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f438e073f9d7f7b09ff3fac11ae18c7d
https://doi.org/10.1007/s00401-012-1031-3
https://doi.org/10.1007/s00401-012-1031-3
Autor:
Andreas von Deimling, Hendrik Witt, Arnulf Pekrun, André Nantel, Krzystof Zakrzewski, Volker Hovestadt, Wolfram Scheurlen, Andrey Korshunov, Martin Ebinger, Marc Zapatka, Natalie Jäger, Tobias Rausch, Wolfgang Roggendorf, Michael C. Frühwald, Peter Lichter, Almos Klekner, David T.W. Jones, Andreas E. Kulozik, Martin U. Schuhmann, Elke Pfaff, Olaf Witt, Marina Ryzhova, Martje Tönjes, V. Peter Collins, Steffen Albrecht, Cindy Zhang, Koichi Ichimura, Uri Tabori, Damien Faury, Marcel Kool, David Malkin, Peter Hauser, Dong Anh Khuong Quang, Karine Jacob, Pedro Castelo-Branco, Till Milde, Jeremy Schwartzentruber, Jan O. Korbel, Abhijit Guha, Anders Lindroth, Peter M. Siegel, Matthias Dürken, CM Kramm, Guido Reifenberger, Miklós Garami, Jeffrey Atkinson, Jacek Majewski, Adam M. Fontebasso, Pierre Lepage, Nada Jabado, Pawel P. Liberski, Alexandre Montpetit, Jörg Felsberg, Stefan M. Pfister, Thomas Hielscher, Magdalena Zakrzewska, Carolin Konermann, László Bognár, Xiaoyang Liu, Christoph Plass, Dominik Sturm, Zhifeng Dong
Publikováno v:
Nature. 482:226-231
Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases. To explore the genetic events underlying this distinction,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca415b36a9ff52c8116a68d76fa6632
https://doi.org/10.1038/nature10833
https://doi.org/10.1038/nature10833
Autor:
Volker Hovestadt, László Bognár, Olaf Witt, Holger Hauch, Michael D. Taylor, Xiaoyang Liu, V. Peter Collins, Sebastian Bender, Rogier Versteeg, Peter Lichter, Arnulf Pekrun, Marc Zapatka, Gregor Von Komorowski, Tom Mikkelsen, Nada Jabado, Martin Sill, Almos Klekner, Andreas Unterberg, Adam M. Fontebasso, Pawel P. Liberski, Guido Reifenberger, Stefan M. Pfister, Maryam Fouladi, Andrew M. Donson, Bernhard Radlwimmer, David T.W. Jones, Sorana Morrissy, Adam Fleming, Martje Tönjes, Jacek Majewski, Jan Koster, Nicholas K. Foreman, Tim Niehues, Manuela Zucknick, Till Milde, Marcel Kool, Matthias Dürken, Christoph Plass, Dominik Sturm, Wolfram Scheurlen, Andreas von Deimling, Christof M. Kramm, Hendrik Witt, Jeremy Schwartzentruber, Steffen Albrecht, Dong Anh Khuong-Quang, Rachid Drissi, Florence M.G. Cavalli, Karine Jacob, Kenneth Aldape, Krzysztof Zakrzewski, Jörg Felsberg, Timothy E. Van Meter, Peter Hauser, Magdalena Zakrzewska, Andrey Korshunov, Carolin Konermann, Wolfgang Wick, Andreas E. Kulozik, Martin Ebinger, Christel Herold-Mende, Martin U. Schuhmann, Anders Lindroth, Damien Faury, Wolfgang Roggendorf, Elke Pfaff, Marina Ryzhova, Benedikt Wiestler, Natalia Becker, Miklós Garami, Michael C. Frühwald, Thomas Hielscher, Marietta Wolter, Camelia M. Monoranu, Christian Hartmann, Jenny Madden, Richard Volckmann, Peter van Sluis
Publikováno v:
Cancer cell, 22(4), 425-437. Cell Press
SummaryGlioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G34) of histone H3.3 in one-third of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9beb3504843665b621e584826e6a85e4
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/73170
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/73170