Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Martinus A.H. Capelle"'
Autor:
Martinus A.H. Capelle, Janik Adriaansen, Ulrike Dirmeier, Doris Salerno, Britt Raaby, Kelly Krijgsman, Lara Babich, J.P. Els van Deventer-Troost
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
The stability profile of a vaccine has important implications for storage, cold chain management and field deployment. The heterologous prime-boost Janssen Ebola vaccine regimen demonstrated an acceptable safety profile and durability of Ebola-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588e76c46f7d44a9983c424573987a16
https://pubmed.ncbi.nlm.nih.gov/29870747
https://pubmed.ncbi.nlm.nih.gov/29870747
Publikováno v:
mAbs. 5:162-170
Automation robots have recently come to the market as an alternative for manual compounding of drugs for intravenous administration. Our aim was to assess whether robotic compounding can be performed with monoclonal antibodies (mAbs) without influenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d2f1758d99d732fb77bab46ee81069
https://doi.org/10.4161/mabs.22873
https://doi.org/10.4161/mabs.22873
Publikováno v:
Journal of Drug Delivery Science and Technology. 22:427-433
Nanoparticle tracking analysis (NTA) is a relatively new technique for the size characterization of particles between 40 and 1000 nm. Recent studies have shown an increasing interest in NTA as a complementary technique in the field of pharmaceutical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11c5512a20907ef8d54374e2c1005b36
https://doi.org/10.1016/s1773-2247(12)50069-9
https://doi.org/10.1016/s1773-2247(12)50069-9
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 79:646-657
Protein aggregation, which is triggered by various factors, is still one of the most prevalent problems encountered during all stages of protein formulation development. In this publication, we present novel excipients, tryptophan-mPEGs (Trp-mPEGs) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1740431ebf5e49c3647a5006c46e33be
https://doi.org/10.1016/j.ejpb.2011.06.003
https://doi.org/10.1016/j.ejpb.2011.06.003
Publikováno v:
Vaccine. 29:7404-7413
The stability of different seasonal influenza vaccines was investigated by spectroscopy and microscopy methods before and after the following stress-conditions: (i) 2 and 4 weeks storage at 25°C, (ii) 1 day storage at 37°C and (iii) one freeze-thaw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d3b96b1091736545c35bf933981170
https://doi.org/10.1016/j.vaccine.2011.07.067
https://doi.org/10.1016/j.vaccine.2011.07.067
Autor:
Martinus A.H. Capelle, Robert Gurny, Olivier Jordan, Gia Machaidze, Tudor Arvinte, Ludmila Luca
Publikováno v:
International Journal of Pharmaceutics, Vol. 391, No 1-2 (2010) pp. 48-54
The influence of two different pH values on the physical stability of recombinant human bone morphogenetic protein-2 (rhBMP-2) in aqueous solution was evaluated in the present work. RhBMP-2 in solution at pH 4.5 or 6.5 was characterized by intrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a8ffc2c9debb89e7d333df9074120d
https://doi.org/10.1016/j.ijpharm.2010.02.015
https://doi.org/10.1016/j.ijpharm.2010.02.015
Publikováno v:
Vaccine. 23:1686-1694
MMA383 is an anti-idiotypic antibody designed as an immunogenic surrogate for the cancer specific Lewis Y antigen. Lewis Y is expressed in 70-90% of tumours of epithelial origin with limited expression in normal tissue. Five different MMA383 vaccines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f0c60f2017bf9e7b74ad7f5ca18f0f
https://doi.org/10.1016/j.vaccine.2004.09.031
https://doi.org/10.1016/j.vaccine.2004.09.031
Autor:
Martinus A.H. Capelle, Tudor Arvinte
Publikováno v:
Drug discovery today. Technologies. 5(2-3)
High-throughput screening (HTS) is used extensively in drug discovery to identify active compounds. Automated preparation and sample analysis in multiwell plates using a combination of liquid and/or powder handling stations, robotics and sensitive de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f996be48838182cebb4c8cee610533b
https://pubmed.ncbi.nlm.nih.gov/24981094
https://pubmed.ncbi.nlm.nih.gov/24981094
Publikováno v:
Pharmaceutical Sciences Encyclopedia
Bovine serum albumin (BSA) mixed with aluminum hydroxide adjuvant (Alhydrogel®) was used as a vaccine model for physicochemical studies. Methods are presented that allow studies of protein in the vaccine formulations without separation of the protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dd01149c99bb9fa2096bd1cdeb02bf7
https://doi.org/10.1002/9780470571224.pse514
https://doi.org/10.1002/9780470571224.pse514
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85(1)
Oxidation of methionine (Met) residues is one of the major chemical degradations of therapeutic proteins. This chemical degradation can occur at various stages during production and storage of a biotherapeutic drug. During the oxidation process, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb23ec8a59997db3904ed445644a9f3
https://pubmed.ncbi.nlm.nih.gov/23958317
https://pubmed.ncbi.nlm.nih.gov/23958317