Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)

Autor: Abbott Derek J, Blanchfield J Lori, Martinson David A, Russell Sean C, Taslim Najla, Curtis Alan D, Mannie Mark D

Publikováno v: BMC Immunology, Vol 12, Iss 1, p 72 (2011)

Abstract Background Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in chronic murine models

Externí odkaz: https://doaj.org/article/cf90aa1021ef42a7980739a8a6cc1177

The iron-responsive regulator irr is required for wild-type expression of the gene encoding the heme transporter BhuA in Brucella abortus 2308.

Autor: Anderson ES; Department of Microbiology and Immunology, East Carolina University School of Medicine, 600 Moye Boulevard, Greenville, NC 27834, USA., Paulley JT, Martinson DA, Gaines JM, Steele KH, Roop RM 2nd

Publikováno v: Journal of bacteriology [J Bacteriol] 2011 Oct; Vol. 193 (19), pp. 5359-64. Date of Electronic Publication: 2011 Jul 29.