Afatinib vs Placebo as Adjuvant Therapy After Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck: A Randomized Clinical Trial.

Autor: Burtness B; Department of Medicine and Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut., Haddad R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Dinis J; Instituto Português de Oncologia, Porto, Portugal., Trigo J; Department of Medical Oncology, Hospital Virgen de la Victoria, IBIMA, Malaga, Spain., Yokota T; Division of Gastrointestinal Oncology, Shizuoka Cancer Centre, Shizuoka, Japan., de Souza Viana L; Department of Medical Oncology, Hospital Marcio Cunha, Ipatinga, Brazil., Romanov I; Russian Oncological Research Centre, Moscow, Russia., Vermorken J; Department of Medical Oncology, Antwerp University Hospital, Edegem, Belgium., Bourhis J; Department of Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland., Tahara M; Department of Head and Neck Medical Oncology, National Cancer Centre Hospital East, Kashiwa, Japan., Martins Segalla JG; Department of Clinical Oncology, Hospital Amaral Carvalho, Jau, Brazil., Psyrri A; Department of Internal Medicine, National Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Vasilevskaya I; Oncology Centre of Moskovskiy, St Petersburg, Russia., Nangia CS; Comprehensive Cancer Centre, University of California at Irvine, Orange., Chaves-Conde M; Department of Oncology, Hospital Virgen del Rocio, Sevilla, Spain., Kiyota N; Department of Medical Oncology and Hematology, Kobe University Hospital Cancer Center, Kobe, Japan., Homma A; Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan., Holeckova P; Department of Oncology and Radiotherapy, Hospital Na Bulovce and 1st Medical Faculty of Charles University, Prague, Czech Republic., Del Campo JM; Department of Oncology, Vall d'Hebron University Hospital, Barcelona, Spain., Asarawala N; Shree Krishna Hospital and Medical Research Centre, Gujarat, India., Nicolau UR; Department of Clinical Oncology, AC Camargo Cancer Center, São Paulo, Brazil., Rauch D; Inselspital, University Hospital Bern, Bern, Switzerland., Even C; Department of Head and Neck Cancer, Gustave Roussy, Villejuif, France., Wang B; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut., Gibson N; Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany., Ehrnrooth E; Boehringer Ingelheim, Danmark A/S, Denmark., Harrington K; Division of Radiotherapy and Imaging, The Royal Marsden Hospital/The Institute of Cancer Research, National Institute for Health Research Biomedical Research Centre, London, United Kingdom., Cohen EEW; Department of Translational Science, Moores Cancer Centre, University of California at San Diego, La Jolla.

Publikováno v: JAMA oncology [JAMA Oncol] 2019 Aug 01; Vol. 5 (8), pp. 1170-1180.