Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martins Ikaunieks"'
Autor:
Kirill Shubin, Douglas L. Huseby, Sha Cao, Martins Ikaunieks, Kavita Yadav, Emilie Racine, Martins Katkevics, Maxime Gualtieri, Diarmaid Hughes, Tatyana Kukosha, Matthieu Sarciaux, Karin Hjort, Marine Serri, Einars Loza, Nadezhda Trufilkina, Victoria Ryabova, Edgars Suna, Lucile Pantel
A structure-activity relationship (SAR) study of NOSO-95179, a nonapeptide from the Odilorhabdin class of antibacterials, was performed by systematic variations of amino acids in positions 2 and 5 of the peptide. A series of non-proteinogenic amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc90c42ce5241631d877ea514cb999b5
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414288
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414288
Autor:
Einars Loza, Ilona Mandrika, Olga Bobileva, Ramona Petrovska, Janis Klovins, Gunars Duburs, Martins Ikaunieks
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:4314-4329
Novel series of compounds consisting of 2-amidocyclohex-1-ene carboxylate and phenyl parts which are connected by enyne (compounds 2a-f), but-1-yne (compounds 4a-j), and phenylethylene (compounds 5a-f) linkers as HCA2 full agonists were designed and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e1349627d895ce884d43cf6a463ea4
https://doi.org/10.1016/j.bmc.2017.06.028
https://doi.org/10.1016/j.bmc.2017.06.028
Autor:
Ilze Kaula, Gunars Duburs, Rasma Melita Bokaldere, Ilona Mandrika, Martins Ikaunieks, Einars Loza, Vija Gailite, Ramona Petrovska, Olga Bobileva, Janis Klovins
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3654-3669
2-(3-(Naphthalen-2-yl)propanamido)cyclohex-1-enecarboxylic acid and its 6-hydroxynaphthalen-2-yl analogue are well-known hydroxyl-carboxylic acid (HCA) receptor HCA2 agonists. A series of novel aryl derivatives of 2-amidocyclohex-1-ene carboxylic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfea011d16b4f885879b6aa5ae1a8101
https://doi.org/10.1016/j.bmc.2014.05.011
https://doi.org/10.1016/j.bmc.2014.05.011
Publikováno v:
ChemInform. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4536169976734fd84dbb5b1f3f0784e3
https://doi.org/10.1002/chin.201614154
https://doi.org/10.1002/chin.201614154
Autor:
Andrei Zaichenko, Ivars Kalvinsh, Tommy N. Johansen, Christina Trojel-Hansen, Kamille Dumong Erichsen, Karla Frydenvang, Peter Buhl Jensen, Martins Ikaunieks, Maxwell Sehested, Søren Jensby Nielsen, Mette Knak Christensen, Fredrik Björkling, Einars Loza, Birgitte Nielsen, Jette Tjørnelund
Publikováno v:
Journal of Medicinal Chemistry. 53:7140-7145
Optimization of the anticancer activity for a class of compounds built on a 1,3-dihydroindole-2-one scaffold was performed. In comparison with recently published derivatives of oxyphenisatin the new analogues exhibited an equally potent antiprolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582f0f350bb4cf8592b799329926279b
https://doi.org/10.1021/jm100763j
https://doi.org/10.1021/jm100763j
Publikováno v:
Synthesis. 2007:1325-1332
A simple and straightforward method for the introduction of some N- and 0-protecting groups into 8-bromoguanine has been developed using 2-acetylamino-8-bromo-6-oxo-9-(tetrahydrofuran-2-yl)-purine as a key intermediate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3f294909e0558ac5020ba2b495191b3
https://doi.org/10.1055/s-2007-966015
https://doi.org/10.1055/s-2007-966015
Publikováno v:
Journal of Heterocyclic Chemistry. 43:943-948
The synthesis of novel 2-amino-9-alkoxyalkylpurine derivatives with both identical and different sulfur containing substituents at positions 6 and 8 of the purine cycle has been accomplished. The thionation and alkylation of the key intermediate - 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84afb8f9f5c32aa3ed2d95b37f6646ea
https://doi.org/10.1002/jhet.5570430420
https://doi.org/10.1002/jhet.5570430420
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 61:o3452-o3454
The title compound, C18H19N5O7S, can be considered as a synthetic analogue of nucleosides. The molecule displays an anti conformation. The occurrence of N—H⋯O hydrogen bonds results in the formation of centrosymmetric dimers. The crystal packin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2af21d18c295172a4e1514fbfc5891cd
https://doi.org/10.1107/s1600536805030175
https://doi.org/10.1107/s1600536805030175
Autor:
Martins Ikaunieks, Marina Madre
Publikováno v:
ChemInform. 33
Nucleophilic halide displacement to thio group with sodium thiosulfate is a widely used method in organic chemistry particularly for the preparation of alkyl and aryl thiols. In 1989 this method was introduced into the synthesis of 6-thio- and 8thio-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85ceb35a0d9aaf986f56ac98a9bd61af
https://doi.org/10.1002/chin.200242175
https://doi.org/10.1002/chin.200242175
Publikováno v:
ChemInform. 39
New 2-amino-6-oxo-8-thioxo-9-substituted purine derivatives were prepared and assayed for the in vitro cytotoxic activity. Some products exhibited moderate activity on HT-1080 cells and rather high activity on MG-22A cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ff8cd23ea2e7bf72a997bf92225733f
https://doi.org/10.1002/chin.200812270
https://doi.org/10.1002/chin.200812270