Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Martino Maddalena"'
Autor:
Ori Hassin, Nishanth Belugali Nataraj, Michal Shreberk-Shaked, Yael Aylon, Rona Yaeger, Giulia Fontemaggi, Saptaparna Mukherjee, Martino Maddalena, Adi Avioz, Ortal Iancu, Giuseppe Mallel, Anat Gershoni, Inna Grosheva, Ester Feldmesser, Shifra Ben-Dor, Ofra Golani, Ayal Hendel, Giovanni Blandino, David Kelsen, Yosef Yarden, Moshe Oren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The differential effects of TP53 missense mutations in colorectal cancer (CRC) remain to be explored. Here the authors compare the gain of function impact of two frequent TP53 mutations in CRC and show that p53R273 mutants control a transcriptional p
Externí odkaz:
https://doaj.org/article/a119b82dad0a479ebb369694272fe374
Autor:
Freddy Khayat, Elda Cannavo, Majedh Alshmery, William R. Foster, Charly Chahwan, Martino Maddalena, Christopher Smith, Antony W. Oliver, Adam T. Watson, Antony M. Carr, Petr Cejka, Alessandro Bianchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-termin
Externí odkaz:
https://doaj.org/article/8cecf44805f740329669d3853d59d8f7
Autor:
Saptaparna Mukherjee, Martino Maddalena, YiQing Lü, Sebastien Martinez, Nishanth Belugali Nataraj, Ashish Noronha, Sansrity Sinha, Katie Teng, Victoria Cohen-Kaplan, Tamar Ziv, Sharathchandra Arandkar, Ori Hassin, Rishita Chatterjee, Anna-Chiara Pirona, Michal Shreberk-Shaked, Anat Gershoni, Yael Aylon, Zvulun Elazar, Yosef Yarden, Daniel Schramek, Moshe Oren
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Missense mutations in the p53 tumor suppressor abound in human cancer. Common (“hotspot”) mutations endow mutant p53 (mutp53) proteins with oncogenic gain of function (GOF), including enhanced cell migration and invasiveness, favoring cancer prog
Autor:
Anthony W. Oliver, Freddy Khayat, Petr Cejka, William R. Foster, Christopher Smith, Antony M. Carr, Elda Cannavo, Alessandro Bianchi, Martino Maddalena, Charly Chahwan, Adam T. Watson, Majedh Alshmery
Publikováno v:
Nature Communications, 12 (1)
Nature Communications
Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The MRN complex (MRX in Saccharomyces cerevisiae, made of Mre11, Rad50 and Nbs1/Xrs2) initiates double-stranded DNA break repair and activates the Tel1/ATM kinase in the DNA damage response. Telomeres counter both outcomes at chromosome ends, partly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525380a9dccc24ae99484cf05c3bbe93
https://hdl.handle.net/20.500.11850/491589
https://hdl.handle.net/20.500.11850/491589
Autor:
Giuseppina Lambiase, Ravid Straussman, Ron Rotkopf, Michal Lotem, Abby Kapsack, Martino Maddalena, Giuseppe Mallel, Moshe Oren, Eyal Ben-Isaac, Emma Hajaj, Nishanth Belugali Nataraj, Sharathchandra Arandkar, Michal Shreberk-Shaked, Yosef Yarden, Raya Eilam, Saptaparna Mukherjee, Bianca Pellegrino, Ori Hassin, Ofra Golani, Yoseph Addadi
Publikováno v:
Proc Natl Acad Sci U S A
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, which is refractory to all currently available treatments and bears dismal prognosis. About 70% of all PDAC cases harbor mutations in the TP53 tumor suppressor gene. Many of those are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65335fac17b9855341bea1053c40884b
https://europepmc.org/articles/PMC8201917/
https://europepmc.org/articles/PMC8201917/
Autor:
Ester Feldmesser, Michal Shreberk-Shaked, David P. Kelsen, Ori Hassin, Giulia Fontemaggi, Rona Yaeger, Saptaparna Mukherjee, Giovanni Blandino, Nishanth Belugali Nataraj, Giuseppe Mallel, Inna Grosheva, Yosef Yarden, Anat Gershon, Moshe Oren, Ofra Golani, Martino Maddalena, Yael Aylon
Colorectal cancer (CRC) is the third most common cancer worldwide. The TP53 gene is mutated in approximately 60% of all CRC cases. Sporadic CRC is characterized by high prevalence of TP53 hotspot missense mutations. In particular, over 20 percent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3a7d446540bf30c51291783adfc5525
https://doi.org/10.21203/rs.3.rs-523301/v1
https://doi.org/10.21203/rs.3.rs-523301/v1
Autor:
Petr Cejka, William R. Foster, Antony M. Carr, Charly Chahwan, Elda Cannavo, Majedh Alshmery, Adam T. Watson, Alessandro Bianchi, Anthony W. Oliver, Christopher Smith, Martino Maddalena, Freddy Khayat
The MRN complex (MRX inSaccharomyces cerevisiae) initiates the repair of DNA double-stranded breaks (DSBs) and activates the Tel1/ATM kinase, which orchestrates the DNA damage response (DDR). Telomeres prevent DDR activation at chromosome ends, partl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dedde6774609be1f51b494189e5c736
https://doi.org/10.1101/2021.03.30.437761
https://doi.org/10.1101/2021.03.30.437761
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