Physiological and Biochemical Markers of the Sex-Specific Sensitivity to Epileptogenic Factors, Delayed Consequences of Seizures and Their Response to Vitamins B1 and B6 in a Rat Model

Autor: Vasily A. Aleshin, Anastasia V. Graf, Artem V. Artiukhov, Alexandra I. Boyko, Alexander L. Ksenofontov, Maria V. Maslova, Isabel Nogués, Martino L. di Salvo, Victoria I. Bunik

Publikováno v: Pharmaceuticals, Vol 14, Iss 8, p 737 (2021)

The disturbed metabolism of vitamins B1 or B6, which are essential for neurotransmitters homeostasis, may cause seizures. Our study aims at revealing therapeutic potential of vitamins B1 and B6 by estimating the short- and long-term effects of their

Externí odkaz: https://doaj.org/article/f9a0968204bc444d8af13175f4f576c4

Isolation of a Complex Formed Between Acinetobacter baumannii HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis

Autor: Caterina Nardella, Dalila Boi, Martino L. di Salvo, Anna Barile, Jörg Stetefeld, Angela Tramonti, Roberto Contestabile

Publikováno v: Frontiers in Molecular Biosciences, Vol 6 (2019)

Plants, algae and most bacteria synthesize 5-aminolevulinic acid (ALA), the universal precursor of tetrapyrroles such as heme, chlorophyll and coenzyme B12, by a two-step transformation involving the NADPH-dependent glutamyl-tRNA reductase (HemA), wh

Externí odkaz: https://doaj.org/article/f6b62f13cb774065ae47e035283aa94c

Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy

Autor: Isabel Nogués, Victoria I. Bunik, Roberto Contestabile, Angela Tramonti, Anna Barile, Martino L. di Salvo

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific reports (Nature Publishing Group) 10 (2020). doi:10.1038/s41598-020-70598-7
info:cnr-pdr/source/autori:Barile, Anna; Nogués, Isabel; di Salvo, Martino L.; Bunik, Victoria; Contestabile, Roberto; Tramonti, Angela/titolo:Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy/doi:10.1038%2Fs41598-020-70598-7/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:10

Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5′-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60a3a8c507697eefddd9faf875efd53
http://link.springer.com/article/10.1038/s41598-020-70598-7

Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5′-Phosphate Oxidase-Dependent Epilepsy

Autor: Claudio Graziani, Victoria I. Bunik, Roberto Contestabile, Anna Barile, Martino L. di Salvo, Peter E. Clayton, Philippa B. Mills, Angela Tramonti

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International journal of molecular sciences
22 (2021). doi:10.3390/ijms222112013
info:cnr-pdr/source/autori:Barile, Anna; Mills, Philippa; Di Salvo, Martino L.; Graziani, Claudio; Bunik, Victoria; Clayton, Peter; Contestabile, Roberto; Tramonti, Angela/titolo:Characterization of novel pathogenic variants causing pyridox(am)ine 5'-phosphate oxidase-dependent epilepsy/doi:10.3390%2Fijms222112013/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
International Journal of Molecular Sciences, Vol 22, Iss 12013, p 12013 (2021)

Several variants of the enzyme pyridox(am)ine 5′-phosphate oxidase (PNPO), responsible for a rare form of vitamin B6-dependent neonatal epileptic encephalopathy known as PNPO deficiency (PNPOD), have been reported. However, only a few of them have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90430761f2ec83dba1adec7ec36fc808

Knowns and Unknowns of Vitamin B

Autor: Angela, Tramonti, Caterina, Nardella, Martino L, di Salvo, Anna, Barile, Federico, D'Alessio, Valérie, de Crécy-Lagard, Roberto, Contestabile

Publikováno v: EcoSal Plus

Vitamin B(6) is an ensemble of six interconvertible vitamers: pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), and their 5’-phosphate derivatives PNP, PMP, and PLP. Pyridoxal 5’-phosphate is a coenzyme in a variety of enzyme reactions concerni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bf686e25a04f2347108a684d413672d
https://pubmed.ncbi.nlm.nih.gov/33787481