Výsledky vyhledávání - "Martini, Johannes"

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Cooperativity, Absolute Interaction, and Algebraic Optimization

Autor: Kaihnsa, Nidhi, Ren, Yue, Din, Mohab Safey El, Martini, Johannes W. R.

We consider a measure of cooperativity based on the minimal absolute interaction required to generate an observed titration behavior. We describe the corresponding algebraic optimization problem and show how it can be solved using the nonlinear algeb

Externí odkaz: http://arxiv.org/abs/1906.10006

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Lost in translation: On the impact of data coding on penalized regression with interactions

Autor: Martini, Johannes W R, Rosales, Francisco, Ha, Ngoc-Thuy, Kneib, Thomas, Heise, Johannes, Wimmer, Valentin

Publikováno v: G3 (2019) https://doi.org/10.1534/g3.118.200961

Penalized regression approaches are standard tools in quantitative genetics. It is known that the fit of an \emph{ordinary least squares} (OLS) regression is independent of certain transformations of the coding of the predictor variables, and that th

Externí odkaz: http://arxiv.org/abs/1806.03729

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Decoupled molecules with binding polynomials of bidegree (n,2)

Autor: Ren, Yue, Martini, Johannes W. R., Torres, Jacinta

Publikováno v: Journal of Mathematical Biology (2019) https://doi.org/10.1007/s00285-018-1295-x

We present a result on the number of decoupled molecules for systems binding two different types of ligands. In the case of $n$ and $2$ binding sites respectively, we show that, generically, there are $2(n!)^{2}$ decoupled molecules with the same bin

Externí odkaz: http://arxiv.org/abs/1711.06865

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