Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel.

Autor: Van Theemsche KM; Department of Basic and Applied Medical Sciences, Faculty of Medicine, Ghent University, 9000 Ghent, Belgium; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Frans L; Department of Basic and Applied Medical Sciences, Faculty of Medicine, Ghent University, 9000 Ghent, Belgium., Van de Sande DV; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Martinez-Morales E; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Snyders DJ; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Labro AJ; Department of Basic and Applied Medical Sciences, Faculty of Medicine, Ghent University, 9000 Ghent, Belgium. Electronic address: alain.labro@ugent.be.

Publikováno v: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2024 Nov-Dec; Vol. 130, pp. 107566. Date of Electronic Publication: 2024 Sep 30.

The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels.

Autor: Coonen L; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Martinez-Morales E; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Van De Sande DV; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Snyders DJ; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Cortes DM; Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA., Cuello LG; Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA., Labro AJ; Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium.; Department of Basic and Applied Medical Sciences, Faculty of Medicine, Ghent University, 9000 Ghent, Belgium.

Publikováno v: Science advances [Sci Adv] 2022 Sep 16; Vol. 8 (37), pp. eabn1731. Date of Electronic Publication: 2022 Sep 16.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.

Autor: Liu, Zhipei^1,2 (AUTHOR), Wang, Feng^1,3 (AUTHOR), Yuan, Hui^1,3 (AUTHOR), Tian, Fuyun^1,2 (AUTHOR), Yang, Chuanyan^1,2,4 (AUTHOR), Hu, Fei^1,2 (AUTHOR), Liu, Yiyao¹ (AUTHOR), Tang, Meiqin^1,5 (AUTHOR), Ping, Meixuan^1,2,6 (AUTHOR), Kang, Chunlan^1,5 (AUTHOR), Luo, Ting^1,7 (AUTHOR), Yang, Guimei^1,3 (AUTHOR), Hu, Mei^1,8 (AUTHOR), Gao, Zhaobing^1,2,3,6 (AUTHOR) zbgao@simm.ac.cn, Li, Ping^1,2,3,6 (AUTHOR) lipingt@simm.ac.cn

Publikováno v: BMC Biology. 2/5/2024, Vol. 22 Issue 1, p1-14. 14p.

A residue W756 in the P-loop segment of the sodium channel is critical for primaquine binding.

Autor: Salinas-Stefanon EM; Instituto de Fisiología, B.Universidad Autónoma de Puebla, Mexico. salinas@siu.buap.mx, Martinez-Morales E, Scior TF, Millan-PerezPeña L

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2011 Aug 01; Vol. 663 (1-3), pp. 1-8. Date of Electronic Publication: 2011 Apr 27.