Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Martinez-Guimera A"'
Autor:
R.-L. Scanlan, L. Pease, H. O’Keefe, A. Martinez-Guimera, L. Rasmussen, J. Wordsworth, D. Shanley
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
Cellular senescence is a diverse phenotype characterised by permanent cell cycle arrest and an associated secretory phenotype (SASP) which includes inflammatory cytokines. Typically, senescent cells are removed by the immune system, but this process
Externí odkaz:
https://doaj.org/article/9220d0153a6440968a8ba4f138aad4be
Autor:
Scanlan, R.-L., Pease, L., O'Keefe, H., Martinez-Guimera, A., Rasmussen, L., Wordsworth, J., Shanley, D.
Publikováno v:
Frontiers in Aging Neuroscience; 2024, p1-26, 26p
Autor:
Martinez Guimera, Alvaro, Welsh, Ciaran M., Proctor, Carole J., McArdle, Anne, Shanley, Daryl P.
Publikováno v:
In Mechanisms of Ageing and Development January 2018 169:53-62
Autor:
Alvaro Martinez Guimera, Peter Clark, James Wordsworth, Sharath Anugula, Lene Juel Rasmussen, Daryl P. Shanley
Publikováno v:
Guimera, A M, Clark, P, Wordsworth, J, Anugula, S, Rasmussen, L J & Shanley, D P 2022, ' Systems modelling predicts chronic inflammation and genomic instability prevent effective mitochondrial regulation during biological ageing ', Experimental Gerontology, vol. 166, 111889 . https://doi.org/10.1016/j.exger.2022.111889
The regulation of mitochondrial turnover under conditions of stress occurs partly through the AMPK-NAD+-PGC1α-SIRT1 signalling pathway. This pathway can be affected by both genomic instability and chronic inflammation since these will result in an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297646c9d11ab590b86cff0a0bfef1b9
https://pubmed.ncbi.nlm.nih.gov/35811018
https://pubmed.ncbi.nlm.nih.gov/35811018
Publikováno v:
Free Radical Biology and Medicine. 132:11-18
The decline in the musculoskeletal system with age is driven at the cellular level by random molecular damage. Cells possess mechanisms to repair or remove damage and many of the pathways involved in this response are regulated by redox signals. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedeb613d4cdae3384d01b79f828e146
https://doi.org/10.1016/j.freeradbiomed.2018.09.013
https://doi.org/10.1016/j.freeradbiomed.2018.09.013
Biological ageing is a process that encompasses observations often too heterogeneous to draw coherent conceptual frameworks that may shed light into the generality of the underlying gradual loss of function. Whilst the concept of stochastic damage is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295fb15efe234e18f9b906df8973809a
https://doi.org/10.1101/753566
https://doi.org/10.1101/753566
Autor:
Martinez Guimera, Alvaro
Ageing and disease can be understood in terms of a loss in biological homeostasis. This will often manifest as a constitutive elevation in the basal levels of biological entities. Examples include chronic inflammation, hormonal imbalances and oxidati
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.765376
Autor:
Martinez Guimera, Alvaro, Welsh, Ciaran, Dalle Pezze, Piero, Fullard, Nicola, Nelson, Glyn, Roger, Mathilde F., Przyborski, Stefan A., Shanley, Daryl P.
Publikováno v:
Essays in biochemistry, 2017, Vol.61(3), pp.369-377 [Peer Reviewed Journal]
Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______328::95484d388d9dcdf745d83fa6d8b173bd
http://dro.dur.ac.uk/22408/1/22408.pdf
http://dro.dur.ac.uk/22408/1/22408.pdf
Autor:
Alvaro, Martinez Guimera, Ciaran, Welsh, Piero, Dalle Pezze, Nicola, Fullard, Glyn, Nelson, Mathilde F, Roger, Stefan A, Przyborski, Daryl P, Shanley
Publikováno v:
Essays in Biochemistry
Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::002f5e87668039224af7084a9e0f4a63
https://pubmed.ncbi.nlm.nih.gov/28698310
https://pubmed.ncbi.nlm.nih.gov/28698310
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