O6 Single doses as low as 0.5 mg of the novel NRTTI MK-8591 suppress HIV for at least 7 days

Autor: Inge De Lepeleire, Randolph P. Matthews, Dirk Schürmann, Deanne J. Rudd, Vanessa Levine, Sabrina Fox-Bosetti, Sandra Zhang, Martine Robberechts, Andreas Hüser, DariaJ Hazuda, JayA Grobler, Aubrey Stoch, Marian Iwamoto

Publikováno v: Journal of Virus Eradication, Vol 3, Iss , Pp 2- (2017)

Externí odkaz: https://doaj.org/article/6c4df87c6b224d3eaa78329f23363c77

Single Oral Doses of MK-8507, a Novel Non-Nucleoside Reverse Transcriptase Inhibitor, Suppress HIV-1 RNA for a Week

Autor: Martin Daumer, Wendy Ankrom, Deanne Jackson Rudd, Yang Liu, Dirk Schürmann, Jörg Hofmann, Marian Iwamoto, Inge De Lepeleire, Christian Keicher, Evan J. Friedman, Martine Robberechts, Andrea K. Schaeffer, S. Aubrey Stoch, Jay A. Grobler, Bhargava Kandala, Saijuan Zhang

Publikováno v: Journal of Acquired Immune Deficiency Syndromes (1999)

Background MK-8507 is a novel HIV-1 non-nucleoside reverse transcriptase inhibitor being developed for treatment of HIV-1 infection. MK-8507 has high antiviral potency in vitro and pharmacokinetic (PK) properties that support once-weekly dosing. Sett

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d822287e947e4275e511e6e9962a10
http://europepmc.org/articles/PMC8740605

IL-17-high asthma with features of a psoriasis immunophenotype

Autor: Jörgen Östling, Marleen van Geest, James P.R. Schofield, Zala Jevnikar, Susan Wilson, Jonathan Ward, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Sven-Erik Dahlen, Stephen J. Fowler, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Ana R. Sousa, Yike Guo, Ian M. Adcock, Peter Howarth, Kian Fan Chung, Jeanette Bigler, Peter J. Sterk, Paul J. Skipp, Ratko Djukanović, Outi Vaarala, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, K.F. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powell, G. Praticò, M. Puig N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Antonios Aliprantis, David Allen, Kjell Alving, P. Badorrek, David Balgoma, S. Ballereau, Clair Barber, Manohara Kanangana Batuwitage, A. Bautmans, A. Bedding, A.F. Behndig, Jorge Beleta, A. Berglind, A. Berton, Grazyna Bochenek, Armin Braun, D. Campagna, Leon Carayannopoulos, C. Casaulta, Romanas Chaleckis, B. Dahlén, imothy Davison, Jorge De Alba, Inge De Lepeleire, Tamara Dekker, Ingrid Delin, P. Dennison, Annemiek Dijkhuis, Paul Dodson, Aleksandra Draper, K. Dyson, Jessica Edwards, L. El Hadjam, Rosalia Emma, Magnus Ericsson, C. Faulenbach, Breda Flood, G. Galffy, Hector Gallart, D. Garissi, J. Gent, M. Gerhardsson de Verdier, D. Gibeon, Cristina Gomez, Kerry Gove, Neil Gozzard, E. Guillmant-Farry, E. Henriksson, Lorraine Hewitt, U. Hoda, Richard Hu, Sile Hu, X. Hu, E. Jeyasingham, K. Johnson, N. Jullian, Juliette Kamphuis, Erika J. Kennington, Dyson Kerry, G. Kerry, M. Klüglich, Hugo Knobel, Johan Kolmert, J.R. Konradsen, Maxim Kots, Kosmas Kretsos, L. Krueger, Scott Kuo, Maciej Kupczyk, Bart Lambrecht, A.-S. Lantz, Christopher Larminie, L.X. Larsson, P. Latzin, N. Lazarinis, N. Lemonnier, Saeeda Lone-Latif, L.A. Lowe, Alexander Manta, Lisa Marouzet, Jane Martin, Caroline Mathon, L. McEvoy, Sally Meah, A. Menzies-Gow, Leanne Metcalf, Maria Mikus, Philip Monk, Shama Naz, K. Nething, Ben Nicholas, U. Nihlén, Peter Nilsson, R. Niven, B. Nordlund, S. Nsubuga, Antonio Pacino, Susanna Palkonen, J. Pellet, Giorgio Pennazza, Anne Petrén, Sandy Pink, C. Pison, Anthony Postle, Malayka Rahman-Amin, Lara Ravanetti, Emma Ray, Stacey Reinke, Leanne Reynolds, K. Riemann, Martine Robberechts, J.P. Rocha, C. Rossios, Kirsty Russell, Michael Rutgers, G. Santini, Marco Santoninco, M. Saqi, Corinna Schoelch, S. Scott, N. Sehgal, Marcus Sjödin, Barbara Smids, Caroline Smith, Jessica Smith, Katherine M. Smith, P. Söderman, A. Sogbessan, F. Spycher, Doroteya Staykova, S. Stephan, J. Stokholm, K. Strandberg, M. Sunther, M. Szentkereszty, L. Tamasi, K. Tariq, John-Olof Thörngren, Jonathan Thorsen, S. Valente, Marianne van de Pol, C.M. van Drunen, Jonathan Van Eyll, Jenny Versnel, Anton Vink, C. von Garnier, A. Vyas, Frans Wald, Samantha Walker, Kristiane Wetzel, Coen Wiegman, Siân Williams, Xian Yang, Elizabeth Yeyasingham, W. Yu Amgen, W. Zetterquist, Z. Zolkipli, A.H. Zwinderman

Publikováno v: Journal of Allergy and Clinical Immunology, 144(5), 1198-1213. Mosby Inc.
U-BIOPRED Study Group 2019, ' IL-17-high asthma with features of a psoriasis immunophenotype ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2019.03.027
Journal of allergy and clinical immunology, 144(5), 1198-1213. Mosby Inc.
Östling, J R, van Geest, M, U-BIOPRED Study Group, Schofield, J P R, Jevnikar, Z, Wilson, S, Ward, J, Lutter, R, Shaw, D E, Bakke, P S, Caruso, M, Dahlen, S-E, Fowler, S J, Horváth, I, Krug, N, Montuschi, P, Sanak, M, Sandström, T, Sun, K, Pandis, I, Auffray, C, Sousa, A R, Guo, Y, Adcock, I M, Howarth, P, Chung, K F, Bigler, J, Sterk, P J, Skipp, P J, Djukanović, R & Vaarala, O 2019, ' IL-17–high asthma with features of a psoriasis immunophenotype ', Journal of Allergy and Clinical Immunology, vol. 144, no. 5, pp. 1198-1213 . https://doi.org/10.1016/j.jaci.2019.03.027

Background The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective We sought to undertake a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924ef083d27395d6795993c461f0cec8
https://publica.fraunhofer.de/handle/publica/259279

Rhinovirus challenge in asthmatics and healthy volunteers to evaluate the safety and appropriate dose of a GMP human rhinovirus 16 preparation for challenge studies in mild-moderate asthmatics taking ICS

Autor: Norbert Krug, Jens M. Hohlfeld, Antonios Aliprantis, Leonidas Carayannopoulos, An Bautmans, Martine Robberechts, Inge De Lepeleire, Holger Ziehr, Dave Singh, Zuzana Diamant, Shan Yang, Neil Fitch, Bob Thornton, Peter J. Sterk, Rene Lutter And The U-Biopred Study Group

Introduction: Rhinovirus (RV) infection is the most important trigger for asthma exacerbation. However, no GMP grade RV preparation and established protocols are available for human RV challenge studies. Aim: To establish safety and tolerability of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72029b71c39a433e8205476800074265
https://publica.fraunhofer.de/handle/publica/259306

Antiviral Activity, Safety, and Tolerability of Multiple Ascending Doses of Elbasvir or Grazoprevir in Participants Infected With Hepatitis C Virus Genotype-1 or -3

Autor: Robert B. Nachbar, John A. Wagner, Deborah Panebianco, Valentin S. Moiseev, Zhanna Kobalava, Edward Gane, Christina Reitmann, Sorin Visan, Kristien Van Dyck, Frank J. Dutko, Martine Robberechts, Inge De Lepeleire, Wendy W. Yeh, Andreas Hüser, Zifang Guo, Christian Schwabe, Joan R. Butterton, Edward O'Mara, Markus Uhle, Iain P. Fraser, Xiaobi Huang, Nelea Ghicavii, Patricia Jumes, Serghei Popa, Amelia S. Petry, Frank Wagner

Publikováno v: Clinical Therapeutics. 40:704-718.e6

Purpose Elbasvir (MK-8742) and grazoprevir (MK-5172; Merck & Co, Inc, Kenilworth, New Jersey) are hepatitis C virus (HCV)-specific inhibitors of the nonstructural protein 5A phosphoprotein and the nonstructural protein 3/4A protease, respectively. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859e887a63702d1bb18e52d8097ed5ca
https://doi.org/10.1016/j.clinthera.2018.03.002