Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Martine Polhuijs"'
Autor:
Kees Pleijsier, Marcel J. van der Schans, Jan P. Langenberg, Hendrik P. Benschop, Corry Van Dijk, Carla E. A. M. Degenhardt, Martine Polhuijs
Publikováno v:
Archives of Toxicology. 78:508-524
The utility was explored of a new approach to detect retrospectively exposure to nerve agents by means of conversion of the inhibitor moiety bound to the active site of the enzyme BuChE in plasma with fluoride ions into a phosphofluoridate which is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab2eedab5eb6c902b7334264e98ce3b
https://doi.org/10.1007/s00204-004-0568-x
https://doi.org/10.1007/s00204-004-0568-x
Autor:
Albert G. Hulst, Daan Noort, Martine Polhuijs, Dominique H. J. M. Platenburg, Hendrik P. Benschop
Publikováno v:
Archives of Toxicology. 72:671-675
A convenient and rapid micro-anion exchange liquid chromatography (LC) tandem electrospray mass spectrometry (MS) procedure was developed for quantitative analysis in serum of O-isopropyl methylphosphonic acid (IMPA), the hydrolysis product of the ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052d5cd9a4fd019fb14cab9b303a1aa3
https://doi.org/10.1007/s002040050559
https://doi.org/10.1007/s002040050559
Publikováno v:
Toxicology and Applied Pharmacology. 146:156-161
With regard to detection of exposure to anticholinesterase, the presently used methods have the disadvantage that they cannot detect either low-level exposures with certainty or the structure of the agent and the extent of poisoning. In principle, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4694f55e5fe4102657f456ce56ad19b
https://doi.org/10.1006/taap.1997.8243
https://doi.org/10.1006/taap.1997.8243
Publikováno v:
Chirality. 4:407-414
Glutathione (GSH) conjugation of the chiral compound 2-bromo-3-phenylpropionic acid (BPP) was studied in vitro and in the rat in vivo. GSH conjugation of BPP, catalyzed by a mixture of glutathione-S-transferases (GST's) from rat liver cytosol in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6479943a2f3076724222b744604ff1d6
https://doi.org/10.1002/chir.530040702
https://doi.org/10.1002/chir.530040702
Autor:
Albert G. Hulst, H. P. Benschop, Leo P. A. De Jong, Martine Polhuijs, Jan P. Langenberg, Daan Noort
Publikováno v:
NBC Risks Current Capabilities and Future Perspectives for Protection ISBN: 9780792358039
The terrorist attacks with nerve agents in Japan as well as the ongoing debate on a possible relationship between the so-called Gulf War Syndrome and accidental exposure to traces of nerve agents have made clear that improved methods for detection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ef8296cb45a72cf01bc81726be9d59d
https://doi.org/10.1007/978-94-011-4641-8_40
https://doi.org/10.1007/978-94-011-4641-8_40
Publikováno v:
Structure and Function of Cholinesterases and Related Proteins ISBN: 9781489915429
Chemical warfare agents are rapidly proliferating over the world. It is well documented that Iraq used sulfur mustard in the war with Iran and nerve agents against the Kurdish opposition. Members of the AUM Shinriyko sect were the first to use nerve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b6fc7d857008bf5ed40b86e8902fe6e
https://doi.org/10.1007/978-1-4899-1540-5_79
https://doi.org/10.1007/978-1-4899-1540-5_79
Publikováno v:
Biochemical pharmacology. 44(7)
Glutathione (GSH) conjugation of the separate enantiomers of five 2-bromocarboxylic acids and some of their urea derivatives by rat liver GSH transferases (GSTs) was studied. The liver cytosolic fraction conjugated all compounds, except for (R)-2-bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2b49aac00b2657aac924dd075e8a3d
https://pubmed.ncbi.nlm.nih.gov/1417949
https://pubmed.ncbi.nlm.nih.gov/1417949
Publikováno v:
Biochemical Pharmacology. 38:3957-3962
The glutathione (GSH) conjugation of (R)-and (S)-alpha-bromoisovaleric acid (BI) in the rat in vivo, and its stereoselectivity, have been characterized. After administration of racemic [1-14C]BI two radioactive metabolites were found in bile: only on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591284da30e910d2c63683cc275f448d
https://doi.org/10.1016/0006-2952(89)90674-6
https://doi.org/10.1016/0006-2952(89)90674-6