Differential regulation of Foxo3a target genes in erythropoiesis

Autor: Peter Steinlein, Andrea Kolbus, Tak W. Mak, Kazuo Yamamoto, Marieke von Lindern, Hartmut Beug, Roel G. W. Verhaak, Thamar B. van Dijk, Martine Parren-van Amelsvoort, Bob Löwenberg, Walbert Bakker

Publikováno v: Molecular and Cellular Biology, 27(10), 3839-3854. American Society for Microbiology
Molecular and cellular biology, 27(10), 3839-3854. American Society for Microbiology

The cooperation of stem cell factor (SCF) and erythropoietin (Epo) is required to induce renewal divisions in erythroid progenitors, whereas differentiation to mature erythrocytes requires the presence of Epo only. Epo and SCF activate common signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b61f38de700136f7a70e21aa7fd94c2
https://doi.org/10.1128/mcb.01662-06

Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis

Autor: Eva Maria Deiner, Marieke von Lindern, Hartmut Beug, Michael J. Hayman, Martine Parren-van Amelsvoort, Helmut Dolznig, Ernst W. Müllner

Publikováno v: Oncogene, 20, 3651-3664. Nature Publishing Group
Oncogene, 20(28), 3651-3664. Nature Publishing Group

Primary erythroid progenitors can be expanded by the synergistic action of erythropoietin (Epo), stem cell factor (SCF) and glucocorticoids. While Epo is required for erythropoiesis in general, glucocorticoids and SCF mainly contribute to stress eryt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b43f4146255af11a2c7706e905d301
https://doi.org/10.1038/sj.onc.1204494

Protein kinase C alpha controls erythropoietin receptor signaling

Autor: Hartmut Beug, Thamar B. van Dijk, Sjenet E. van Emst-de Vries, Emile van den Akker, Martine Parren-van Amelsvoort, Peter H.G.M. Willems, Marieke von Lindern, Bob Löwenberg, E M Deiner

Publikováno v: Journal of Biological Chemistry, 275(44), 34719-34727. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 275, 34719-34727
Journal of biological chemistry, 275(44), 34719-34727. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 275, pp. 34719-34727

Protein kinase C (PKC) is implied in the activation of multiple targets of erythropoietin (Epo) signaling, but its exact role in Epo receptor (EpoR) signal transduction and in the regulation of erythroid proliferation and differentiation remained elu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3441ad83a909266110695519a1027b53
https://doi.org/10.1074/jbc.m007042200

Erythropoietin-Induced Activation of STAT5 Is Impaired in the Myelodysplastic Syndrome

Autor: Lies H. Hoefsloot, Lianne C.A.M. Broeders, Ivo P. Touw, Kirsten van Lom, Dorien van der Plas, Bob Löwenberg, Hans Hoogerbrugge, Martine Parren-van Amelsvoort

Publikováno v: Blood, 89(5), 1690-1700. American Society of Hematology

Patients with myelodysplastic syndrome (MDS) have ineffective in vivo and in vitro erythropoiesis, characterized by an impaired response to erythropoietin (Epo). We examined proliferation and maturation of MDS marrow cells in response to Epo in more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65bebd1b23f423b934fbf2d18e6dffe
https://pure.eur.nl/en/publications/56fea55c-faad-4cc3-a556-cdb1b108678c