The role of thymic accessory cells in cytokine production and in the intra-thymic T cell differentiation pathway

Autor: Martine Papiernik

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 82, Pp 23-28 (1987)

Intrathymic T lymphocyte differentiation proceeds from complex interactions between prothymocytes of bone marrow origin and cells of the thymic stroma, epithelial cells and "acessory" cells (macrophages and/or interdigitating cells). The present pape

Externí odkaz: https://doaj.org/article/9a4f318582b746328f3ca7d8ce7e2334

Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation

Autor: Anne Goubier, Bertrand Dubois, Ludivine Chapat, Martine Papiernik, Jean-François Nicolas, Dominique Kaiserlian

Publikováno v: Blood. 102:3295-3301

To elucidate the role of CD4+CD25+ regulatory T cells in oral tolerance, we used the model of contact hypersensitivity (CHS) to 2,4-dinitrofluorobenzene (DNFB), which is mediated by CD8+ Tc1 effector cells independently of CD4+ T-cell help. Conversel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7568bd7e6dac2a5668b1e16acb4591
https://doi.org/10.1182/blood-2003-03-0727

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

Autor: Martine Papiernik, Afonso R. M. Almeida, Antonio A. Freitas, Nicolas Legrand

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2002, 169 (9), pp.4850-60. ⟨10.4049/jimmunol.169.9.4850⟩
Journal of Immunology, 2002, 169 (9), pp.4850-60. ⟨10.4049/jimmunol.169.9.4850⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2002, 169 (9), pp.4850-60
Journal of immunology (Baltimore, Md., 169(9), 4850-4860. American Association of Immunologists

We show that the lymphoid hyperplasia observed in IL-2Rα- and IL-2-deficient mice is due to the lack of a population of regulatory cells essential for CD4 T cell homeostasis. In chimeras reconstituted with bone marrow cells from IL-2Rα-deficient do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5dd88a962005b9b0c7e534bc0c70aa
https://doi.org/10.4049/jimmunol.169.9.4850

Natural regulatory CD4 T cells expressing CD25

Autor: Martine Papiernik, Alice Banz

Publikováno v: Microbes and Infection. 3:937-945

In normal mice, a subpopulation of CD4 T cells constitutively express CD25. These cells behave as regulatory T cells in autoimmune and inflammatory reactions, in tolerance to superantigens, and in peripheral T-cell homeostasis. They are unable to pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed72e3127942dc465a8ca8d1d5593d8b
https://doi.org/10.1016/s1286-4579(01)01455-1

IL-4-producing NK T cells are biased towards IFN-γ production by IL-12. Influence of the microenvironment on the functional capacities of NK T cells

Autor: Maria Leite-de-Moraes, Corinne Garcia, Martine Papiernik, Michel Dy, Géraldine Moreau, François Machavoine, Anne Arnould

Publikováno v: European Journal of Immunology
European Journal of Immunology, 1998, 28 (5), pp.1507-1515. ⟨10.1002/(SICI)1521-4141(199805)28:053.0.CO;2-F⟩

International audience; NK T cells are an unusual T lymphocyte subset capable of promptly producing several cytokines after stimulation, in particular IL-4, thus suggesting their influence in Th2 lineage commitment. In this study we demonstrate that,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24465dc14fc3eb998c10ab99e1b8257
https://doi.org/10.1002/(sici)1521-4141(199805)28:05<1507::aid-immu1507>3.0.co