Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Martine L M Lamfers"'
Autor:
Ya Gao, Maurice de Wit, Eduard A Struys, Herma C Z van der Linde, Gajja S Salomons, Martine L M Lamfers, Rob Willemsen, Peter A E Sillevis Smitt, Pim J French
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199737 (2018)
INTRODUCTION:The gene encoding isocitrate dehydrogenase 1 (IDH1) is frequently mutated in several tumor types including gliomas. The most prevalent mutation in gliomas is a missense mutation leading to a substitution of arginine with histidine at the
Externí odkaz:
https://doaj.org/article/0fc8f271716f461b9746cc9cb4fc90fb
Autor:
Lotte M E Berghauser Pont, Anne Kleijn, Jenneke J Kloezeman, Wouter van den Bossche, Johanna K Kaufmann, Jeroen de Vrij, Sieger Leenstra, Clemens M F Dirven, Martine L M Lamfers
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127058 (2015)
A phase I/II trial for glioblastoma with the oncolytic adenovirus Delta24-RGD was recently completed. Delta24-RGD conditionally replicates in cells with a disrupted retinoblastoma-pathway and enters cells via αvβ3/5 integrins. Glioblastomas are dif
Externí odkaz:
https://doaj.org/article/23702382f25b4061a5448aa9022693d4
Autor:
Sander Idema, Viola Caretti, Martine L M Lamfers, Victor W van Beusechem, David P Noske, W Peter Vandertop, Clemens M F Dirven
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24396 (2011)
Convection-enhanced delivery (CED) of adenoviruses offers the potential of widespread virus distribution in the brain. In CED, the volume of distribution (Vd) should be related to the volume of infusion (Vi) and not to dose, but when using adenovirus
Externí odkaz:
https://doaj.org/article/90ce4e38e8d245779072901649e2b272
Autor:
Federica Fabro, Nynke M. Kannegieter, Erik L. de Graaf, Karla Queiroz, Martine L. M. Lamfers, Anna Ressa, Sieger Leenstra
Publikováno v:
Frontiers in Oncology, 12:1012236. Frontiers Media S.A.
Glioblastoma is the deadliest brain cancer. One of the main reasons for poor outcome resides in therapy resistance, which adds additional challenges in finding an effective treatment. Small protein kinase inhibitors are molecules that have become wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9d04adb2ecad1a91fd48e339dc89ef
https://pubmed.ncbi.nlm.nih.gov/36408180
https://pubmed.ncbi.nlm.nih.gov/36408180
Publikováno v:
Cancers. 14(15)
Glioblastoma (GBM) remains one of the most difficult tumors to treat. The mean overall survival rate of 15 months and the 5-year survival rate of 5% have not significantly changed for almost 2 decades. Despite progress in understanding the pathophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3333687e49c19f8d2bee59bec7bf9745
https://pubmed.ncbi.nlm.nih.gov/35954371
https://pubmed.ncbi.nlm.nih.gov/35954371
Autor:
Ioannis Ntafoulis, Anne Kleijn, Cassandra Posthoorn-Verheul, Stijn L W Koolen, Trisha Kers, Chelsea W J den Hollander, Jie Ju, Yunlei Li, Andrew P Stubbs, Clemens M F Dirven, Sieger Leenstra, Martine L M Lamfers
Publikováno v:
Neuro-Oncology. 24:vii104-vii105
BACKGROUND Major obstacles that have impeded the development of effective new therapies for GBM include inter- and intratumoral heterogeneity, the blood-brain-barrier and use of sub-optimal cell line-based preclinical models. Taking these hurdles int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::762ff97f91b6b088e2ef7b1c631932dd
https://doi.org/10.1093/neuonc/noac209.392
https://doi.org/10.1093/neuonc/noac209.392
Autor:
Lennard J. M. Dekker, Cassandra Verheul, Nicky Wensveen, William Leenders, Martine L. M. Lamfers, Sieger Leenstra, Theo M. Luider
Publikováno v:
ACS Omega, 7, 4, pp. 3568-3578
ACS Omega, 7, 3568-3578
ACS Omega, Vol 7, Iss 4, Pp 3568-3578 (2022)
ACS Omega, 7(4), 3568-3578. American Chemical Society
ACS Omega
ACS Omega, 7, 3568-3578
ACS Omega, Vol 7, Iss 4, Pp 3568-3578 (2022)
ACS Omega, 7(4), 3568-3578. American Chemical Society
ACS Omega
The R132H mutation in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) is the most important prognostic factor for the survival of glioma patients. Subsequent studies led to the discovery of a panel of enzymes mainly involved in glutamate anapl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a0f96b868eb751df7311918f27aecc
https://repository.ubn.ru.nl/handle/2066/248779
https://repository.ubn.ru.nl/handle/2066/248779
Autor:
Nastaran Barin, Hayri E. Balcioglu, Iris de Heer, Maurice de Wit, Martine L. M. Lamfers, Martin E. van Royen, Pim J. French, Angelo Accardo
Publikováno v:
Small. 18:2270264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::851bdf9d807f8f6f23e76d952d20900a
https://doi.org/10.1002/smll.202270264
https://doi.org/10.1002/smll.202270264
Autor:
Remi Weber, Flavio Vasella, Artsiom Klimko, Manuela Silginer, Martine L M Lamfers, Luca Regli, Gerald Schwank, Michael Weller
Publikováno v:
Neuro-Oncology. 24:vii217-vii217
Gliomas are the most frequent malignant primary brain tumors and continue to lack curative therapies. To aid the development of novel therapeutic approaches, a better understanding of glioma-specific molecular patterns is essential. We therefore inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86442f4a8f46ea5b0b3fb8451c92d38f
https://doi.org/10.1093/neuonc/noac209.835
https://doi.org/10.1093/neuonc/noac209.835
Autor:
Eftychia Stavrakaki, Wouter B L van den Bossche, Rutger Balvers, Lisette B Vogelezang, Cristina Teodosio, Dana A M Mustafa, Willem de Koning, Andrew P Stubbs, William F Goins, Hiroshi Nakashima, E Antonio Chiocca, Jacques J M van Dongen, Clemens M F Dirven, Martine L M Lamfers
Publikováno v:
Neuro-Oncology. 24:vii221-vii221
BACKGROUND The dismal prognosis of glioblastoma (GBM) patients, with a median survival of less than 15 months despite maximal therapy urgently warrants new therapeutic approaches. Clinical trials employing oncolytic viruses (OVs) have shown encouragi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eb92db9ffa4171ee477c313d4e87242
https://doi.org/10.1093/neuonc/noac209.852
https://doi.org/10.1093/neuonc/noac209.852