Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Martine Keenan"'
Autor:
Martine Keenan, Eric Chatelain
Publikováno v:
Neglected Tropical Diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::352468cba8ae4f9ffdf66943bc3d4e0f
https://doi.org/10.1002/9783527808656.ch4
https://doi.org/10.1002/9783527808656.ch4
Autor:
Patrick D. O'Connor, William A. Denny, John M. Kelly, Karen L. White, Vicky M. Avery, Melissa Sykes, Amanda F. Francisco, Scott Cornwall, Andrew J. Marshall, Jennifer Riley, Bilal Zulfiqar, Susan A. Charman, Catherine J. Perez, Kevin D. Read, Eric Chatelain, Andrew M. Thompson, R.C. Andrew Thompson, Martine Keenan
Phenotypic screening of a 900 compound library of antitubercular nitroimidazole derivatives related to pretomanid against the protozoan parasite Trypanosoma cruzi (the causative agent for Chagas disease) identified several structurally diverse hits w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f4d7d9298b453cdb9602cabb875e1e
Autor:
Martine Keenan, Eileen Ryan, Scott Cornwall, Andrea Khong, Jason H. Chaplin, Wayne M. Best, Karen L. White, R.C. Andrew Thompson, Catherine J. Perez, Ivan Scandale, Susan A. Charman, Michael J. Abbott, Paul W. Alexander, Francis C. K. Chiu, David M. Shackleford, Michael Campbell, Maria Koltun, Eric Chatelain, Adriana Botero, Julia Morizzi, Thomas W. von Geldern
Publikováno v:
Journal of Medicinal Chemistry
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is an increasing threat to global health. Available medicines were introduced over 40 years ago, have undesirable side effects, and give equivocal results of cure in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38832ff07aa1233c73b2095f1457b219
https://doi.org/10.1021/jm401610c
https://doi.org/10.1021/jm401610c
Autor:
Eric Chatelain, Tatiana Y. Hargrove, Martine Keenan, Michael R. Waterman, Paul W. Alexander, Galina I. Lepesheva, Susan A. Charman, Jason H. Chaplin, Catherine J. Perez, Zdzislaw Wawrzak
Publikováno v:
Journal of Biological Chemistry. 288:31602-31615
Chagas disease, caused by the eukaryotic (protozoan) parasite Trypanosoma cruzi, is an alarming emerging global health problem with no clinical drugs available to treat the chronic stage. Azole inhibitors of sterol 14α-demethylase (CYP51) were prove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a301ec53c5e5d30f9c2826f0541adfbf
https://doi.org/10.1074/jbc.m113.497990
https://doi.org/10.1074/jbc.m113.497990
Autor:
Martine Keenan, Eileen Ryan, Susan A. Charman, Jason H. Chaplin, Karen L. White, Eric Chatelain, Gong Chen, Jean-Robert Ioset, Zhisen Wang, Michael J. Abbott, Scott Cornwall, Wayne M. Best, Sarah Keatley, Paul W. Alexander, Thomas W. von Geldern, Hugo Diao, Catherine J. Perez, R.C. Andrew Thompson
Publikováno v:
Future Medicinal Chemistry. 5:1733-1752
Background: Inhibitors of Trypanosoma cruzi with novel mechanisms of action are urgently required to diversify the current clinical and preclinical pipelines. Increasing the number and diversity of hits available for assessment at the beginning of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de70cd8bb075d45ff1f1bb4e212c14b
https://doi.org/10.4155/fmc.13.139
https://doi.org/10.4155/fmc.13.139
[reaction: see text] Stereoselective aminohydroxylation and dihydroxylation using osmium(VIII) oxidants enabled the short and efficient synthesis of the aminocyclitol core of hygromycin A. In addition to allowing the selective introduction of the het
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c1d14ec946c0a0c848fb284e0b1dc4
https://ora.ox.ac.uk/objects/uuid:d49db24d-b926-42aa-919f-3d283ce200c7
https://ora.ox.ac.uk/objects/uuid:d49db24d-b926-42aa-919f-3d283ce200c7
Autor:
Tanya Armstrong, Thomas W. von Geldern, Sen Z. Wang, Bradley Berven, Michael J. Abbott, Ivan Scandale, Susan A. Charman, Jason H. Chaplin, Andrea Khong, Joshua D. McManus, Eric Chatelain, Adriana Botero, Wayne M. Best, Julia Morizzi, Maria Kerfoot, Tien Nguyen, Paul W. Alexander, Karen L. White, R.C. Andrew Thompson, Martine Keenan, Eileen Ryan
Publikováno v:
Journal of Medicinal Chemistry. 55:4189-4204
We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi ( T. cruzi ), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC(50)s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a30d423509261689188e5175fe646b
https://doi.org/10.1021/jm2015809
https://doi.org/10.1021/jm2015809
Publikováno v:
Current Opinion in Infectious Diseases. 24:586-592
PURPOSE OF REVIEW: Boron-based drugs represent a new class of molecules that have been found to exhibit attractive properties and activities against a number of protozoans causative of neglected tropical diseases. RECENT FINDINGS: This review highlig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47360186faf29807a74a9f8697fd5b8
https://doi.org/10.1097/qco.0b013e32834c630e
https://doi.org/10.1097/qco.0b013e32834c630e
Autor:
Martine, Keenan, Jason H, Chaplin
Publikováno v:
Progress in medicinal chemistry. 54
Recent clinical trials investigating treatment of chronic indeterminate Chagas disease with two re-purposed azole anti-fungal drugs, posaconazole and ravuconazole, revealed their inferiority to the current standard-of-care benznidazole and highlighte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e433e60f3394d9bb951a1327b1034d2c
https://pubmed.ncbi.nlm.nih.gov/25727705
https://pubmed.ncbi.nlm.nih.gov/25727705
Autor:
Martine Keenan, Jason H. Chaplin
Recent clinical trials investigating treatment of chronic indeterminate Chagas disease with two re-purposed azole anti-fungal drugs, posaconazole and ravuconazole, revealed their inferiority to the current standard-of-care benznidazole and highlighte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba96f5803f332a87f24111e1e5922e88
https://doi.org/10.1016/bs.pmch.2014.12.001
https://doi.org/10.1016/bs.pmch.2014.12.001