Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Martine J. Jager"'
Autor:
Arwin Groenewoud, Jie Yin, Maria Chiara Gelmi, Samar Alsafadi, Fariba Nemati, Didier Decaudin, Sergio Roman-Roman, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Martine J. Jager, Felix B. Engel, B. E. Snaar-Jagalska
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Uveal melanoma (UM) has a high risk to progress to metastatic disease with a median survival of 3.9 months after metastases detection, as metastatic UM responds poorly to conventional and targeted chemotherapy and is largely refractory to im
Externí odkaz:
https://doaj.org/article/35f875d9b6ee4910a5099e5b1b9ef6e8
Autor:
Maria Chiara Gelmi, MD, Annemijn P.A. Wierenga, MD, Wilma G.M. Kroes, MSc, Sjoerd G. van Duinen, MD, PhD, Jessica S. Karuntu, MD, Marina Marinkovic, MD, Jaco C. Bleeker, MD, Gregorius P.M. Luyten, MD, PhD, T.H. Khanh Vu, MD, PhD, Robert M. Verdijk, MD, PhD, Martine J. Jager, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 3, Pp 100297- (2023)
Purpose: Heavy pigmentation is known to be a prognostic risk factor in uveal melanoma (UM). We analyzed whether genetic tumor parameters were associated with tumor pigmentation and whether pigmentation should be included in prognostic tests. Design:
Externí odkaz:
https://doaj.org/article/07475fd972c34e2ca066b7680ff4d681
Autor:
Ruben V. Huis in ‘t Veld, Pablo Lara, Martine J. Jager, Roman I. Koning, Ferry Ossendorp, Luis J. Cruz
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Extracellular vesicles (EVs) are promising drug carriers of photosensitizers for photodynamic therapy (PDT) in cancer treatment, due to their ability to circulate in blood and enter cells efficiently. The therapeutic potential of EVs has bee
Externí odkaz:
https://doaj.org/article/d1583bc64cce4b1b8b12030c820a96bc
Autor:
Nikki Meijer, MD, Daniël P. de Bruyn, MD, Annelies de Klein, PhD, Dion Paridaens, MD, PhD, Robert M. Verdijk, MD, PhD, Tos T.J. M. Berendschot, PhD, Erwin Brosens, PhD, Martine J. Jager, MD, PhD, Emine Kiliç, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 2, Iss 2, Pp 100117- (2022)
Purpose: To determine whether peripheral blood leukocyte numbers and serum markers of inflammation can be used to predict which patients with primary uveal melanoma will develop metastasis. Design: Retrospective study. Participants: Medical records o
Externí odkaz:
https://doaj.org/article/50c3199c4886494e96055e1ada6e5f2d
Autor:
Gülçin Gezgin, MD, Marten Visser, MSc, Dina Ruano, PhD, Saskia J. Santegoets, PhD, Noel F.C.C. de Miranda, PhD, Pieter A. van der Velden, PhD, Gregorius P.M. Luyten, MD, PhD, Sjoerd H. van der Burg, PhD, Els M. Verdegaal, PhD, Martine J. Jager, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 2, Iss 2, Pp 100132- (2022)
Purpose: To evaluate whether expanded tumor-infiltrating lymphocytes (TILs) can be obtained from primary uveal melanoma (UM) for potential use as adjuvant treatment in patients at risk of developing metastatic disease. Design: Experimental research s
Externí odkaz:
https://doaj.org/article/3c89ed8a810341619ae83b4be7532151
Autor:
Maria Chiara Gelmi, Robert M. Verdijk, Laurien E. Houtzagers, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, T. H. Khanh Vu, Martine J. Jager
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8861 (2023)
Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. In cutaneous melanoma, MITF loss has been linked to an increased expression of stem cell markers, a shift in epithelial-to-me
Externí odkaz:
https://doaj.org/article/b52e2f79602a4f998f31a02a691b8a6b
Autor:
Jie Yin, Gangyin Zhao, Helen Kalirai, Sarah E. Coupland, Aart G. Jochemsen, Gabriel Forn-Cuní, Annemijn P. A. Wierenga, Martine J. Jager, B. Ewa Snaar-Jagalska, Arwin Groenewoud
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 598 (2023)
Uveal melanoma (UM) is a rare malignant cancer of the eye, with up to 50% of patients dying from metastasis, for which no effective treatment is available. Due to the rarity of the disease, there is a great need to harness the limited material availa
Externí odkaz:
https://doaj.org/article/926cbf25627a4e6385fb3c70e89d75a4
Autor:
Rogier J. Nell, Nino V. Menger, Mieke Versluis, Gregorius P. M. Luyten, Robert M. Verdijk, Michele C. Madigan, Martine J. Jager, Pieter A. van der Velden
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Activating Gαq signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT2R) forms a rare
Externí odkaz:
https://doaj.org/article/b4370d2a344542988969c853605cedea
Autor:
Ruben V. Huis in ‘t Veld, Jeroen Heuts, Sen Ma, Luis J. Cruz, Ferry A. Ossendorp, Martine J. Jager
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 330 (2023)
BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are generated that ultimately induce cell death and disruption of the tumor area. Moreover,
Externí odkaz:
https://doaj.org/article/66d395d081cb4d039e09cc9742bdb708
Autor:
Alexander C. Leeksma, Ingrid A. M. Derks, M. Haidar Kasem, Emine Kilic, Annelies de Klein, Martine J. Jager, Arjan A. van de Loosdrecht, Joop H. Jansen, Veronika Navrkalova, Laura M. Faber, Nadja Zaborsky, Alexander Egle, Thorsten Zenz, Sarka Pospisilova, Omar Abdel-Wahab, Arnon P. Kater, Eric Eldering
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Recurrent mutations in splicing factor 3B subunit 1 (SF3B1) have been identified in several malignancies and are associated with an increased expression of 3’ cryptic transcripts as a result of alternative branchpoint recognition. A large fraction
Externí odkaz:
https://doaj.org/article/91502537fb6b4b8b844b64388f53fc8a